Molecular Mechanisms of Myogenic Coactivation by p300: Direct Interaction with the Activation Domain of MyoD and with the MADS Box of MEF2C

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

Current protocols in molecular biology

1988 • 4,543 citations

A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins

1989 • 2,706 citations

A CBP Integrator Complex Mediates Transcriptional Activation and AP-1 Inhibition by Nuclear Receptors

1996 • 2,183 citations

Phosphorylated CREB binds specifically to the nuclear protein CBP

1993 • 2,039 citations

Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence

1989 • 1,876 citations

MyoD or Myf-5 is required for the formation of skeletal muscle

1993 • 1,663 citations

Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2

1993 • 1,531 citations

Nuclear protein CBP is a coactivator for the transcription factor CREB

1994 • 1,447 citations

Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene

1993 • 1,314 citations

Correlation of Terminal Cell Cycle Arrest of Skeletal Muscle with Induction of p21 by MyoD

1995 • 1,154 citations

The MyoD family and myogenesis: Redundancy, networks, and thresholds

1993 • 1,062 citations

p53-Independent Expression of p21 ^Cip1 in Muscle and Other Terminally Differentiating Cells

1995 • 1,058 citations

Inactivation of MyoD in mice leads to up-regulation of the myogenic HLH gene Myf-5 and results in apparently normal muscle development

1992 • 973 citations

Differences and Similarities in DNA-Binding Preferences of MyoD and E2A Protein Complexes Revealed by Binding Site Selection

1990 • 957 citations

Myogenin gene disruption results in perinatal lethality because of severe muscle defect

1993 • 912 citations

Functional activity of myogenic HLH proteins requires hetero-oligomerization with E12/E47-like proteins in vivo

1991 • 874 citations

A gene with homology to the myc similarity region of MyoD1 is expressed during myogenesis and is sufficient to activate the muscle differentiation program.

1989 • 863 citations

Cooperative activation of muscle gene expression by MEF2 and myogenic bHLH proteins

1995 • 817 citations

The MyoD DNA binding domain contains a recognition code for muscle-specific gene activation

1990 • 794 citations

Identification of MRF4: a new member of the muscle regulatory factor gene family.

1989 • 779 citations

MyoD family: a paradigm for development?

1990 • 776 citations

Targeted inactivation of the muscle regulatory gene Myf-5 results in abnormal rib development and perinatal death

1992 • 700 citations

A new myocyte-specific enhancer-binding factor that recognizes a conserved element associated with multiple muscle-specific genes.

1989 • 605 citations

Adenoviral ElA-associated protein p300 as a functional homologue of the transcriptional co-activator CBP

1995 • 578 citations

A family of transcriptional adaptor proteins targeted by the E1A oncoprotein

1995 • 534 citations

Induction of differentiation in human promyelocytic HL-60 leukemia cells activates p21, WAF1/CIP1, expression in the absence of p53.

1994 • 514 citations

Induction of p21 (WAF-1/CIP1) during differentiation.

1994 • 493 citations

Human myocyte-specific enhancer factor 2 comprises a group of tissue-restricted MADS box transcription factors.

1992 • 491 citations

Herculin, a fourth member of the MyoD family of myogenic regulatory genes.

1990 • 482 citations

Critical Structural Elements of the VP16 Transcriptional Activation Domain

1991 • 461 citations

COMMON THEMES IN ASSEMBLY AND FUNCTION OF EUKARYOTIC TRANSCRIPTION COMPLEXES

1995 • 434 citations

The regulation of myogenin gene expression during the embryonic development of the mouse.

1993 • 419 citations

MyoD-Induced Expression of p21 Inhibits Cyclin-Dependent Kinase Activity upon Myocyte Terminal Differentiation

1995 • 416 citations

Inhibition of myogenic differentiation in proliferating myoblasts by cyclin D1-dependent kinase

1995 • 404 citations

Association of adenovirus early-region 1A proteins with cellular polypeptides.

1986 • 368 citations

Regulation of Muscle Differentiation by the MEF2 Family of MADS Box Transcription Factors

1995 • 348 citations

CBP as a transcriptional coactivator of c-Myb.

1996 • 347 citations

Muscle-specific transcriptional activation by MyoD.

1991 • 347 citations

CBP-induced stimulation of c-Fos activity is abrogated by E1A.

1995 • 342 citations

Involvement of the cell-cycle inhibitor Cip1/WAF1 and the E1A-associated p300 protein in terminal differentiation.

1995 • 338 citations

Muscle-specific expression of the cardiac alpha-actin gene requires MyoD1, CArG-box binding factor, and Sp1.

1990 • 334 citations

Human p300 Protein Is a Coactivator for the Transcription Factor MyoD

1996 • 319 citations

Inactivation of the myogenic bHLH gene MRF4 results in up-regulation of myogenin and rib anomalies.

1995 • 308 citations

Relief of YY1 transcriptional repression by adenovirus E1A is mediated by E1A-associated protein p300.

1995 • 305 citations

Analysis of the myogenin promoter reveals an indirect pathway for positive autoregulation mediated by the muscle-specific enhancer factor MEF-2.

1992 • 302 citations

MyoD binds cooperatively to two sites in a target enhancer sequence: occupancy of two sites is required for activation.

1990 • 294 citations

Myocyte enhancer factor (MEF) 2C: a tissue-restricted member of the MEF-2 family of transcription factors.

1993 • 267 citations

Myogenin induces the myocyte-specific enhancer binding factor MEF-2 independently of other muscle-specific gene products.

1991 • 264 citations

Pattern of aromatic and hydrophobic amino acids critical for one of two subdomains of the VP16 transcriptional activator.

1993 • 261 citations

Separable Regulatory Elements Governing myogenin Transcription in Mouse Embryogenesis

1993 • 258 citations

Association of p300 and CBP with Simian Virus 40 Large T Antigen

1996 • 246 citations

DNA tumor virus transforming proteins and the cell cycle

1993 • 242 citations

Activation of the Myogenic Lineage by MEF2A, a Factor that Induces and Cooperates with MyoD

1994 • 223 citations

Disruption of the mouse MRF4 gene identifies multiple waves of myogenesis in the myotome

1995 • 220 citations

Adenovirus E1A products suppress myogenic differentiation and inhibit transcription from muscle-specific promoters

1988 • 183 citations

Largest subunit of Drosophila transcription factor IID directs assembly of a complex containing TBP and a coactivator

1993 • 176 citations

Inactivation of Myf-6 and Myf-5 genes in mice leads to alterations in skeletal muscle development.

1995 • 172 citations

Mutagenesis of the myogenin basic region identifies an ancient protein motif critical for activation of myogenesis.

1991 • 159 citations

HLH forced dimers: Tethering MyoD to E47 generates a dominant positive myogenic factor insulated from negative regulation by Id

1993 • 157 citations

Adenovirus E1A Downregulates cJun- and JunB-Mediated Transcription by Targeting Their Coactivator p300

1996 • 156 citations

Wiring diagrams: regulatory circuits and the control of skeletal myogenesis

1994 • 154 citations

The SV40 large T antigen and adenovirus E1a oncoproteins interact with distinct isoforms of the transcriptional co-activator, p300.

1996 • 147 citations

Acquisition of myogenic specificity by replacement of three amino acid residues from MyoD into E12

1992 • 147 citations

Transcriptional coactivators in yeast and beyond

1995 • 146 citations

p300, and p300-associated proteins, are components of TATA-binding protein (TBP) complexes.

1993 • 120 citations

The basic region of myogenin cooperates with two transcription activation domains to induce muscle-specific transcription.

1992 • 110 citations

Skeletal myogenesis: genetics and embryology to the fore

1993 • 103 citations

Tissue-specific gene activation by MyoD: determination of specificity by cis-acting repression elements.

1994 • 100 citations

Functional interactions within adenovirus E1A protein complexes.

1994 • 100 citations

Phosphorylation of the adenovirus E1A-associated 300 kDa protein in response to retinoic acid and E1A during the differentiation of F9 cells.

1995 • 94 citations

Regulation of MyoD gene transcription and protein function by the transforming domains of the adenovirus E1A oncoprotein.

1993 • 83 citations

Inefficient homooligomerization contributes to the dependence of myogenin on E2A products for efficient DNA binding.

1991 • 81 citations

Inhibition of muscle differentiation by the adenovirus E1a protein: repression of the transcriptional activating function of the HLH protein Myf-5.

1992 • 79 citations

Muscle: the regulation of myogenesis

1994 • 78 citations

Muscle basic helix-loop-helix proteins and the regulation of myogenesis

1992 • 69 citations

Binding of TFIID and MEF2 to the TATA element activates transcription of the Xenopus MyoDa promoter.

1994 • 66 citations

E1A-mediated inhibition of myogenesis correlates with a direct physical interaction of E1A12S and basic helix-loop-helix proteins.

1993 • 56 citations

Expression of myogenic factors in denervated chicken breast muscle: isolation of the chicken Myf5 gene

1993 • 53 citations

The Adenovirus E1A-associated 300-kD Protein Exhibits Properties of a Transcriptional Coactivator and Belongs to an Evolutionarily Conserved Family

1994 • 46 citations

Transcription revisited: a commentary on the 1995 Cold Spring Harbor Laboratory meeting, "Mechanisms of Eukaryotic Transcription".

1996 • 46 citations

The MRF4 activation domain is required to induce muscle-specific gene expression.

1992 • 44 citations

Different E-box regulatory sequences are functionally distinct when placed within the context of the troponin I enhancer

1992 • 43 citations

Differences between MyoD DNA Binding and Activation Site Requirements Revealed by Functional Random Sequence Selection

1996 • 42 citations

Positive control mutations in the MyoD basic region fail to show cooperative DNA binding and transcriptional activation in vitro.

1994 • 41 citations

The adenovirus E1A 289R and 243R proteins inhibit the phosphorylation of p300.

1994 • 40 citations