The Continuum model and G1-control of the mammalian cell cycle

A Restriction Point for Control of Normal Animal Cell Proliferation

1974 • 1,389 citations

Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts.

1993 • 1,057 citations

The retinoblastoma protein is phosphorylated during specific phases of the cell cycle

1989 • 1,031 citations

Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation

1989 • 990 citations

The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element

1989 • 931 citations

Do Cells Cycle?

1973 • 885 citations

Cyclin-Dependent Regulation of G ₁ in Mammalian Fibroblasts

1993 • 767 citations

Mammalian Cell Fusion : Studies on the Regulation of DNA Synthesis and Mitosis

1970 • 759 citations

Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system.

1994 • 659 citations

Thymine deficiency and the normal DNA replication cycle. I

1961 • 601 citations

Cell Cycle-Dependent Regulation of Phosphorylation of the Human Retinoblastoma Gene Product

1989 • 457 citations

Levels of c-myc oncogene mRNA are invariant throughout the cell cycle

1985 • 426 citations

The retinoblastoma susceptibility gene product undergoes cell cycle-dependent dephosphorylation and binding to and release from SV40 large T

1990 • 402 citations

Overexpression of cyclin D1 in rat fibroblasts causes abnormalities in growth control, cell cycle progression and gene expression.

1993 • 393 citations

Cyclin D1 induction in breast cancer cells shortens G1 and is sufficient for cells arrested in G1 to complete the cell cycle.

1994 • 377 citations

c-myc oncogene protein synthesis is independent of the cell cycle in human and avian cells

1985 • 371 citations

Kinetic analysis of regulatory events in G1 leading to proliferation or quiescence of Swiss 3T3 cells.

1985 • 370 citations

On the Bacterial Life Sequence

1968 • 307 citations

Metabolism of c-myc gene products: c-myc mRNA and protein expression in the cell cycle.

1985 • 271 citations

Cell Cycle Control

1995 • 259 citations

The retinoblastoma-susceptibility gene product becomes phosphorylated in multiple stages during cell cycle entry and progression.

1992 • 239 citations

Cytometry of cyclin proteins

1996 • 216 citations

Initiation of Deoxyribonucleic Acid Replication in Escherichia coli B/r: Chronology of Events and Transcriptional Control of Initiation

1972 • 159 citations

The role of RB in cell cycle control

1995 • 156 citations

A unifying model for the G1 period in prokaryotes and eukaryotes

1979 • 156 citations

What Mad Pursuit

1988 • 150 citations

Initiation of DNA replication in Escherichia coli 15T−: Chronological dissection of three physiological processes required for initiation

1969 • 121 citations

Bacterial Growth and Division: Biochemistry and Regulation of Prokaryotic and Eukaryotic Division Cycles

1991 • 96 citations

The Continuum Model: Statistical implications

1982 • 68 citations

Bacterial growth and division: Biochemistry and regulation of prokaryotic and eukaryotic division cycles

1992 • 68 citations

Genetic analysis of the G1 period: Isolation of mutants (or variants) with a G1 period from a Chinese hamster cell line lacking G1

1978 • 53 citations

Mammalian cells are not synchronized in G₁‐phase by starvation or inhibition: considerations of the fundamental concept of G₁‐phase synchronization

1998 • 47 citations

On the proposal of a G0 phase and the restriction point

1998 • 43 citations

Consequences of parental exposure to serum-free medium for progeny cell division

1985 • 40 citations

On G₀ and cell cycle controls

1987 • 37 citations

Unscheduled expression of cyclins D1 and D3 in human tumour cell lines

1996 • 36 citations

Transcriptional control of the Htf9-A/RanBP-1 gene during the cell cycle.

1995 • 34 citations

The central dogma of cell biology

1981 • 30 citations

The continuum model and c-myc synthesis during the division cycle

1988 • 29 citations

The G1 distribution of “G1-less” V79 Chinese hamster cells

1983 • 24 citations

Comment on the Use of Chloramphenicol to Study the Initiation of Deoxyribonucleic Acid Synthesis

1971 • 24 citations

Length extension in growing yeast: is growth exponential? - Yes

1998 • 22 citations

On the Interpretation of the Shortening of the G1-Phase by Overexpression of Cyclins in Mammalian Cells

1998 • 21 citations

The continuum model: An experimental and theoretical challenge to the G1 model of cell cycle regulation

1989 • 19 citations

Cell cycle progression and cell grow-th in tnatntnalian cells: kinetic aspects of transition events

1995 • 17 citations

A criterion for using chloramphenicol to define different processes in the initiation of DNA synthesis in bacteria

1974 • 12 citations

G1 and S Phase Gene Expression Cannnot Be Analyzed in Mammalian Cells Synchronized by Inhibition

1997 • 10 citations

A critique of the use of DNA synthesis as a measure of the effect of mitogens on lymphocytes

1982 • 6 citations

Cell cycle controls in eukaryotic cells: A reply

1987 • 4 citations