The T helper cell response in Lyme arthritis: differential recognition of Borrelia burgdorferi outer surface protein A in patients with treatment-resistant or treatment-responsive Lyme arthritis.

MHC-Restricted Cytotoxic T Cells: Studies on the Biological Role of Polymorphic Major Transplantation Antigens Determining T-Cell Restriction-Specificity, Function, and Responsiveness

1979 • 1,969 citations

Ablation of “tolerance” and induction of diabetes by virus infection in viral antigen transgenic mice

1991 • 1,187 citations

Lyme Disease

1989 • 1,169 citations

Molecular mimicry and autoimmune disease

1987 • 943 citations

Signals and signs for lymphocyte responses

1994 • 868 citations

The Clinical Evolution of Lyme Arthritis

1987 • 773 citations

Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: Role of anti-self (virus) immune response

1991 • 766 citations

Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity

1993 • 688 citations

The Biological and Social Phenomenon of Lyme Disease

1993 • 624 citations

Detection of Borrelia burgdorferi DNA by Polymerase Chain Reaction in Synovial Fluid from Patients with Lyme Arthritis

1994 • 591 citations

Yersinia Antigens in Synovial-Fluid Cells from Patients with Reactive Arthritis

1989 • 482 citations

Protection of Mice Against the Lyme Disease Agent by Immunizing with Recombinant OspA

1990 • 480 citations

Lyme disease spirochetes and ixodid tick spirochetes share a common surface antigenic determinant defined by a monoclonal antibody

1983 • 443 citations

Antigens of Borrelia burgdorferi recognized during Lyme disease. Appearance of a new immunoglobulin M response and expansion of the immunoglobulin G response late in the illness.

1986 • 374 citations

Association of Chronic Lyme Arthritis with HLA-DR4 and HLA-DR2 Alleles

1990 • 359 citations

TREATMENT OF LATE LYME BORRELIOSIS—RANDOMISED COMPARISON OF CEFTRIAXONE AND PENICILLIN

1988 • 322 citations

Distinct types of lung disease caused by functional subsets of antiviral T cells.

1994 • 318 citations

Molecular analysis of linear plasmid‐encoded major surface proteins, OspA and OspB, of the Lyme disease spirochaete Borrelia burgdorferi

1989 • 317 citations

Association of treatment-resistant chronic Lyme arthritis with HLA-DR4 and antibody reactivity to OspA and OspB of Borrelia burgdorferi

1993 • 294 citations

Variation in a major surface protein of Lyme disease spirochetes

1984 • 280 citations

Borrelia burgdorferi activates a T helper type 1-like T cell subset in Lyme arthritis.

1991 • 277 citations

Protective immunity elicited by recombinant bacille Calmette-Guerin (BCG) expressing outer surface protein A (OspA) lipoprotein: a candidate Lyme disease vaccine.

1993 • 269 citations

Monoclonal antibodies specific for the outer surface protein A (OspA) of Borrelia burgdorferi prevent Lyme borreliosis in severe combined immunodeficiency (scid) mice.

1990 • 269 citations

Treatment of lyme arthritis

1994 • 268 citations

Chronic Lyme Arthritis

1979 • 258 citations

Immunological and molecular polymorphisms of OspC, an immunodominant major outer surface protein of Borrelia burgdorferi

1993 • 253 citations

Elimination of Borrelia burgdorferi from vector ticks feeding on OspA-immunized mice.

1992 • 243 citations

Spirochetal antigens and lymphoid cell surface markers in lyme synovitis

1988 • 220 citations

Lyme arthritis. Spirochetes found in synovial microangiopathic lesions.

1985 • 217 citations

SUCCESSFUL PARENTERAL PENICILLIN THERAPY OF ESTABLISHED LYME ARTHRITIS

1985 • 210 citations

Inhibition of human immunodeficiency virus gene amplification by heparin

1991 • 196 citations

The long-term maintenance of cytotoxic T cell memory does not require persistence of antigen.

1994 • 190 citations

Recombinant Outer Surface Protein A from Borrelia burgdorferi Induces Antibodies Protective against Spirochetal Infection in Mice

1991 • 185 citations

Roles of OspA, OspB, and flagellin in protective immunity to Lyme borreliosis in laboratory mice

1992 • 173 citations

Borrelia burgdorferi in Joint Fluid in Chronic Lyme Arthritis

1986 • 170 citations

Lipoproteins of Borrelia burgdorferi and Treponema pallidum activate cachectin/tumor necrosis factor synthesis. Analysis using a CAT reporter construct.

1991 • 158 citations

Heritable susceptibility to severe Borrelia burgdorferi-induced arthritis is dominant and is associated with persistence of large numbers of spirochetes in tissues

1994 • 158 citations

Interleukin-2 can prevent and reverse antigen-induced unresponsiveness in cloned human T lymphocytes.

1988 • 146 citations

Humoral immune response to outer surface protein C of Borrelia burgdorferi in Lyme disease: role of the immunoglobulin M response in the serodiagnosis of early infection

1994 • 133 citations

Reactivity of human Lyme borreliosis sera with a 39-kilodalton antigen specific to Borrelia burgdorferi

1990 • 132 citations

Class II-restricted T cell responses in Theiler's murine encephalomyelitis virus-induced demyelinating disease. VI. Potentiation of demyelination with and characterization of an immunopathologic CD4+ T cell line specific for an immunodominant VP2 epitope.

1994 • 128 citations

Target Imbalance: Disparity of Borrelia burgdorferi Genetic Material in Synovial Fluid from Lyme Arthritis Patients

1994 • 119 citations

Lyme disease spirochetes induce human and murine interleukin 1 production.

1985 • 111 citations

The Persistence of Spirochetal Nucleic Acids in Active Lyme Arthritis

1994 • 108 citations

Proliferative responses of mononuclear cells in Lyme disease. Reactivity to Borrelia burgdorferi antigens is greater in joint fluid than in blood

1986 • 105 citations

Yersinia enterocolitica activates a T helper type 1-like T cell subset in reactive arthritis.

1992 • 79 citations

Immunopathologic mechanisms in lower respiratory tract disease of infants due to respiratory syncytial virus.

1980 • 74 citations

Failure of tetracycline therapy in early lyme disease

1987 • 74 citations

Minimum structural requirements for peptide presentation by major histocompatibility complex class II molecules: implications in induction of autoimmunity.

1994 • 70 citations

Cellular immune reactivity to recombinant OspA and flagellin from Borrelia burgdorferi in patients with Lyme borreliosis. Complexity of humoral and cellular immune responses.

1992 • 69 citations

Pertussis toxin prevents the induction of peripheral T cell anergy and enhances the T cell response to an encephalitogenic peptide of myelin basic protein.

1991 • 65 citations

Analysis of cytokine profiles in synovial T cell clones from chlamydial reactive arthritis patients: predominance of the Th1 subset

1993 • 57 citations

In vivo administration of interleukin‐2 turns on anergic self‐reactive T cells and leads to autoimmune disease

1992 • 44 citations

Protection against antigenically variable Borrelia burgdorferi conferred by recombinant vaccines.

1993 • 43 citations

Epitopes on the outer surface protein A of Borrelia burgdorferi recognized by antibodies and T cells of patients with Lyme disease.

1992 • 35 citations

Ablation of ‘tolerance’ and induction of diabetes by virus infection in viral antigen transgenic mice

1991 • 34 citations

Preferential usage of T cell antigen receptor V region gene segment V beta 5.1 by Borrelia burgdorferi antigen-reactive T cell clones isolated from a patient with Lyme disease.

1993 • 33 citations

The regulatory effects of cytokines on the induction of a peripheral immunologic tolerance in mice.

1990 • 28 citations

Successful Parenteral Penicillin Therapy of Established Lyme Arthritis

1985 • 25 citations

Frequencies of Borrelia burgdorferi-reactive T lymphocytes in Lyme arthritis

1989 • 24 citations

Characterization of an immunoreactive 93-kDa core protein of Borrelia burgdorferi with a human IgG monoclonal antibody.

1991 • 21 citations

Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: role of anti-self (virus) immune response

1991 • 6 citations

Borrelia burgdorferi in joint fluid in chronic Lyme arthritis

1986 • 6 citations

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