The role of proteolytic enzymes in cancer invasion and metastasis

Metastatic potential correlates with enzymatic degradation of basement membrane collagen

1980 • 1,778 citations

Proteases and biological control

1976 • 1,380 citations

Critical factors in the biology of human cancer metastasis: twenty-eighth G.H.A. Clowes memorial award lecture.

1990 • 1,147 citations

A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas

1990 • 1,140 citations

SV40-transformed Human Lung Fibroblasts Secrete a 92-kDa Type IV Collagenase Which Is Identical to That Secreted by Normal Human Macrophages

1989 • 1,122 citations

Structure and biological activity of basement membrane proteins

1989 • 967 citations

Proteolytic activation of latent transforming growth factor-beta from fibroblast-conditioned medium.

1988 • 962 citations

Journal of the National Cancer Institute

1993 • 945 citations

Journal of the National Cancer Institute

1958 • 779 citations

Tumor invasion through the human amniotic membrane: Requirement for a proteinase cascade

1986 • 764 citations

A cellular binding site for the Mr 55,000 form of the human plasminogen activator, urokinase.

1985 • 731 citations

Antibodies to plasminogen activator inhibit human tumor metastasis

1983 • 651 citations

Proteolytic degradation of extracellular matrix in tumor invasion

1987 • 484 citations

A secreted glycoprotein induced by estrogen in human breast cancer cell lines

1980 • 481 citations

Cathepsin D and Prognosis in Breast Cancer

1990 • 473 citations

Antisense RNA-Induced Reduction in Murine TIMP Levels Confers Oncogenicity on Swiss 3T3 Cells

1989 • 459 citations

Differentiation-enhanced binding of the amino-terminal fragment of human urokinase plasminogen activator to a specific receptor on U937 monocytes.

1985 • 450 citations

Plasminogen activation and regulation of pericellular proteolysis

1985 • 439 citations

Further studies on the activation of procollagenase, the latent precursor of bone collagenase. Effects of lysosomal cathepsin B, plasmin and kallikrein, and spontaneous activation

1977 • 389 citations

Lysosomal Cathepsin B: Correlation with Metastatic Potential

1981 • 370 citations

Cathepsin B efficiently activates the soluble and the tumor cell receptor-bound form of the proenzyme urokinase-type plasminogen activator (Pro-uPA).

1991 • 347 citations

CATHEPSIN D: AN INDEPENDENT PROGNOSTIC FACTOR FOR METASTASIS OF BREAST CANCER

1989 • 327 citations

Inhibition by human recombinant tissue inhibitor of metalloproteinases of human amnion invasion and lung colonization by murine B16-F10 melanoma cells.

1988 • 312 citations

Heparanases and tumor metastasis

1988 • 303 citations

Urokinase-plasminogen activator, a marker for aggressive breast carcinomas. Preliminary report

1988 • 294 citations

Urokinase-plasminogen activator, a new and independent prognostic marker in breast cancer.

1990 • 294 citations

Autocrine Growth Stimulation of the MCF 7 Breast Cancer Cells by the Estrogen-Regulated 52 K Protein*

1986 • 273 citations

In vivo invasion of modified chorioallantoic membrane by tumor cells: the role of cell surface-bound urokinase.

1988 • 273 citations

Increased capillary endothelial cell protease activity in response to angiogenic stimuli in vitro.

1983 • 261 citations

Association between high concentrations of Mr 52,000 cathepsin D and poor prognosis in primary human breast cancer.

1989 • 250 citations

In vitro degradation of extracellular matrix with Mr 52,000 cathepsin D secreted by breast cancer cells.

1988 • 242 citations

Partial purification and characterization of a neutral protease which cleaves type IV collagen

1981 • 241 citations

Clinical Relevance of the Urokinase-Type and Tissue-Type Plasminogen Activators and of Their Type 1 Inhibitor in Breast Cancer

1991 • 236 citations

Inhibition of Collagenolytic Activity and Metastasis of Tumor Cells by a Recombinant Human Tissue Inhibitor of Metalloproteinases

1990 • 233 citations

Thrombin stimulates tumor-platelet adhesion in vitro and metastasis in vivo.

1991 • 231 citations

Increased secretion, altered processing, and glycosylation of pro-cathepsin D in human mammary cancer cells.

1989 • 228 citations

Secretion of type IV collagenolytic protease and metastatic phenotype: induction by transfection with c-Ha-ras but not c-Ha-ras plus Ad2-E1a.

1987 • 226 citations

Modulation of metastatic potential by cell surface urokinase of murine melanoma cells.

1988 • 223 citations

Cathepsin B: association with plasma membrane in metastatic tumors.

1986 • 222 citations

Expression of collagenase‐related metalloproteinase genes in human lung or head and neck tumours

1991 • 210 citations

Mr 92,000 gelatinase release correlates with the metastatic phenotype in transformed rat embryo cells.

1990 • 202 citations

Urokinase-type plasminogen activator (u-PA) antigen is a predictor of early relapse in breast cancer

1990 • 189 citations

Cathepsin B and its endogenous inhibitors: the role in tumor malignancy

1990 • 187 citations

Overexpression of transfected cathepsin D in transformed cells increases their malignant phenotype and metastatic potency.

1990 • 181 citations

Inhibition of urokinase-type plasminogen activator by antibodies: the effect on dissemination of a human tumor in the nude mouse.

1991 • 179 citations

Immunocytochemical localization of urokinase-type plasminogen activator in Lewis lung carcinoma.

1984 • 173 citations

Identification of latent procathepsins B and L in microsomal lumen: Characterization of enzymatic activation and proteolytic processing in vitro

1988 • 161 citations

The role of urokinase-type plasminogen activator in aggressive tumor cell behavior

1990 • 158 citations

Matrix metalloproteinases and tissue inhibitor of metalloproteinases: a review of their role in tumorigenesis and tissue invasion.

1989 • 158 citations

Prognostic significance of the estrogen-regulated protein, cathepsin D, in breast cancer. An immunohistochemical study

1990 • 150 citations

Cathepsin D: A protease involved in breast cancer metastasis

1990 • 140 citations

Correlation of the production of plasminogen activator with tumor metastasis in B16 mouse melanoma cell lines.

1980 • 138 citations

Inhibition of tumor invasion of smooth muscle cell layers by recombinant human metalloproteinase inhibitor.

1991 • 135 citations

Proliferation of a human epidermal tumor cell line stimulated by urokinase

1987 • 132 citations

Plasminogen-activator inhibitor type 1 is a potent natural inhibitor of extracellular matrix degradation by fibrosarcoma and colon carcinoma cells.

1990 • 131 citations

Expression of Human Recombinant Plasminogen Activators Enhances Invasion and Experimental Metastasis of H-ras-Transformed NIH 3T3 Cells

1989 • 120 citations

Expression of five cathepsins in murine melanomas of varying metastatic potential and normal tissues.

1989 • 119 citations

Inhibition of cancer cell urokinase plasminogen activator by its specific inhibitor PAI-2 and subsequent effects on extracellular matrix degradation.

1990 • 112 citations

Stromelysin in tumor progression and metastasis

1990 • 105 citations

Human Ovarian Tumor-associated Trypsin

1989 • 105 citations

Localization <italic>In Vivo</italic> of Radioiodinated Anti-Rat-Fibrin Antibodies and Radioiodinated Rat Fibrinogen in the Murphy Rat Lymphosarcoma and in Other Transplantable Rat Tumors<xref ref-type="fn" rid="FN1">2</xref>

1959 • 103 citations

Mouse L cells expressing human prourokinase-type plasminogen activator: effects on extracellular matrix degradation and invasion.

1989 • 99 citations

Relationship between secreted urokinase plasminogen activator activity and metastatic potential in murine B16 cells transfected with human urokinase sense and antisense genes.

1990 • 99 citations

Immunohistochemical evidence of urokinase-type plasminogen activator in primary and metastatic tumors of pulmonary adenocarcinoma.

1991 • 96 citations

Differential protease expression by cutaneous squamous and basal cell carcinomas.

1991 • 95 citations

Expression of human recombinant plasminogen activators enhances invasion and experimental metastasis of H-ras-transformed NIH 3T3 cells.

1989 • 95 citations

Effect of proteinase inhibitors on intracellular processing of cathepsin B, H and L in rat macrophages

1988 • 94 citations

Human urokinase-type plasminogen activator stimulates chemotaxis of human neutrophils

1987 • 92 citations

Laminin receptors, collagenase IV and prognosis in node‐negative breast cancers

1991 • 91 citations

Tissue-type plasminogen activator, a new prognostic marker in breast cancer.

1988 • 88 citations

Tumor Cell-Platelet Aggregation: Induced by Cathepsin B-Like Proteinase and Inhibited by Prostacyclin

1982 • 83 citations

Modulation of type‐iv collagenase activity and invasive behavior of metastatic human melanoma (A2058) cells in vitro by monoclonal antibodies to type‐iv collagenase

1990 • 76 citations

Production of collagenase and inhibitor (TIMP) by intracranial tumors and dura in vitro

1983 • 75 citations

Plasminogen activator inhibitor-type 1 in Lewis lung carcinoma

1990 • 74 citations

A fibrosarcoma model derived from mouse embryo cells: Growth properties and secretion of collagenase and metalloproteinase inhibitor (TIMP) by tumour cell lines

1984 • 74 citations

Plasminogen activators and cancer.

1990 • 73 citations

Collagenase Activity in Epidermoid Carcinoma of the Oral Cavity and Larynx

1975 • 71 citations

Involvement of plasminogen activator production with tumor metastasis in a rat model.

1984 • 66 citations

Do proteases play a role in cancer invasion and metastasis?

1987 • 65 citations

Correlation of collagenase secretion with metastatic-colonization potential in naturally occurring murine mammary tumours

1982 • 59 citations

Inhibitory properties of low molecular mass cysteine proteinase inhibitors from human sarcoma

1989 • 55 citations

Cathepsin B to cysteine proteinase inhibitor balance in metastatic cell subpopulations isolated from murine tumors.

1990 • 47 citations

Relationship between cellular procoagulant activity and metastatic capacity of B16 mouse melanoma variants.

1983 • 45 citations

Biochemical methods for predicting metastatic ability of prostatic cancer utilizing the dunning R-3327 rat prostatic adenocarcinoma system as a model.

1984 • 44 citations

Cathepsin B-Like Proteinase as a Marker for Metastatic Tumor Cell Variants

1984 • 42 citations

Extracellular cysteine proteinase and collagenase activities as a consequence of tumor-host interaction in the rabbit V2 carcinoma.

1984 • 40 citations

Invasion and metastasis

1990 • 39 citations

Cellular detachment by purified lysosomal cathepsin B

1968 • 37 citations

Proteolytic Enzymes in Tumor Metastasis. I. Plasminogen Activator in Clones of Lewis Lung Carcinoma and T10 Sarcoma&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;

1985 • 32 citations

Clinical and experimental studies on the biology of metastasis

1985 • 32 citations

Identification of latent procathepsin H in microsomal lumen: Characterization of proteolytic processing and enzyme activation

1988 • 30 citations

Tissue-Type Plasminogen Activator in Breast Cancer: Relationship With Estradiol and Progesterone Receptors

1986 • 30 citations

The glycosylation state of the precursors of the cathepsin B-like proteinase from human malignant ascitic fluid: Possible implication in the secretory pathway of these proenzymes

1989 • 30 citations

Identification of cell surface cathepsin B-like activity on murine melanomas and fibrosarcomas: modulation by butanol extraction.

1988 • 24 citations

Role for different cell proteinases in cancer invasion and cytolysis

1985 • 22 citations

Effects of tranexamic acid and urokinase on hematogenous metastases of Lewis lung carcinoma in mice.

1981 • 19 citations

Biochimica et biophysica acta

1974 • 18 citations

Invasion potential of human choriocarcinoma cell lines and the role of lytic enzymes

1985 • 17 citations

Biochimica et Biophysica Acta

1984 • 17 citations

Effect of urokinase on growth and metastases of rabbit V2 carcinoma.

1978 • 13 citations

Differential release of active proteinase inhibitors by two rat mammary adenocarcinoma variants possessing different metastatic potentials.

1991 • 7 citations

A novel TIMP‐insensitive type IV collagen‐degrading metalloproteinase from murine metastatic sarcoma cells

1990 • 6 citations

Urokinase-type plasminogen activator and its inhibitor PAI-1 in human breast cancer

1989 • 1 citations