Revisiting retinoblastoma protein phosphorylation during the mammalian cell cycle

Cancer Cell Cycles

1996 • 5,379 citations

The retinoblastoma protein and cell cycle control

1995 • 4,873 citations

Inhibitors of mammalian G1 cyclin-dependent kinases.

1995 • 3,258 citations

The Human Papilloma Virus-16 E7 Oncoprotein Is Able to Bind to the Retinoblastoma Gene Product

1989 • 3,036 citations

A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma

1986 • 2,968 citations

Expression of recessive alleles by chromosomal mechanisms in retinoblastoma

1983 • 1,952 citations

SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene

1988 • 1,490 citations

Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product

1988 • 1,440 citations

Human Retinoblastoma Susceptibility Gene: Cloning, Identification, and Sequence

1987 • 1,436 citations

The retinoblastoma protein is phosphorylated during specific phases of the cell cycle

1989 • 1,031 citations

Cdk Phosphorylation Triggers Sequential Intramolecular Interactions that Progressively Block Rb Functions as Cells Move through G1

1999 • 1,028 citations

Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation

1989 • 990 citations

The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element

1989 • 931 citations

Abnormalities in Structure and Expression of the Human Retinoblastoma Gene in SCLC

1988 • 905 citations

Suppression of the Neoplastic Phenotype by Replacement of the RB Gene in Human Cancer Cells

1988 • 832 citations

Growth inhibition by TGF-β linked to suppression of retinoblastoma protein phosphorylation

1990 • 812 citations

Structural Evidence for the Authenticity of the Human Retinoblastoma Gene

1987 • 809 citations

Genetic Alterations of Cyclins, Cyclin-Dependent Kinases, and Cdk Inhibitors in Human Cancer

1996 • 751 citations

SV40 large T antigen binds preferentially to an underphosphorylated member of the retinoblastoma susceptibility gene product family

1989 • 508 citations

Differential Phosphorylation of the Retinoblastoma Protein by G1/S Cyclin-dependent Kinases

1997 • 486 citations

Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F

1997 • 468 citations

Cell Cycle-Dependent Regulation of Phosphorylation of the Human Retinoblastoma Gene Product

1989 • 457 citations

Point Mutational Inactivation of the Retinoblastoma Antioncogene

1989 • 427 citations

Structural Rearrangement of the Retinoblastoma Gene in Human Breast Carcinoma

1988 • 423 citations

The retinoblastoma susceptibility gene product undergoes cell cycle-dependent dephosphorylation and binding to and release from SV40 large T

1990 • 402 citations

Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation.

1997 • 396 citations

Control of pRB phosphorylation

1998 • 389 citations

Cyclin E-induced S phase without activation of the pRb/E2F pathway.

1997 • 381 citations

INDUCTION OF CELLULAR DNA SYNTHESIS BY POLYOMA VIRUS

1965 • 304 citations

Altered expression of the retinoblastoma (RB) gene in small-cell carcinoma of the lung.

1988 • 247 citations

Molecular detection of deletions involving band q14 of chromosome 13 in retinoblastomas.

1986 • 240 citations

Cyclin E and c-Myc promote cell proliferation in the presence of p16INK4a and of hypophosphorylated retinoblastoma family proteins

1997 • 206 citations

Chromosomal reorganization for the expression of recessive mutation of retinoblastoma susceptibility gene in the development of osteosarcoma.

1988 • 204 citations

Biological activity of purified simian virus 40 T antigen proteins.

1978 • 197 citations

A unifying model for the G1 period in prokaryotes and eukaryotes

1979 • 156 citations

The role of RB in cell cycle control

1995 • 156 citations

Expression and state of phosphorylation of the retinoblastoma susceptibility gene product in cycling and noncycling human hematopoietic cells.

1990 • 149 citations

Distinct sub-populations of the retinoblastoma protein show a distinct pattern of phosphorylation.

1994 • 148 citations

Structure and partial genomic sequence of the human retinoblastoma susceptibility gene

1989 • 139 citations

Mapping of early SV40-specific functions by microinjection of different early viral DNA fragments

1978 • 113 citations

The retinoblastoma gene and gene product.

1992 • 111 citations

Induction of DNA synthesis by SV40.

1966 • 109 citations

High Molecular Weight Protein Phosphatase Type 1 Dephosphorylates the Retinoblastoma Protein

1997 • 105 citations

The retinoblastoma susceptibility gene product: a characteristic pattern in normal cells and abnormal expression in malignant cells.

1989 • 104 citations

Cell-cycle regulation of gene expression by transcriptional repression

1997 • 103 citations

Binding of the Rb1 protein to E1A products is required for adenovirus transformation.

1989 • 101 citations

Mutational analysis of simian virus 40 T antigen: stimulation of cellular DNA synthesis and activation of rRNA genes by mutants with deletions in the T-antigen gene.

1983 • 99 citations

Perturbation of cell cycle regulators in human cancer.

1996 • 96 citations

Constitutively active protein phosphatase 1α causes Rb-dependent G1 arrest in human cancer cells

1997 • 94 citations

Antibodies detecting abnormalities of the retinoblastoma susceptibility gene product (pp110RB) in osteosarcomas and synovial sarcomas.

1989 • 88 citations

Characterization and biological activity of cloned simian virus 40 DNA fragments.

1981 • 82 citations

Cancer and the cell cycle

1999 • 76 citations

Stimulation of DNA synthesis in mouse cell line 3T3 by Simian virus 40.

1966 • 74 citations

Distinct roles for Sp1 and E2F sites in the growth/cell cycle regulation of the DHFR promoter

1997 • 71 citations

Bacterial growth and division

1991 • 67 citations

Mutational Analysis of Simian Virus 40 T Antigen: Stimulation of Cellular DNA Synthesis and Activation of rRNA Genes by Mutants with Deletions in the T-Antigen Gene

1983 • 50 citations

Mammalian cells are not synchronized in G₁‐phase by starvation or inhibition: considerations of the fundamental concept of G₁‐phase synchronization

1998 • 47 citations

Characterization of the mitotic phase pRb-directed protein phosphatase activity

1997 • 44 citations

On the proposal of a G0 phase and the restriction point

1998 • 43 citations

Balancing proliferation and apoptosis in vivo: the Goldilocks theory of E2F/DP action

1999 • 42 citations

Studies on the human retinoblastoma susceptibility gene

1988 • 37 citations

On G₀ and cell cycle controls

1987 • 37 citations

The phosphorylation state of the retinoblastoma (RB) protein in G0/G1 is dependent on growth status.

1991 • 35 citations

The Continuum model and G1-control of the mammalian cell cycle

2000 • 34 citations

Hypophosphorylation of the RB Protein in S and G2 as Well as G1 during Growth Arrest

1998 • 29 citations

The continuum model and c-myc synthesis during the division cycle

1988 • 29 citations

Simian Virus 40 Transformation and the Period of Cellular Deoxyribonucleic Acid Synthesis

1967 • 25 citations

On the Interpretation of the Shortening of the G1-Phase by Overexpression of Cyclins in Mammalian Cells

1998 • 21 citations

Phosphorylation‐Dephosphorylation of Retinoblastoma Protein Not Necessary for Passage through the Mammalian Cell Division Cycle

1999 • 13 citations

G1 and S Phase Gene Expression Cannnot Be Analyzed in Mammalian Cells Synchronized by Inhibition

1997 • 10 citations

INDUCTION OF CELLULAR DNA SYNTHESIS BY POLYOMA VIRUS

1965 • 3 citations