Serum MMP-2 and MMP-9 are elevated in different multiple sclerosis subtypes

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Principles of albumin and IgG analyses in neurological disorders. I. Establishment of reference values

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1994 • 680 citations

Interferon β‐1b decreases the migration of T lymphocytes in vitro: Effects on matrix metalloproteinase‐9

1996 • 363 citations

Reversal of experimental autoimmune encephalomyelitis with a hydroxamate inhibitor of matrix metalloproteases.

1994 • 338 citations

Principles of albumin and IgG analyses in neurological disorders. III. Evaluation of IgG synthesis within the central nervous system in multiple sclerosis

1977 • 331 citations

Interferon beta‐1b inhibits gelatinase secretion and in vitro migration of human T cells: A possible mechanism for treatment efficacy in multiple sclerosis

1996 • 302 citations

Principles of albumin and IgG analyses in neurological disorders. III. Evaluation of IgG synthesis within the central nervous system in multiple sclerosis

1977 • 297 citations

The Role of Matrix Metalloproteinase-2 and Matrix Metalloproteinase-9 in Antibody-Induced Arthritis

2002 • 292 citations

Matrix Metalloproteinases in the Normal Human Central Nervous System, Microglial Nodules, and Multiple Sclerosis Lesions

1996 • 290 citations

Gelatinase in the cerebrospinal fluid of patients with multiple sclerosis and other inflammatory neurological disorders

1992 • 286 citations

Matrix metalloproteinases, tumor necrosis factor and multiple sclerosis: an overview

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Effect of steroids on CSF matrix metalloproteinases in multiple sclerosis

1996 • 278 citations

Cytokine regulation of matrix metalloproteinase activity and its regulatory dysfunction in disease.

1995 • 273 citations

Differential matrix metalloproteinase expression in cases of multiple sclerosis and stroke

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Matrix Metalloproteinase (MMP)-8 and MMP-9 in Cerebrospinal Fluid during Bacterial Meningitis: Association with Blood-Brain Barrier Damage and Neurological Sequelae

2000 • 252 citations

Mechanisms of action of glatiramer acetate in multiple sclerosis

2001 • 252 citations

Matrix metalloproteinases: multifunctional effectors of inflammation in multiple sclerosis and bacterial meningitis

2001 • 251 citations

Matrix metalloproteinase-9 (gelatinase B) is selectively elevated in CSF during relapses and stable phases of multiple sclerosis

1998 • 248 citations

The Expression of Tissue-type Plasminogen Activator, Matrix Metalloproteases and Endogenous Inhibitors in the Central Nervous System in Multiple Sclerosis

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Differential mechanisms of action of interferon-β and glatiramer acetate in MS

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Serum MMP-9 and TIMP-1 levels are related to MRI activity in relapsing multiple sclerosis

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Serum gelatinase B, TIMP-1 and TIMP-2 levels in multiple sclerosis

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Steps Involved in Activation of the Pro-matrix Metalloproteinase 9 (Progelatinase B)-Tissue Inhibitor of Metalloproteinases-1 Complex by 4-Aminophenylmercuric Acetate and Proteinases

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Age‐related disability in multiple sclerosis

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Matrix metalloproteinases in inflammatory demyelination

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The role of matrix metalloproteinases in autoimmune damage to the central and peripheral nervous system

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Activation of the 92-kDa Gelatinase by Stromelysin and 4-Aminophenylmercuric Acetate

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Matrix metalloproteinase-9 and -7 are regulated in experimental autoimmune encephalomyelitis

1998 • 166 citations

The expression profile of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) in lesions and normal appearing white matter of multiple sclerosis

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Suppression of experimental allergic encephalomyelitis in the Lewis rat by the matrix metalloproteinase inhibitor Ro31-9790

1995 • 146 citations

T-cell- and macrophage-mediated axon damage in the absence of a CNS-specific immune response: involvement of metalloproteinases

2001 • 144 citations

Changes of serum sICAM-1 and MMP-9 induced by rIFNβ-1b treatment in relapsing-remitting MS

1999 • 127 citations

HIV-1 Tat neurotoxicity is prevented by matrix metalloproteinase inhibitors

2001 • 127 citations

Matrix metalloproteinases and their tissue inhibitors as markers of disease subtype and response to interferon‐β therapy in relapsing and secondary‐progressive multiple sclerosis patients

2001 • 125 citations

Effective treatment of models of multiple sclerosis by matrix metalloproteinase inhibitors

1998 • 124 citations

Matrix metalloproteinases and tissue inhibitors of metalloproteinases in viral meningitis: upregulation of MMP-9 and TIMP-1 in cerebrospinal fluid

1998 • 109 citations

Intrathecal synthesis of matrix metalloproteinase-9 in patients with multiple sclerosis: implication for pathogenesis

2002 • 103 citations

Expression of matrix metalloproteinase-9 and its inhibitors in mononuclear blood cells of patients with multiple sclerosis

1999 • 95 citations

Matrix metalloproteinase-9 (MMP-9) in human cerebrospinal fluid (CSF): elevated levels are primarily related to CSF cell count

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Evaluation of gelatinases and IL‐6 in the cerebrospinal fluid of patients with optic neuritis, multiple sclerosis and other inflammatory neurological diseases

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Multiple sclerosis: elevated expression of matrix metalloproteinases in blood monocytes

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Age Dependence of Clinical and Pathological Manifestations of Autoimmune Demyelination

1999 • 64 citations

Metalloproteinases and their Tissue Inhibitors in Multiple Sclerosis

1999 • 63 citations

Enhancement frequency decreases with increasing age in relapsing-remitting multiple sclerosis

2001 • 58 citations

Monocyte-derived dendritic cells express and secrete matrix-degrading metalloproteinases and their inhibitors and are imbalanced in multiple sclerosis

2002 • 56 citations

Matrix metalloproteinases in multiple sclerosis

1999 • 22 citations

Matrix metalloproteinases in multiple sclerosis: Is it time for a treatment trial?

2001 • 22 citations

Toxicity in a double-blind, placebo-controlled pilot trial with D-penicillamine and metacycline in secondary progressive multiple sclerosis

1998 • 21 citations

Niridazole Suppression of Experimental Allergic Encephalomyelitis in Lewis Rats

1977 • 13 citations