Distinct roles for Sp1 and E2F sites in the growth/cell cycle regulation of the DHFR promoter

Retinoblastoma protein switches the E2F site from positive to negative element

1992 • 663 citations

Mechanism of active transcriptional repression by the retinoblastoma protein

1995 • 494 citations

Interaction of Sp1 with the Growth- and Cell Cycle-Regulated Transcription Factor E2F

1996 • 343 citations

Transcription Factor E2F Is Required for Efficient Expression of the Hamster Dihydrofolate Reductase Gene In Vitro and In Vivo

1989 • 292 citations

Sp3 Is a Bifunctional Transcription Regulator with Modular Independent Activation and Repression Domains

1997 • 284 citations

Transcriptional initiation is controlled by upstream GC-box interactions in a TATAA-less promoter.

1990 • 270 citations

Cell Cycle-Regulated Association of E2F1 and Sp1 Is Related to Their Functional Interaction

1996 • 268 citations

The retinoblastoma gene product regulates Sp1-mediated transcription.

1992 • 253 citations

Introduction to the E2F Family: Protein Structure and Gene Regulation

1996 • 249 citations

Transcription from TATA-less promoters: dihydrofolate reductase as a model.

1993 • 241 citations

Dephosphorylation of Sp1 by Protein Phosphatase 1 Is Involved in the Glucose-mediated Activation of the Acetyl-CoA Carboxylase Gene

1996 • 228 citations

The Accumulation of an E2F-p130 Transcriptional Repressor Distinguishes a G₀ Cell State From a G₁ Cell State

1996 • 222 citations

Sp1 Is Phosphorylated and Its DNA Binding Activity Down-regulated upon Terminal Differentiation of the Liver

1995 • 210 citations

Sp-1 binds promoter elements regulated by the RB protein and Sp-1-mediated transcription is stimulated by RB coexpression.

1993 • 203 citations

Sp1 Trans-Activation of Cell Cycle Regulated Promoters Is Selectively Repressed by Sp3

1995 • 193 citations

The HIP1 Binding Site Is Required for Growth Regulation of the Dihydrofolate Reductase Gene Promoter

1992 • 172 citations

Transcriptional regulation of mouse dihydrofolate reductase in the cell cycle.

1985 • 165 citations

In Vivo Structure of the Human cdc2 Promoter: Release of a p130–E2F-4 Complex from Sequences Immediately Upstream of the Transcription Initiation Site Coincides with Induction of cdc2 Expression

1995 • 165 citations

Expression of the HsOrc1 Gene, a Human ORC1 Homolog, Is Regulated by Cell Proliferation via the E2F Transcription Factor

1996 • 145 citations

Transcription factor E2F is required for efficient expression of the hamster dihydrofolate reductase gene in vitro and in vivo.

1989 • 144 citations

The Ability of Purine and Thymine Derivatives and of Glycine to Support the Growth of Mammalian Cells in Culture

1959 • 136 citations

Functional analysis of GC element binding and transcription in the hamster dihydrofolate reductase gene promoter

1989 • 123 citations

Cell-cycle regulation of gene expression by transcriptional repression

1997 • 103 citations

Binding of the human E2F transcription factor to the retinoblastoma protein but not to cyclin A is abolished in HPV-16-immortalized cells.

1992 • 99 citations

Association of p107 with Sp1: Genetically Separable Regions of p107 Are Involved in Regulation of E2F- and Sp1-Dependent Transcription

1995 • 98 citations

A closer look at E2F

1992 • 95 citations

Regulation of dihydrofolate reductase gene expression in mouse fibroblasts during the transition from the resting to growing state

1978 • 89 citations

Cell-cycle regulation of human B-myb transcription

1995 • 72 citations

A Role for a Bent DNA Structure in E2F-Mediated Transcription Activation

1996 • 65 citations

Position-Dependent Transcriptional Regulation of the Murine Dihydrofolate Reductase Promoter by the E2F Transactivation Domain

1997 • 62 citations

Protein-DNA Interactions at the Major and Minor Promoters of the Divergently Transcribed dhfr and rep3 Genes during the Chinese Hamster Ovary Cell Cycle

1996 • 55 citations

The HIP1 binding site is required for growth regulation of the dihydrofolate reductase gene promoter.

1992 • 51 citations

Nucleotide sequence and nuclease hypersensitivity of the Chinese hamster dihydrofolate reductase gene promoter region

1986 • 42 citations

Promoter activity and distance constraints of one versus two Sp1 binding sites.

1991 • 24 citations

Stimulation of dihydrofolate reductase promoter activity by antimetabolic drugs.

1991 • 21 citations