Gene Therapy by Intramuscular Injection of Plasmid DNA: Studies on Firefly Luciferase Gene Expression in Mice

Direct Gene Transfer into Mouse Muscle in Vivo

1990 • 3,985 citations

Firefly luciferase gene: structure and expression in mammalian cells.

1987 • 3,088 citations

Heterologous Protection Against Influenza by Injection of DNA Encoding a Viral Protein

1993 • 2,330 citations

Identification of a receptor for the morphogen retinoic acid

1987 • 2,007 citations

CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements

1987 • 1,792 citations

SRα Promoter: an Efficient and Versatile Mammalian cDNA Expression System Composed of the Simian Virus 40 Early Promoter and the R-U5 Segment of Human T-Cell Leukemia Virus Type 1 Long Terminal Repeat

1988 • 1,351 citations

Long-term persistence of plasmid DNA and foreign gone expression in mouse muscle

1992 • 743 citations

SR alpha promoter: an efficient and versatile mammalian cDNA expression system composed of the simian virus 40 early promoter and the R-U5 segment of human T-cell leukemia virus type 1 long terminal repeat.

1988 • 638 citations

Removal of endotoxin from protein solutions by phase separation using triton X-114

1990 • 584 citations

Human dystrophin expression in mdx mice after intramuscular injection of DNA constructs

1991 • 486 citations

Expression of recombinant genes in myocardium in vivo after direct injection of DNA.

1990 • 364 citations

Plasmid DNA Is Superior to Viral Vectors for Direct Gene Transfer into Adult Mouse Skeletal Muscle

1993 • 314 citations

Gene therapy via primary myoblasts: long-term expression of factor IX protein following transplantation in vivo.

1992 • 313 citations

Effect of intron A from human cytomegalovirus (Towne) immediate-early gene on heterologous expression in mammalian cells

1991 • 297 citations

Long-term in vivo expression of retrovirus-mediated gene transfer in mouse fibroblast implants.

1991 • 288 citations

Direct Gene Transfer into Nonhuman Primate Myofibers In Vivo

1992 • 284 citations

Conditions affecting direct gene transfer into rodent muscle in vivo.

1991 • 262 citations

The muscle creatine kinase gene is regulated by multiple upstream elements, including a muscle-specific enhancer.

1988 • 236 citations

The cytomegalovirus enhancer: a pan-active control element in transgenic mice.

1990 • 211 citations

Direct gene transfer and expression into rat heart in vivo.

1991 • 208 citations

Hormonal modulation of a gene injected into rat heart in vivo.

1991 • 180 citations

Direct gene transfer in skeletal muscle: plasmid DNA-based immunization against the hepatitis B virus surface antigen

1994 • 176 citations

In VivoGene Transfer into Rabbit Thyroid Follicular Cells by Direct DNA Injection

1994 • 141 citations

Behavior of genes directly injected into the rat heart in vivo.

1992 • 136 citations

Immunization with DNA

1994 • 132 citations

Strong expression of foreign genes following direct injection into fish muscle

1991 • 128 citations

Non-viral gene therapy

1994 • 118 citations

Circulating human or canine factor IX from retrovirally transduced primary myoblasts and established myoblast cell lines grafted into murine skeletal muscle

1992 • 61 citations

Multicompartment, Numerical Model of Cellular Events in the Pharmacokinetics of Gene Therapies

1994 • 59 citations

Immunization with plasmid DNA using a pneumatic gun

1994 • 57 citations

Protein expression in vivo by injection of polynucleotides

1994 • 30 citations

Gene transfer into cardiac myocytes in vivo

1991 • 30 citations

Twin Quasars Found

1990 • 23 citations