An OspA-Based DNA Vaccine Protects Mice against Infection with Borrelia burgdorferi

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Direct Gene Transfer into Mouse Muscle in Vivo

1990 • 3,985 citations

Lyme Disease—a Tick-Borne Spirochetosis?

1982 • 2,831 citations

Heterologous Protection Against Influenza by Injection of DNA Encoding a Viral Protein

1993 • 2,330 citations

Enhanced gene delivery and mechanism studies with a novel series of cationic lipid formulations.

1994 • 1,306 citations

Protection of Mice Against the Lyme Disease Agent by Immunizing with Recombinant OspA

1990 • 480 citations

Lyme disease spirochetes and ixodid tick spirochetes share a common surface antigenic determinant defined by a monoclonal antibody

1983 • 443 citations

Gene Therapy by Intramuscular Injection of Plasmid DNA: Studies on Firefly Luciferase Gene Expression in Mice

1993 • 440 citations

Heterogeneity of Major Proteins in Lyme Disease Borreliae: A Molecular Analysis of North American and European Isolates

1985 • 365 citations

An Improved Plasmid DNA Expression Vector for Direct Injection into Skeletal Muscle

1996 • 336 citations

Molecular analysis of linear plasmid‐encoded major surface proteins, OspA and OspB, of the Lyme disease spirochaete Borrelia burgdorferi

1989 • 317 citations

Association of treatment-resistant chronic Lyme arthritis with HLA-DR4 and antibody reactivity to OspA and OspB of Borrelia burgdorferi

1993 • 294 citations

Immunogenic integral membrane proteins of Borrelia burgdorferi are lipoproteins

1990 • 279 citations

Monoclonal antibodies specific for the outer surface protein A (OspA) of Borrelia burgdorferi prevent Lyme borreliosis in severe combined immunodeficiency (scid) mice.

1990 • 269 citations

Conditions affecting direct gene transfer into rodent muscle in vivo.

1991 • 262 citations

Cancer Gene Therapy Using Plasmid DNA: Purification of DNA for Human Clinical Trials

1995 • 241 citations

The human tissue plasminogen activator gene.

1986 • 230 citations

Variable major proteins of Borrellia hermsii.

1982 • 223 citations

DNA immunization confers protection against lethal lymphocytic choriomeningitis virus infection

1995 • 185 citations

Role of attached lipid in immunogenicity of Borrelia burgdorferi OspA

1993 • 176 citations

Roles of OspA, OspB, and flagellin in protective immunity to Lyme borreliosis in laboratory mice

1992 • 173 citations

DNA Immunization against Experimental Genital Herpes Simplex Virus Infection

1996 • 157 citations

Antibody-resistant mutants of Borrelia burgdorferi: in vitro selection and characterization.

1992 • 155 citations

The urinary bladder, a consistent source of Borrelia burgdorferi in experimentally infected white-footed mice (Peromyscus leucopus)

1988 • 150 citations

Long-Term Anti-Nucleoprotein Cellular and Humoral Immunity Is Induced by Intramuscular Injection of Plasmid DNA Containing NP Gene

1993 • 150 citations

Recombination between genes encoding major outer surface proteins A and B of Borrelia burgdorferi

1992 • 138 citations

Protection of C3H/HeN mice from challenge with Borrelia burgdorferi through active immunization with OspA, OspB, or OspC, but not with OspD or the 83-kilodalton antigen

1994 • 135 citations

Clonal polymorphisms of outer membrane protein OspB of Borrelia burgdorferi

1989 • 132 citations

In Vitro Inhibition of Borrelia burgdorferi Growth by Antibodies

1993 • 132 citations

Passive immunization of hamsters against experimental infection with the Lyme disease spirochete

1986 • 123 citations

The T helper cell response in Lyme arthritis: differential recognition of Borrelia burgdorferi outer surface protein A in patients with treatment-resistant or treatment-responsive Lyme arthritis.

1994 • 123 citations

Towards a DNA vaccine against tuberculosis

1994 • 122 citations

Passive immunizing activity of sera from mice infected with Borrelia burgdorferi

1993 • 120 citations

Genetic vaccination against leishmaniasis

1994 • 116 citations

Organization of genes encoding two outer membrane proteins of the Lyme disease agent Borrelia burgdorferi within a single transcriptional unit

1986 • 116 citations

Borrelia burgdorferi mutant lacking Osp: biological and immunological characterization

1995 • 105 citations

Protection against malaria by immunization with a Plasmodium yoelii circumsporozoite protein nucleic acid vaccine

1994 • 94 citations

DNA vaccines: A novel approach to immunization

1995 • 92 citations

Safety and immunogenicity of a recombinant outer surface protein A Lyme vaccine.

1994 • 90 citations

Nucleic acid vaccines

1995 • 81 citations

Protection against Borrelia burgdorferi infection in SCID mice is conferred by presensitized spleen cells and partially by B but not T cells alone

1994 • 63 citations

Immunochemical analysis of Lyme disease spirochetes.

1984 • 62 citations

Long-term study of cell-mediated responses to Borrelia burgdorferi in the laboratory mouse

1993 • 50 citations

Protection AgainstMycoplasma pulmonisInfection by Genetic Vaccination

1995 • 49 citations

Nitric oxide production during murine Lyme disease: lack of involvement in host resistance or pathology

1995 • 48 citations

Safety and immunogenicity of a recombinant outer surface protein A Lyme vaccine

1994 • 30 citations

Identification of a highly cross-reactive outer surface protein B epitope among diverse geographic isolates of Borrelia spp. causing Lyme disease

1994 • 28 citations

A Flagella-less Mutant of Borrelia burgdorferi as a Live Attenuated Vaccine in the Murine Model of Lyme Disease

1996 • 23 citations

Single exposure of mice to Borrelia burgdorferi elicits immunoglobulin G antibodies characteristic of secondary immune response without production of interleukin-4 by immune T cells

1995 • 18 citations

Lyme borreliosis in transgenic mice tolerant to Borrelia burgdorferi OspA or B.

1995 • 17 citations