High Molecular Weight Protein Phosphatase Type 1 Dephosphorylates the Retinoblastoma Protein

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

The retinoblastoma protein and cell cycle control

1995 • 4,873 citations

A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma

1986 • 2,968 citations

Protein kinases and phosphatases: The Yin and Yang of protein phosphorylation and signaling

1995 • 2,907 citations

Universal control mechanism regulating onset of M-phase

1990 • 2,882 citations

THE STRUCTURE AND REGULATION OF PROTEIN PHOSPHATASES

1989 • 2,518 citations

Determination of molecular weights and frictional ratios of proteins in impure systems by use of gel filtration and density gradient centrifugation. Application to crude preparations of sulfite and hydroxylamine reductases

1966 • 2,239 citations

Mammalian G1 cyclins

1993 • 1,990 citations

Human Retinoblastoma Susceptibility Gene: Cloning, Identification, and Sequence

1987 • 1,436 citations

Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4

1993 • 1,258 citations

Functional interactions of the retinoblastoma protein with mammalian D-type cyclins

1993 • 1,047 citations

Regulation of retinoblastoma protein functions by ectopic expression of human cyclins

1992 • 1,031 citations

The retinoblastoma protein is phosphorylated during specific phases of the cell cycle

1989 • 1,031 citations

Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation

1989 • 990 citations

The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element

1989 • 931 citations

Growth inhibition by TGF-β linked to suppression of retinoblastoma protein phosphorylation

1990 • 812 citations

Physical interaction of the retinoblastoma protein with human D cyclins

1993 • 780 citations

Tumor suppressor genes

1991 • 775 citations

The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle

1991 • 708 citations

Protein serine/threonine phosphatases: structure, regulation, and functions in cell growth

1993 • 662 citations

Serine/threonine protein phosphatases

1995 • 635 citations

Frequent inactivation of the retinoblastoma anti-oncogene is restricted to a subset of human tumor cells.

1990 • 543 citations

SV40 large T antigen binds preferentially to an underphosphorylated member of the retinoblastoma susceptibility gene product family

1989 • 508 citations

The fission yeast dis2+ gene required for chromosome disjoining encodes one of two putative type 1 protein phosphatases

1989 • 486 citations

An improved procedure for identifying and quantitating protein phosphatases in mammalian tissues

1989 • 482 citations

Cell Cycle-Dependent Regulation of Phosphorylation of the Human Retinoblastoma Gene Product

1989 • 457 citations

[37] Protein phosphatase-1 and protein phosphatase-2A from rabbit skeletal muscle

1988 • 418 citations

The retinoblastoma susceptibility gene product undergoes cell cycle-dependent dephosphorylation and binding to and release from SV40 large T

1990 • 402 citations

The control of protein phosphatase‐1 by targetting subunits

1992 • 376 citations

The retinoblastoma protein is phosphorylated on multiple sites by human cdc2.

1991 • 343 citations

Distinct, essential roles of type 1 and 2A protein phosphatases in the control of the fission yeast cell division cycle

1990 • 339 citations

The bimG gene of Aspergillus nidulans, required for completion of anaphase, encodes a homolog of mammalian phosphoprotein phosphatase 1

1989 • 326 citations

Retinoblastoma cancer suppressor gene product is a substrate of the cell cycle regulator cdc2 kinase.

1991 • 304 citations

The Structure, Role, and Regulation of Type 1 Protein Phosphatases

1992 • 295 citations

One of the protein phosphatase 1 isoenzymes in Drosophila is essential for mitosis

1990 • 291 citations

Specific enzymatic dephosphorylation of the retinoblastoma protein.

1993 • 258 citations

The retinoblastoma-susceptibility gene product becomes phosphorylated in multiple stages during cell cycle entry and progression.

1992 • 239 citations

Identification of Members of the Protein Phosphatase 1 Gene Family in the Rat and Enhanced Expression of Protein Phosphatase 1α Gene in Rat Hepatocellular Carcinomas

1990 • 227 citations

[33] Classification of protein- serine/threonine phosphatases: identification and quantitation in cell extracts

1991 • 223 citations

The Retinoblastoma Protein: More than a Tumor Suppressor

1994 • 205 citations

Protein phosphatase type 1 in mammalian cell mitosis: chromosomal localization and involvement in mitotic exit.

1992 • 198 citations

Involvement of a type 1 protein phosphatase encoded by bws1+ in fission yeast mitotic control

1989 • 188 citations

Purification, properties, and substrate specificities of phosphoprotein phosphatase(s) from rabbit liver.

1976 • 178 citations

Regulation of cell cycle progression and nuclear affinity of the retinoblastoma protein by protein phosphatases.

1993 • 158 citations

Expression and state of phosphorylation of the retinoblastoma susceptibility gene product in cycling and noncycling human hematopoietic cells.

1990 • 149 citations

Further studies of the helix dipole model: Effects of a free α‐NH₃⁺ or α‐COO⁻ group on helix stability

1989 • 145 citations

The retinoblastoma gene: role in cell cycle control and cell differentiation

1993 • 132 citations

Putting it on and taking it off: Phosphoprotein phosphatase involvement in cell cycle regulation

1989 • 119 citations

Handbook of Biochemistry

2010 • 118 citations

Studies in the Physical Chemistry of Amino Acids, Peptides and Related Substances. I. The Apparent Molal Volume and the Electrostriction of the Solvent

1934 • 102 citations

Subunit Structure and Regulation of Protein Phosphatase-1 in Rat Liver Nuclei

1995 • 99 citations

Rabbit muscle phosphorylase phosphatase. 1. Purification and chemical properties

1977 • 97 citations

Identification of PP1 Catalytic Subunit Isotypes PP1γ1, Pp1δ and Pp1α in Various Rat Tissues

1993 • 90 citations

[34] Preparation of low-molecular -weight forms of rabbit muscle protein phosphatase

1988 • 72 citations

Cyclin‐dependent kinases and pRb: regulators of the proliferation‐differentiation switch

1995 • 39 citations

The phosphorylation state of the retinoblastoma (RB) protein in G0/G1 is dependent on growth status.

1991 • 35 citations

Control and activity of type-1 serine/threonine protein phosphatase during the cell cycle

1995 • 28 citations

[33] Preparation of protein phosphatase-resistant substrates using adenosine 5′-O-(γ-Thio)triphosphate

1988 • 18 citations

Subunit structure and properties of the glycogen-bound phosphoprotein phosphatase from skeletal muscle.

1986 • 18 citations