Pharmacogenomics and metabolite measurement for 6-mercaptopurine therapy in inflammatory bowel disease

Cortisone in Ulcerative Colitis

1955 • 2,701 citations

Classification of Inflammatory Bowel Disease

1989 • 1,995 citations

Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyltransferase activity.

1980 • 1,185 citations

Treatment of Crohn's Disease with 6-Mercaptopurine

1980 • 1,055 citations

Azathioprine and 6-Mercaptopurine in Crohn Disease

1995 • 966 citations

Molecular Diagnosis of Thiopurine S-Methyltransferase Deficiency: Genetic Basis for Azathioprine and Mercaptopurine Intolerance

1997 • 765 citations

6-Mercaptopurine in the Management of Inflammatory Bowel Disease: Short- and Long-Term Toxicity

1989 • 757 citations

Genetic variation in response to 6-mercaptopurine for childhood acute lymphoblastic leukaemia

1990 • 657 citations

The clinical pharmacology of 6-mercaptopurine

1992 • 640 citations

Genotypic analysis of thiopurine S-methyltransferase in patients with Crohn's disease and severe myelosuppression during azathioprine therapy

2000 • 620 citations

Pharmacogenetics of acute azathioprine toxicity: Relationship to thiopurine methyltransferase genetic polymorphism

1989 • 605 citations

A controlled double blind study of azathioprine in the management of Crohn's disease.

1995 • 583 citations

Bone marrow toxicity caused by azathioprine in inflammatory bowel disease: 27 years of experience.

1993 • 501 citations

Randomised controlled trial of azathioprine withdrawal in ulcerative colitis.

1992 • 458 citations

Altered mercaptopurine metabolism, toxic effects, and dosage requirement in a thiopurine methyltransferase-deficient child with acute lymphocytic leukemia

1991 • 396 citations

Thiopurine Methyltransferase Genotype Predicts Therapy-Limiting Severe Toxicity from Azathioprine

1998 • 380 citations

6-Mercaptopurine metabolism in Crohn's disease: correlation with efficacy and toxicity.

1996 • 334 citations

Thiopurine S-methyltransferase deficiency: two nucleotide transitions define the most prevalent mutant allele associated with loss of catalytic activity in Caucasians.

1996 • 321 citations

CONTROLLED TRIAL OF AZATHIOPRINE IN CROHN'S DISEASE

1971 • 316 citations

Thiopurine Methyltransferase Pharmacogenetics: Human Gene Cloning and Characterization of a Common Polymorphism

1996 • 310 citations

A review of immune modifier therapy for inflammatory bowel disease: azathioprine, 6-mercaptopurine, cyclosporine, and methotrexate.

1996 • 279 citations

Variable Bioavailability of Oral Mercaptopurine

1983 • 268 citations

Favorable effect of 6-Mercaptopurine on fistulae of Crohn's disease

1985 • 265 citations

Variable mercaptopurine metabolism and treatment outcome in childhood lymphoblastic leukemia.

1989 • 251 citations

Safety of azathioprine and 6-mercaptopurine in pediatric patients with inflammatory bowel disease

1998 • 241 citations

A Controlled Trial of Azathioprine in the Management of Chronic Ulcerative Colitis

1975 • 235 citations

Sulphasalazine inhibition of thiopurine methyltransferase: possible mechanism for interaction with 6‐mercaptopurine and azathioprine.

1995 • 226 citations

Mercaptopurine metabolism and risk of relapse in childhood lymphoblastic leukaemia

1994 • 218 citations

Congenital thiopurine methyltransferase deficiency and 6-mercaptopurine toxicity during treatment for acute lymphoblastic leukaemia.

1993 • 186 citations

Clinical classification of perianal Crohn's disease

1992 • 175 citations

Childhood leukaemia: a relationship between intracellular 6‐mercaptopurine metabolites and neutropenia

2004 • 161 citations

Long-term 6-mercaptopurine treatment in adolescents with Crohn's disease

1990 • 160 citations

Childhood leukaemia: a relationship between intracellular 6‐ mercaptopurine metabolites and neutropenia.

1983 • 155 citations

Olsalazine and 6-mercaptopurine-related bone marrow suppression: A possible drug-drug interaction

1997 • 153 citations

Mass Screening for Colorectal Cancer

1984 • 129 citations

The role of leukopenia in the 6-mercaptopurine-induced remission of refractory Crohn's disease.

1994 • 118 citations

The OMGE multinational inflammatory bowel disease survey 1976-1986. A further report on 3175 cases.

1988 • 115 citations

Clinical Implications of Thiopurine Methyltransferase-Optimization of Drug Dosage and Potential Drug Interactions

1998 • 115 citations

Pharmacokinetics and metabolism of thiopurines in children with acute lymphoblastic leukemia receiving 6-thioguanine versus 6-mercaptopurine

1998 • 115 citations

Azathioprine pharmacokinetics after intravenous, oral, delayed release oral and rectal foam administration.

1996 • 100 citations

Is 6-thioguanine more appropriate than 6-mercaptopurine for children with acute lymphoblastic leukaemia?

1993 • 98 citations

Nuclear DNA diversity in worldwide distributed human populations

1997 • 91 citations

Thiopurine methyltransferase. Aromatic thiol substrates and inhibition by benzoic acid derivatives.

1983 • 90 citations

The O.M.G.E. Multinational Inflammatory Bowel Disease Survey 1976-1982

1984 • 85 citations

Quantitation of 6-thioguanine in peripheral blood leukocyte DNA in Crohn's disease patients on maintenance 6-mercaptopurine therapy

1996 • 74 citations

Immunosuppressive therapy in pediatric inflammatory bowel disease: results of a survey of the North American Society for Pediatric Gastroenterology and Nutrition. Subcommittee on Immunosuppressive Use of the Pediatric IBD Collaborative Research Forum.

1993 • 64 citations

MONITORED HIGH-DOSE AZATHIOPRINE TREATMENT REDUCES ACUTE REJECTION EPISODES AFTER RENAL TRANSPLANTATION

1998 • 59 citations

Should 6- Thioguanine Nucleotides Be Monitored in Heart Transplant Recipients Given Azathioprine?

1996 • 54 citations

Formation and significance of 6-methylthiopurine ribonucleotide as a metabolite of 6-mercaptopurine.

1971 • 48 citations

Intraindividual variation in 6-mercaptopurine pharmacokinetics during oral maintenance therapy of children with acute lymphoblastic leukaemia

1991 • 24 citations

6-mercaptopurine (6MP)+ prednisone therapy for newly diagnosed pediatric Crohn's disease (CD): a prospective, multicenter, placebo-controlled clinical trial

1998 • 19 citations

Quantitation of 6-thioguanine in peripheral blood leukocyte DNA in Crohn's disease patients on maintenance 6-mercaptopurine therapy

1996 • 16 citations

RELATIONSHIP OF LEUKOPENIA TO 6MP INDUCED REMISSION OF CROHN'S DISEASE (CD)

1998 • 7 citations

Toxicities and infections associated with chronic 6-Mercaptopurine (6-MP) use in Crohn's disease (CD): do we need to discontinue treatment?

1998 • 4 citations

Deleted Work

1955 • 0 citations