Crohn's disease

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

2001 • 5,526 citations

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

2001 • 4,997 citations

Tuberculosis Associated with Infliximab, a Tumor Necrosis Factor α–Neutralizing Agent

2001 • 3,631 citations

A Short-Term Study of Chimeric Monoclonal Antibody cA2 to Tumor Necrosis Factor α for Crohn's Disease

1997 • 3,152 citations

Infliximab for the Treatment of Fistulas in Patients with Crohn's Disease

1999 • 2,656 citations

Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria

2001 • 2,472 citations

Cytotoxic T Lymphocyte–Associated Antigen 4 Plays an Essential Role in the Function of Cd25+Cd4+ Regulatory Cells That Control Intestinal Inflammation

2000 • 2,211 citations

Treatment of Murine Colitis by Lactococcus lactis Secreting Interleukin-10

2000 • 1,406 citations

Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: Evidence in Crohn disease and experimental colitis in vivo

2000 • 1,255 citations

Differential Alteration in Intestinal Epithelial Cell Expression of Toll-Like Receptor 3 (TLR3) and TLR4 in Inflammatory Bowel Disease

2000 • 1,246 citations

Anti-TNFα Therapy of Rheumatoid Arthritis: What Have We Learned?

2001 • 1,237 citations

The indigenous gastrointestinal microflora

1996 • 1,149 citations

Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations

2001 • 1,096 citations

Pharmacogenomics and metabolite measurement for 6-mercaptopurine therapy in inflammatory bowel disease

2000 • 998 citations

Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease (IBD)

1995 • 965 citations

Early lesions of recurrent Crohn's disease caused by infusion of intestinal contents in excluded ileum

1998 • 854 citations

Prokaryotic Regulation of Epithelial Responses by Inhibition of IκB-α Ubiquitination

2000 • 837 citations

Presence of adherent Escherichia coli strains in ileal mucosa of patients with Crohn's disease

1998 • 832 citations

Lipopolysaccharide Activates Distinct Signaling Pathways in Intestinal Epithelial Cell Lines Expressing Toll-Like Receptors

2000 • 754 citations

Freshly Isolated Peyer's Patch, but Not Spleen, Dendritic Cells Produce Interleukin 10 and Induce the Differentiation of T Helper Type 2 Cells

1999 • 656 citations

Epithelial cells as sensors for microbial infection.

1997 • 623 citations

CTLA4Ig-mediated blockade of T-cell costimulation in patients with psoriasis vulgaris

1999 • 607 citations

Animal models of mucosal inflammation and their relation to human inflammatory bowel disease

1999 • 456 citations

Give us this day our daily germs

1998 • 399 citations

CD4+ T Cells Reactive to Enteric Bacterial Antigens in Spontaneously Colitic C3H/HeJBir Mice: Increased T Helper Cell Type 1 Response and Ability to Transfer Disease

1998 • 393 citations

Inflammatory bowel disease: Immunodiagnostics, immunotherapeutics, and ecotherapeutics

2001 • 373 citations

T cells in inflammatory bowel disease: protective and pathogenic roles

1995 • 359 citations

Inflammatory bowel disease and domestic hygiene in infancy

1994 • 358 citations

Resistance of Crohn’s Disease T Cells to Multiple Apoptotic Signals Is Associated with a Bcl-2/Bax Mucosal Imbalance

1999 • 347 citations

A major role for matrix metalloproteinases in T cell injury in the gut.

1997 • 329 citations

High multidrug resistance (P-glycoprotein 170) expression in inflammatory bowel disease patients who fail medical therapy

2000 • 289 citations

Lamina propria T cells in Crohn's disease and other gastrointestinal inflammation show defective CD2 pathway-induced apoptosis

1999 • 269 citations

Does the failure to acquire helminthic parasites predispose to Crohn's disease?

2000 • 266 citations

The role of CD4+ lymphocytes in the susceptibility of mice to stress-induced reactivation of experimental colitis

1999 • 255 citations

Therapy of inflammatory bowel disease

2000 • 248 citations

Th1-type responses mediate spontaneous ileitis in a novel murine model of Crohn’s disease

2001 • 247 citations

ANCA pattern and LTA haplotype relationship to clinical responses to anti-TNF antibody treatment in Crohn's disease

2001 • 224 citations

Probiotics and Inflammatory Bowel Disease: Is There a Scientific Rationale?

2000 • 204 citations

Role of the faecal stream in the maintenance of Crohn's colitis.

1985 • 203 citations

Animal models of intestinal inflammation: new insights into the molecular pathogenesis and immunotherapy of inflammatory bowel disease

2000 • 154 citations

Imbalance of stromelysin-1 and TIMP-1 in the mucosal lesions of children with inflammatory bowel disease

2000 • 152 citations

The Neglected Organ: Bacterial Flora Has a Crucial Immunostimulatory Role

1992 • 149 citations

Characterisation of inorganic microparticles in pigment cells of human gut associated lymphoid tissue.

1996 • 144 citations

Epithelial cell growth and differentiation. III. Promoting diversity in the intestine: conversations between the microflora, epithelium, and diffuse GALT

1997 • 121 citations

Enteric microflora in IBD: Pathogens or commensals?

1997 • 110 citations

The resident faecal flora is determined by genetic characteristics of the host. Implications for Crohn's disease?

1983 • 108 citations

Suppression of T cell–mediated injury in human gut by interleukin 10: Role of matrix metalloproteinases

1998 • 87 citations

IL-12 and Th1 immune responses in human Peyer's patches

2001 • 81 citations

Absence of Escherichia coli, Listeria monocytogenes, and Klebsiella pneumoniae antigens within inflammatory bowel disease tissues

1998 • 66 citations

Commensal bacteria as targets in Crohn's disease

2000 • 58 citations

V. Mechanisms of immunologic sensation of intestinal contents

2000 • 56 citations

Brain-gut axis and mucosal immunity: a perspective on mucosal psychoneuroimmunology.

1999 • 56 citations

Measles Virus and Crohn's Disease: A Critical Appraisal of the Current Literature

2001 • 48 citations

Enteric Microflora in IBD: Pathogens or Commensals?

1997 • 35 citations

Genetics of inflammatory bowel disease

2007 • 31 citations

Patients' awareness of adverse relation between Crohn's disease and their smoking: questionnaire survey

1996 • 30 citations

Genetics of Inflammatory Bowel Disease: A Reappraisal

2000 • 27 citations

Odd forms of inflammatory bowel disease: What can they tell us?

1993 • 16 citations

The genetic background of inflammatory bowel disease.

2000 • 15 citations