Lamina propria T cells in Crohn's disease and other gastrointestinal inflammation show defective CD2 pathway-induced apoptosis

Two CD95 (APO-1/Fas) signaling pathways

1998 • 3,045 citations

Inhibition of death receptor signals by cellular FLIP

1997 • 2,577 citations

Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas

1995 • 1,346 citations

Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors

1997 • 1,305 citations

Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5.

1996 • 1,227 citations

lnterleukin-2 programs mouse αβ T lymphocytes for apoptosis

1991 • 1,027 citations

Immunobiology and immunopathology of human gut mucosa: Humoral immunity and intraepithelial lymphocytes

1989 • 552 citations

Tumour necrosis factor-alpha and interferon-gamma production measured at the single cell level in normal and inflamed human intestine

1990 • 489 citations

Isolation and functional characterization of human intestinal mucosal lymphoid cells.

1977 • 403 citations

Cytokine-induced survival of activated T cellsin vitroandin vivo

1998 • 395 citations

Interleukin‐2 receptor common γ‐chain signaling cytokines regulate activated T cell apoptosis in response to growth factor withdrawal: Selective induction of anti‐apoptotic (bcl‐2, bcl‐x_L) but not pro‐apoptotic (bax, bcl‐x_S) gene expression

1996 • 367 citations

Interleukin-2- and interferon-gamma-secreting T cells in normal and diseased human intestinal mucosa.

1993 • 324 citations

Fas-induced Activation of the Cell Death-related Protease CPP32 Is Inhibited by Bcl-2 and by ICE Family Protease Inhibitors

1996 • 321 citations

Activation-induced cell death (apoptosis) of mature peripheral T lymphocytes

1993 • 314 citations

Cellular environments and apoptosis: tissue microenvironments control activated T-cell death

1997 • 226 citations

RETRACTED: The Fas/Fas Ligand Pathway and Bcl-2 Regulate T Cell Responses to Model Self and Foreign Antigens

1998 • 216 citations

Cytokine Response Modifier A (CrmA) Inhibits Ceramide Formation in Response to Tumor Necrosis Factor (TNF)-α: CrmA and Bcl-2 Target Distinct Components in the Apoptotic Pathway

1997 • 210 citations

The progressive differentiation of primed T cells is associated with an increasing susceptibility to apoptosis

1994 • 210 citations

Increased activation of isolated intestinal lamina propria mononuclear cells in inflammatory bowel disease

1991 • 207 citations

Definition of a lamina propria T cell responsive state. Enhanced cytokine responsiveness of T cells stimulated through the CD2 pathway.

1995 • 182 citations

Spontaneous release of interferon gamma by intestinal lamina propria lymphocytes in Crohn's disease. Kinetics of in vitro response to interferon gamma inducers.

1991 • 171 citations

Stimulated human lamina propria T cells manifest enhanced Fas-mediated apoptosis.

1996 • 141 citations

Optimal detection of apoptosis by flow cytometry depends on cell morphology

1993 • 127 citations

Functional Roles of Fas and Bcl-2-Regulated Apoptosis of T Lymphocytes

1998 • 126 citations

Functional expression of Fas and Fas ligand on human gut lamina propria T lymphocytes. A potential role for the acidic sphingomyelinase pathway in normal immunoregulation.

1996 • 124 citations

Activation and signaling status of human lamina propria T lymphocytes

1991 • 102 citations

Differential responsiveness to CD3‐Ti vs. CD2‐dependent activation of human intestinal T lymphocytes

1990 • 97 citations

Apoptosis signaling pathways in normal T cells: differential activity of Bcl-2 and IL-1beta-converting enzyme family protease inhibitors on glucocorticoid- and Fas-mediated cytotoxicity.

1996 • 53 citations

Hypoproliferative human lamina propria T cells retain the capacity to secrete lymphokines when stimulated via CD2/CD28 pathways.

1996 • 37 citations

Crohn's disease (CD) mucosal T-cells are resistant to apoptosis

1995 • 8 citations