Identification of a highly cross-reactive outer surface protein B epitope among diverse geographic isolates of Borrelia spp. causing Lyme disease

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

A comprehensive set of sequence analysis programs for the VAX

1984 • 14,824 citations

[6] Use of T7 RNA polymerase to direct expression of cloned genes

1990 • 6,681 citations

Nonchromosomal Antibiotic Resistance in Bacteria: Genetic Transformation of Escherichia coli by R-Factor DNA

1972 • 2,842 citations

The Spirochetal Etiology of Lyme Disease

1983 • 1,590 citations

Isolation and cultivation of Lyme disease spirochetes.

1984 • 1,554 citations

Delineation of Borrelia burgdorferi Sensu Stricto, Borrelia garinii sp. nov., and Group VS461 Associated with Lyme Borreliosis

1992 • 882 citations

Borrelia burgdorferi sp. nov.: Etiologic Agent of Lyme Disease

1984 • 657 citations

The antigenic index: a novel algorithm for predicting antigenic determinants

1988 • 655 citations

Protection of Mice Against the Lyme Disease Agent by Immunizing with Recombinant OspA

1990 • 480 citations

Monoclonal Antibodies for Identification of Borrelia afzelii sp. nov. Associated with Late Cutaneous Manifestations of Lyme Borreliosis

1993 • 426 citations

Changes in infectivity and plasmid profile of the Lyme disease spirochete, Borrelia burgdorferi, as a result of in vitro cultivation

1988 • 390 citations

A Borrelia-specific monoclonal antibody binds to a flagellar epitope

1986 • 369 citations

Heterogeneity of Major Proteins in Lyme Disease Borreliae: A Molecular Analysis of North American and European Isolates

1985 • 365 citations

Cross-Reactivity in Serological Tests for Lyme Disease and Other Spirochetal Infections

1987 • 317 citations

Molecular analysis of linear plasmid‐encoded major surface proteins, OspA and OspB, of the Lyme disease spirochaete Borrelia burgdorferi

1989 • 317 citations

Degradation of Abnormal Proteins in Escherichia coli

1972 • 298 citations

Antigenic Variability of Borrelia burgdorferi

1988 • 298 citations

Variation in a major surface protein of Lyme disease spirochetes

1984 • 280 citations

Immunogenic integral membrane proteins of Borrelia burgdorferi are lipoproteins

1990 • 279 citations

Monoclonal antibodies specific for the outer surface protein A (OspA) of Borrelia burgdorferi prevent Lyme borreliosis in severe combined immunodeficiency (scid) mice.

1990 • 269 citations

Immunological and molecular polymorphisms of OspC, an immunodominant major outer surface protein of Borrelia burgdorferi

1993 • 253 citations

Genomic Fingerprinting by Arbitrarily Primed Polymerase Chain Reaction Resolves Borrelia burgdorferi into Three Distinct Phyletic Groups

1992 • 239 citations

Conspecificity of the Ticks Ixodes scapularis and I. dammini (Acari: Ixodidae)

1993 • 238 citations

Involvement of birds in the epidemiology of the Lyme disease agent Borrelia burgdorferi

1986 • 214 citations

The cryptic ospC gene of Borrelia burgdorferi B31 is located on a circular plasmid

1993 • 208 citations

Transcriptional analyses and mapping of the ospC gene in Lyme disease spirochetes

1993 • 177 citations

Roles of OspA, OspB, and flagellin in protective immunity to Lyme borreliosis in laboratory mice

1992 • 173 citations

Antibody-resistant mutants of Borrelia burgdorferi: in vitro selection and characterization.

1992 • 155 citations

Molecular analysis and expression of a Borrelia burgdorferi gene encoding a 22kDa protein (pC) in Escherichia coli

1992 • 153 citations

A Single Recombinant Plasmid Expressing Two Major Outer Surface Proteins of the Lyme Disease Spirochete

1985 • 149 citations

Characterization of Borrelia burgdorferi strains isolated from Ixodes pacificus ticks in California

1987 • 140 citations

Recombination between genes encoding major outer surface proteins A and B of Borrelia burgdorferi

1992 • 138 citations

Heterogeneity of outer membrane proteins in Borrelia burgdorferi: comparison of osp operons of three isolates of different geographic origins

1992 • 134 citations

Clonal polymorphisms of outer membrane protein OspB of Borrelia burgdorferi

1989 • 132 citations

Polymerase chain reaction analyses identify two distinct classes of Borrelia burgdorferi

1991 • 131 citations

Immune capture and detection of Borrelia burgdorferi antigens in urine, blood, or tissues from infected ticks, mice, dogs, and humans

1991 • 130 citations

Population genetic analysis of Borrelia burgdorferi isolates by multilocus enzyme electrophoresis

1992 • 119 citations

Selection of an escape variant of Borrelia burgdorferi by use of bactericidal monoclonal antibodies to OspB

1992 • 110 citations

Phenotypic and genotypic analysis of Borrelia burgdorferi isolates from various sources

1991 • 109 citations

Outer surface protein a (OspA) from the lyme disease spirochete, borrelia burgdorferi: High level expression and purification of a soluble recombinant form of OspA

1990 • 103 citations

Interaction of Lyme disease spirochetes with cultured eucaryotic cells

1989 • 101 citations

Polymorphisms of major surface proteins of Borrelia burgdorferi

1986 • 95 citations

An OspB mutant of Borrelia burgdorferi has reduced invasiveness in vitro and reduced infectivity in vivo

1993 • 94 citations

Specific adherence of Borrelia burgdorferi extracellular vesicles to human endothelial cells in culture

1993 • 84 citations

Variability of osp genes and gene products among species of Lyme disease spirochetes

1993 • 76 citations

Evasion of protective immunity by Borrelia burgdorferi by truncation of outer surface protein B.

1993 • 65 citations

A monoclonal antibody to OspA inhibits association of Borrelia burgdorferi with human endothelial cells

1993 • 64 citations

Species-specific identification of and distinction between Borrelia burgdorferi genomic groups by using 16S rRNA-directed oligonucleotide probes

1992 • 60 citations

A Method for Fast and Pure DNA Elution from Agarose Gels by Centrifugal Filtration

1985 • 54 citations

Regulation of expression of major outer surface proteins in Borrelia burgdorferi

1993 • 54 citations

Nucleotide sequence of the ospAB operon of a Borrelia burgdorferi strain expressing OspA but not OspB

1992 • 39 citations

Molecular Characterization of Borrelia burgdorferi Isolated from Ixodes ricinus in Northern Sweden

1992 • 33 citations

Susceptibility of Laboratory Rats to Isolates of Borrelia burgdorferi from Different Geographic Areas

1990 • 23 citations

Sequence of the complete osp operon encoding two major outer membrane proteins of a European Borrelia burgdorferi isolate (B29)

1992 • 6 citations