Th1-type responses mediate spontaneous ileitis in a novel murine model of Crohn’s disease

Interleukin-10-deficient mice develop chronic enterocolitis

1993 • 4,225 citations

Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene

1993 • 1,762 citations

Antibodies to interleukin 12 abrogate established experimental colitis in mice.

1995 • 1,338 citations

Impaired On/Off Regulation of TNF Biosynthesis in Mice Lacking TNF AU-Rich Elements

1999 • 1,325 citations

Inflammatory Bowel Disease

1991 • 1,264 citations

Experimental models of inflammatory bowel disease

1995 • 1,215 citations

Inhibition of Thl responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells

1994 • 1,129 citations

Efficacy and safety of retreatment with anti–tumor necrosis factor antibody (infliximab) to maintain remission in Crohn's disease

1999 • 1,107 citations

Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment

1995 • 1,079 citations

Phenotypically distinct subsets of CD4⁺ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice

1993 • 1,064 citations

A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells.

1996 • 909 citations

Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice

1993 • 732 citations

Regulatory interactions between CD45RBhigh and CD45RBlow CD4+ T cells are important for the balance between protective and pathogenic cell-mediated immunity.

1994 • 630 citations

Animal models of mucosal inflammation and their relation to human inflammatory bowel disease

1999 • 456 citations

Experimental granulomatous colitis in mice is abrogated by induction of TGF-beta-mediated oral tolerance.

1996 • 444 citations

Ulcerative colitis and adenocarcinoma of the colon in Gαi2-deficient mice

1995 • 416 citations

T helper cell 1-type CD4+ T cells, but not B cells, mediate colitis in interleukin 10-deficient mice.

1996 • 399 citations

CD4+ T Cells Reactive to Enteric Bacterial Antigens in Spontaneously Colitic C3H/HeJBir Mice: Increased T Helper Cell Type 1 Response and Ability to Transfer Disease

1998 • 393 citations

Contribution of genes of the major histocompatibility complex to susceptibility and disease phenotype in inflammatory bowel disease

1996 • 371 citations

T cells in inflammatory bowel disease: protective and pathogenic roles

1995 • 359 citations

Tolerance towards resident intestinal flora in mice is abrogated in experimental colitis and restored by treatment with interleukin‐10 or antibodies to interleukin‐12

1996 • 358 citations

Blocking the CD40L-CD40 interaction in vivo specifically prevents the priming of T helper 1 cells through the inhibition of interleukin 12 secretion.

1996 • 349 citations

Inflammatory bowel disease-like enteritis and caecitis in a senescence accelerated mouse P1/Yit strain

1998 • 273 citations

On the role of tumor necrosis factor and receptors in models of multiorgan failure, rheumatoid arthritis, multiple sclerosis and inflammatory bowel disease

1999 • 263 citations

Hapten-induced model of murine inflammatory bowel disease: mucosa immune responses and protection by tolerance.

1996 • 243 citations

Cytokine imbalance and autoantibody production in T cell receptor-alpha mutant mice with inflammatory bowel disease.

1996 • 224 citations

The function of tumour necrosis factor and receptors in models of multi-organ inflammation, rheumatoid arthritis, multiple sclerosis and inflammatory bowel disease

1999 • 210 citations

Spontaneous, heritable colitis in a new substrain of C3H/HeJ mice

1994 • 204 citations

Severe colitis in mice with aberrant thymic selection

1995 • 186 citations

Spontaneously colitic C3H/HeJBir mice demonstrate selective antibody reactivity to antigens of the enteric bacterial flora.

1997 • 158 citations

Colitis in transgenic and knockout animals as models of human inflammatory bowel disease

1999 • 151 citations

Evidence that CD4⁺, but not CD8⁺ T cells are responsible for murine interleukin‐2‐deficient colitis

1995 • 144 citations

Intraepithelial Lymphocytes: Origins, Distribution, and Function

1998 • 143 citations

CURRENT THEORIES ON THE CAUSES OF INFLAMMATORY BOWEL DISEASE

1999 • 115 citations

Gi2? protein deficiency: A model for inflammatory bowel disease

1995 • 78 citations

III. Ontogeny and function of γδ T cells in the intestine

1998 • 71 citations

XI. Novel mouse models to study pathogenic mechanisms of Crohn's disease

2000 • 60 citations

Functional expression of a truncated Ca²⁺-activated Cl⁻channel and activation by phorbol ester

1998 • 59 citations

Polyclonal expansion of adoptively transferred CD4⁺ αβ T cells in the colonic lamina propria of scid mice with colitis

1996 • 56 citations

Alteration of a polyclonal to an oligoclonal immune response to cecal aerobic bacterial antigens in TCRα mutant mice with inflammatory bowel disease

1996 • 50 citations

Gut‐homing CD4⁺ T cell receptor αβ⁺ T cells in the pathogenesis of murine inflammatory bowel disease

1994 • 44 citations

Genetics of inflammatory bowel disease

1996 • 35 citations

Activation of CD4+ T lymphocytes form interleukin 2-deficient mice by costimulatory B7 molecules.

1996 • 31 citations

Genetics of Inflammatory Bowel Disease

1996 • 23 citations

Immunological Abnormality in C3H/HeJ Mice with Heritable Inflammatory Bowel Disease

1996 • 10 citations

Genetics of Inflammatory Bowel Disease. A Personal View on Progress and Prospects

1998 • 10 citations

Lack of linkage between MHC haplotype and ileitis in a spontaneous model of Crohn's disease

2000 • 3 citations