Inflammatory bowel disease: Immunodiagnostics, immunotherapeutics, and ecotherapeutics

Acute-Phase Proteins and Other Systemic Responses to Inflammation

1999 • 6,324 citations

A Short-Term Study of Chimeric Monoclonal Antibody cA2 to Tumor Necrosis Factor α for Crohn's Disease

1997 • 3,152 citations

Infliximab for the Treatment of Fistulas in Patients with Crohn's Disease

1999 • 2,656 citations

Inflammatory bowel disease: Etiology and pathogenesis

1998 • 2,095 citations

An Essential Role for Interleukin 10 in the Function of Regulatory T Cells That Inhibit Intestinal Inflammation

1999 • 1,607 citations

Oral bacteriotherapy as maintenance treatment in patients with chronic pouchitis: A double-blind, placebo-controlled trial

2000 • 1,505 citations

Functional food science and gastrointestinal physiology and function

1998 • 1,434 citations

Treatment of Murine Colitis by Lactococcus lactis Secreting Interleukin-10

2000 • 1,406 citations

Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: Evidence in Crohn disease and experimental colitis in vivo

2000 • 1,255 citations

The indigenous gastrointestinal microflora

1996 • 1,149 citations

Non-pathogenic Escherichia coli versus mesalazine for the treatment of ulcerative colitis: a randomised trial

1999 • 1,106 citations

Oral gene delivery with chitosan–DNA nanoparticles generates immunologic protection in a murine model of peanut allergy

1999 • 1,100 citations

Pharmacogenomics and metabolite measurement for 6-mercaptopurine therapy in inflammatory bowel disease

2000 • 998 citations

Differentiation and reversal of malignant changes in colon cancer through PPARγ

1998 • 984 citations

Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease (IBD)

1995 • 965 citations

Early lesions of recurrent Crohn's disease caused by infusion of intestinal contents in excluded ileum

1998 • 854 citations

Double‐blind comparison of an oral Escherichia coli preparation and mesalazine in maintaining remission of ulcerative colitis

1997 • 780 citations

Lactobacillus species prevents colitis in interleukin 10 gene–deficient mice

1999 • 771 citations

Surrogate markers of intestinal inflammation are predictive of relapse in patients with inflammatory bowel disease

2000 • 760 citations

A novel therapy for colitis utilizing PPAR-γ ligands to inhibit the epithelial inflammatory response

1999 • 756 citations

Effect of faecal stream diversion on recurrence of Crohn's disease in the neoterminal ileum

1991 • 755 citations

A Comparison of Methotrexate with Placebo for the Maintenance of Remission in Crohn's Disease

2000 • 703 citations

Anti-Saccharomyces cerevisiae mannan antibodies combined with antineutrophil cytoplasmic autoantibodies in inflammatory bowel disease: prevalence and diagnostic role

1998 • 574 citations

Ecological control of the gastrointestinal tract. The role of probiotic flora

1998 • 500 citations

Long-term follow-up of patients with Crohn's disease treated with azathioprine or 6-mercaptopurine

1996 • 480 citations

Non-pathogenic bacteria elicit a differential cytokine response by intestinal epithelial cell/leucocyte co-cultures

2000 • 460 citations

Antitumor Necrosis Factor Therapy for Inflammatory Bowel Disease: A Review of Agents, Pharmacology, Clinical Results, and Safety

1999 • 459 citations

Animal models of mucosal inflammation and their relation to human inflammatory bowel disease

1999 • 456 citations

Mucosal antibodies in inflammatory bowel disease are directed against intestinal bacteria.

1996 • 437 citations

CD4+ T Cells Reactive to Enteric Bacterial Antigens in Spontaneously Colitic C3H/HeJBir Mice: Increased T Helper Cell Type 1 Response and Ability to Transfer Disease

1998 • 393 citations

New insights into the biology of the acute phase response.

1999 • 389 citations

Gastrointestinal Illness and the Biopsychosocial Model

1998 • 388 citations

Lactobacillus casei strain GG reverses increased intestinal permeability induced by cow milk in suckling rats

1993 • 382 citations

Diagnostic accuracy of serological assays in pediatric inflammatory bowel disease

1998 • 381 citations

Tolerance towards resident intestinal flora in mice is abrogated in experimental colitis and restored by treatment with interleukin‐10 or antibodies to interleukin‐12

1996 • 358 citations

Resistance of Crohn’s Disease T Cells to Multiple Apoptotic Signals Is Associated with a Bcl-2/Bax Mucosal Imbalance

1999 • 347 citations

Thalidomide therapy for patients with refractory Crohn's disease: An open-label trial

1999 • 335 citations

A major role for matrix metalloproteinases in T cell injury in the gut.

1997 • 329 citations

Crohn's disease and cancer: A population-based cohort study

1994 • 311 citations

Prophylaxis of postoperative relapse in Crohn's disease with mesalamine: European cooperative Crohn's disease study VI

2000 • 307 citations

The effects of Lactobacillus strains and oat fiber on methotrexate- induced enterocolitis in rats

1996 • 305 citations

Perinuclear antineutrophil cytoplasmic antibodies in patients with Crohn's disease define a clinical subgroup

1996 • 299 citations

An open-label pilot study of low-dose thalidomide in chronically active, steroid-dependent Crohn's disease

1999 • 290 citations

Lamina propria T cells in Crohn's disease and other gastrointestinal inflammation show defective CD2 pathway-induced apoptosis

1999 • 269 citations

Increased incidence of non-Hodgkin's lymphoma in inflammatory bowel disease patients on immunosuppressive therapy but overall risk is low

2000 • 265 citations

T cell specificity and cross reactivity towards enterobacteria,Bacteroides,Bifidobacterium, and antigens from resident intestinal flora in humans

1999 • 261 citations

The role of CD4+ lymphocytes in the susceptibility of mice to stress-induced reactivation of experimental colitis

1999 • 255 citations

Tumour necrosis factor α and interleukin 1β in relapse of Crohn's disease

1999 • 255 citations

Therapy of inflammatory bowel disease

2000 • 248 citations

Lack of effect of intravenous administration on time to respond to azathioprine for steroid-treated Crohn's disease

1999 • 247 citations

Extracolonic malignancies in inflammatory bowel disease

1991 • 235 citations

Distinct cytokine patterns in early and chronic ileal lesions of Crohn's disease

1997 • 228 citations

Inhibition of proinflammatory molecule production by adenovirus-mediated expression of a nuclear factor kappaB super-repressor in human intestinal epithelial cells.

1998 • 224 citations

Identification of a novel bacterial sequence associated with Crohn's disease

2000 • 216 citations

The relationship between infliximab treatment and lymphoma in Crohn's disease

1999 • 208 citations

Oral contraceptive use and smoking are risk factors for relapse in Crohn's disease

1998 • 206 citations

Probiotics and Inflammatory Bowel Disease: Is There a Scientific Rationale?

2000 • 204 citations

Role of the faecal stream in the maintenance of Crohn's colitis.

1985 • 203 citations

Randomised trial of mycophenolate mofetil versus azathioprine for treatment of chronic active Crohn’s disease

1999 • 201 citations

A Preliminary Study of Growth Hormone Therapy for Crohn's Disease

2000 • 201 citations

The Effect of Exogenous Administration ofLactobacillus reuteriR2LC and Oat Fiber on Acetic Acid-Induced Colitis in the Rat

1993 • 196 citations

Relationship of extraintestinal involvements in inflammatory bowel disease: new insights into autoimmune pathogenesis.

1999 • 187 citations

Functional Foods and Health Promotion

1999 • 168 citations

Inhibition of Proinflammatory Molecule Production by Adenovirus-Mediated Expression of a Nuclear Factor κB Super-Repressor in Human Intestinal Epithelial Cells

1998 • 161 citations

Immunity and probiotics

1999 • 157 citations

Imbalance of stromelysin-1 and TIMP-1 in the mucosal lesions of children with inflammatory bowel disease

2000 • 152 citations

The Neglected Organ: Bacterial Flora Has a Crucial Immunostimulatory Role

1992 • 149 citations

Interleukin 10 gene transfer prevents experimental colitis in rats

2000 • 149 citations

Familial expression of anti-Saccharomyces cerevisiae mannan antibodies in affected and unaffected relatives of patients with Crohn's disease

2000 • 146 citations

Peroral gene therapy of lactose intolerance using an adeno-associated virus vector

1998 • 143 citations

Azathioprine: State of the Art in Inflammatory Bowel Disease

1998 • 140 citations

Lymphoma in inflammatory bowel disease

1992 • 138 citations

Probiotics, prebiotics or `conbiotics'?

1998 • 137 citations

An International Survey of The Use and Attitudes Regarding Alternative Medicine by Patients With Inflammatory Bowel Disease

1999 • 136 citations

Epithelial cell growth and differentiation. III. Promoting diversity in the intestine: conversations between the microflora, epithelium, and diffuse GALT

1997 • 121 citations

Therapeutic effects of interleukin-4 gene transfer in experimental inflammatory bowel disease.

1997 • 116 citations

Brief Report: Treatment of Chronic Inflammatory Bowel Disease in Glycogen Storage Disease Type Ib with Colony-Stimulating Factors

1992 • 116 citations

Serologic testing for inflammatory bowel disease

1999 • 115 citations

The Role of the Fecal Stream in Crohnʼs Disease: An Historical and Analytic Review

1998 • 108 citations

CC-3052: a water-soluble analog of thalidomide and potent inhibitor of activation-induced TNF-alpha production.

1998 • 106 citations

Stimulation of transforming growth factor β1 by enteric bacteria in the pathogenesis of rat intestinal fibrosis

1998 • 96 citations

Azathioprine: an Update on Clinical Efficacy and Safety in Inflammatory Bowel Disease

1999 • 88 citations

Medical Therapy for Induction and Maintenance of Remission in Pouchitis: A Systematic Review

1999 • 88 citations

Suppression of T cell–mediated injury in human gut by interleukin 10: Role of matrix metalloproteinases

1998 • 87 citations

CC-3052: A Water-Soluble Analog of Thalidomide and Potent Inhibitor of Activation-Induced TNF-α Production

1998 • 80 citations

Increased mucosal production of granulocyte colony‐stimulating factor is related to a delay in neutrophil apoptosis in Inflammatory Bowel disease

1999 • 72 citations

Bacterial Regulation of Intestinal Immune Responses

2000 • 72 citations

Biologic therapy for inflammatory bowel disease

1997 • 58 citations

Commensal bacteria as targets in Crohn's disease

2000 • 58 citations

V. Mechanisms of immunologic sensation of intestinal contents

2000 • 56 citations

Brain-gut axis and mucosal immunity: a perspective on mucosal psychoneuroimmunology.

1999 • 56 citations

Growth hormone as an immunomodulating therapeutic agent

2000 • 49 citations

Mesalamine for the prevention of postoperative recurrence: Is nearly there the same as being there?

2000 • 42 citations

Biologic Therapy for Inflammatory Bowel Disease

1997 • 41 citations

Cyclic Neutropenia in Crohn's Ileocolitis: Efficacy of Granulocyte Colony-Stimulating Factor

1997 • 34 citations

Immunostimulation in Crohn's disease: Results of a pilot study of G-CSF (r-metHuG-CSF) in mucosal and fistulizing Crohn's disease

2000 • 32 citations

Microbe-host interactions in the alimentary tract: the gateway to understanding inflammatory bowel disease

2000 • 30 citations

Induction and modulation of gastrointestinal inflammation

1998 • 30 citations

Probiotic therapy with E. coli for ulcerative colitis: Take the good with the bad

2000 • 28 citations

Discovering the cause of inflammatory bowel disease: lessons from animal models

2000 • 25 citations

Cytokine-based therapies in inflammatory bowel disease

1999 • 23 citations

Immunosuppressors for Inflammatory Bowel Disease: How Long Is Long Enough?

2000 • 19 citations

Viral vectors expressing immunoregulatory cytokines to treat inflammatory bowel disease

1998 • 15 citations

Antibiotics are effective therapy for Crohn's disease

1997 • 14 citations

Infliximab Is the Drug We Have Been Waiting For in Crohnʼs Disease

2000 • 12 citations

Antibiotics are not effective therapy for Crohn's disease (time to remove the rose-coloured glasses)

1997 • 11 citations

Antibiotics Are Not Effective Therapy for Crohnʼs Disease (Time to Remove the Rose-Coloured Glasses)

1997 • 10 citations

Antibiotics Are Effective Therapy for Crohnʼs Disease

1997 • 9 citations

Response to anti-tnfatreatment is associated with the TNFA-308*1 allele

2000 • 9 citations

Enhanced survival and mucosal repair following DSS colitis in transgenic mice that overexpress bovine growth hormone

2000 • 4 citations

ASCA and panca do not predict response to anti-TNFA (Remicade®) treatment

2000 • 4 citations

Evaluation of TNF microsatellites and SNPS in a cohort of chronic active, therapy refractory Crohn's disease patients treated with anti TNF-alpha

2000 • 3 citations

The gastrointestinal system and psychological factors

1999 • 2 citations