A Flagella-less Mutant of Borrelia burgdorferi as a Live Attenuated Vaccine in the Murine Model of Lyme Disease

A SIMPLE METHOD OF ESTIMATING FIFTY PER CENT ENDPOINTS12

1938 • 19,183 citations

The Spirochetal Etiology of Lyme Disease

1983 • 1,590 citations

New use of BCG for recombinant vaccines

1991 • 1,463 citations

The Biological and Social Phenomenon of Lyme Disease

1993 • 624 citations

Protection of Mice Against the Lyme Disease Agent by Immunizing with Recombinant OspA

1990 • 480 citations

Lyme Borreliosis in Selected Strains and Ages of Laboratory Mice

1990 • 446 citations

An OspA serotyping system for Borrelia burgdorferi based on reactivity with monoclonal antibodies and OspA sequence analysis

1993 • 344 citations

Comparison of Immunoblotting and Indirect Enzyme-Linked Immunosorbent Assay Using Different Antigen Preparations for Diagnosing Early Lyme Disease

1988 • 294 citations

Monoclonal antibodies specific for the outer surface protein A (OspA) of Borrelia burgdorferi prevent Lyme borreliosis in severe combined immunodeficiency (scid) mice.

1990 • 269 citations

Protective immunity elicited by recombinant bacille Calmette-Guerin (BCG) expressing outer surface protein A (OspA) lipoprotein: a candidate Lyme disease vaccine.

1993 • 269 citations

Antibodies of patients with Lyme disease to components of the Ixodes dammini spirochete.

1983 • 191 citations

Recombinant Outer Surface Protein A from Borrelia burgdorferi Induces Antibodies Protective against Spirochetal Infection in Mice

1991 • 185 citations

Role of attached lipid in immunogenicity of Borrelia burgdorferi OspA

1993 • 176 citations

Roles of OspA, OspB, and flagellin in protective immunity to Lyme borreliosis in laboratory mice

1992 • 173 citations

Antibody-resistant mutants of Borrelia burgdorferi: in vitro selection and characterization.

1992 • 155 citations

The urinary bladder, a consistent source of Borrelia burgdorferi in experimentally infected white-footed mice (Peromyscus leucopus)

1988 • 150 citations

Recombination between genes encoding major outer surface proteins A and B of Borrelia burgdorferi

1992 • 138 citations

Active immunization with pC protein ofBorrelia burgdorferi protects gerbils againstB. burgdorferi infection

1992 • 136 citations

Heterogeneity of outer membrane proteins in Borrelia burgdorferi: comparison of osp operons of three isolates of different geographic origins

1992 • 134 citations

In Vitro Inhibition of Borrelia burgdorferi Growth by Antibodies

1993 • 132 citations

Clonal polymorphisms of outer membrane protein OspB of Borrelia burgdorferi

1989 • 132 citations

Reactivity of human Lyme borreliosis sera with a 39-kilodalton antigen specific to Borrelia burgdorferi

1990 • 132 citations

Variability of a bacterial surface protein and disease expression in a possible mouse model of systemic Lyme borreliosis.

1994 • 125 citations

Molecular mimicry and lyme borreliosis: A shared antigenic determinant between Borrelia burgdorferi and human tissue

1989 • 124 citations

Passive immunization of hamsters against experimental infection with the Lyme disease spirochete

1986 • 123 citations

Serodiagnosis of erythema migrans and acrodermatitis chronica atrophicans by the Borrelia burgdorferi flagellum enzyme-linked immunosorbent assay

1989 • 121 citations

Passive immunizing activity of sera from mice infected with Borrelia burgdorferi

1993 • 120 citations

A flagella-less mutant of Borrelia burgdorferi. Structural, molecular, and in vitro functional characterization.

1991 • 113 citations

Borrelia burgdorferi mutant lacking Osp: biological and immunological characterization

1995 • 105 citations

Characterization of the Borreliacidal Antibody Response to Borrelia burgdorferi in Humans: A Serodiagnostic Test

1993 • 91 citations

Active immunization of hamsters against experimental infection with Borrelia burgdorferi

1986 • 91 citations

Safety and immunogenicity of a recombinant outer surface protein A Lyme vaccine.

1994 • 90 citations

Sera from Patients with Chronic Lyme Disease Protect Mice from Lyme Borreliosis

1994 • 83 citations

Immunoblot analysis of immunoglobulin G response to the Lyme disease agent (Borrelia burgdorferi) in experimentally and naturally exposed dogs

1988 • 79 citations

Characterization of the protective antibody response to Borrelia burgdorferi in experimentally infected LSH hamsters

1991 • 72 citations

Immunogenicity and efficacy study of a commercial Borrelia burgdorferi bacterin

1992 • 72 citations

Development of destructive arthritis in vaccinated hamsters challenged with Borrelia burgdorferi

1994 • 67 citations

Passive immunization prevents induction of Lyme arthritis in LSH hamsters

1990 • 64 citations

Distinct patterns of protective antibodies are generated against Borrelia burgdorferi in mice experimentally inoculated with high and low doses of antigen

1993 • 58 citations

Protective immunity is induced by a Borrelia burgdorferi mutant that lacks OspA and OspB

1993 • 55 citations

Antigenic stability of Borrelia burgdorferi during chronic infections of immunocompetent mice

1993 • 52 citations

Characterization of a tick isolate of Borrelia burgdorferi that possesses a major low-molecular-weight surface protein

1990 • 47 citations

A live avirulent mutant Legionella pneumophila vaccine induces protective immunity against lethal aerosol challenge.

1989 • 46 citations

Introduction of Francisella tularensis at skin sites induces resistance to infection and generation of protective immunity

1992 • 46 citations

Performance of a Borrelia burgdorferi bacterin in borreliosis-endemic areas.

1993 • 42 citations

Serologic response to the Borrelia burgdorferi flagellin demonstrates an epitope common to a neuroblastoma cell line.

1993 • 41 citations

Immunity in experimental syphilis. V. The immunogenicity of Treponema pallidum attenuated by gamma-irradiation.

1967 • 41 citations

Susceptibility of Laboratory Rats to Isolates of Borrelia burgdorferi from Different Geographic Areas

1990 • 23 citations