The Ran/TC4 GTPase-binding domain: identification by expression cloning and characterization of a conserved sequence motif.

Basic local alignment search tool

1990 • 87,358 citations

2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans

1994 • 1,472 citations

The GTP-binding protein Ran/TC4 is required for protein import into the nucleus

1993 • 760 citations

Inhibition of nuclear protein import by nonhydrolyzable analogues of GTP and identification of the small GTPase Ran/TC4 as an essential transport factor [published erratum appears in J Cell Biol 1994 Jan;124(1-2):217]

1993 • 544 citations

RanGAP1 induces GTPase activity of nuclear Ras-related Ran.

1994 • 526 citations

A nuclear pore complex protein that contains zinc finger motifs, binds DNA, and faces the nucleoplasm

1993 • 308 citations

Characterization of Four Novel ras-Like Genes Expressed in a Human Teratocarcinoma Cell Line

1990 • 285 citations

Characterization of proteins that interact with the cell-cycle regulatory protein Ran/TC4

1993 • 261 citations

The human CAN protein, a putative oncogene productassociated with myeloid leukemogenesis, is a nuclear pore complex protein thatfaces the cytoplasm.

1994 • 238 citations

Premature initiation of mitosis in yeast lacking RCC1 or an interacting GTPase

1991 • 231 citations

Ran/TC4: a small nuclear GTP-binding protein that regulates DNA synthesis.

1993 • 195 citations

Loss of RCC1, a nuclear DNA-binding protein, uncouples the completion of DNA replication from the activation of cdc2 protein kinase and mitosis.

1991 • 195 citations

Regulation of RNA processing and transport by a nuclear guanine nucleotide release protein and members of the Ras superfamily.

1993 • 183 citations

The GTP-bound form of the yeast Ran/TC4 homologue blocks nuclear protein import and appearance of poly(A)+ RNA in the cytoplasm.

1995 • 170 citations

Nuclear PRP20 protein is required for mRNA export.

1993 • 148 citations

GSP1 and GSP2, genetic suppressors of the prp20-1 mutant in Saccharomyces cerevisiae: GTP-binding proteins involved in the maintenance of nuclear organization.

1993 • 145 citations

Defects in mRNA 3'-end formation, transcription initiation, and mRNA transport associated with the yeast mutation prp20: possible coupling of mRNA processing and chromatin structure.

1992 • 142 citations

Evidence for a dual role for TC4 protein in regulating nuclear structure and cell cycle progression.

1994 • 139 citations

A fission yeast RCC1-related protein is required for the mitosis to interphase transition.

1994 • 134 citations

A family of proteins that stabilize the Ran/TC4 GTPase in its GTP-bound conformation

1994 • 116 citations

RCC1, a Regulator of Mitosis, Is Essential for DNA Replication

1992 • 106 citations

Characterization of a guanine nucleotide-releasing factor and a GTPase-activating protein that are specific for the ras-related protein p25rab3A.

1992 • 88 citations

Muscarinic receptors transform NIH 3T3 cells through a Ras-dependent signalling pathway inhibited by the Ras-GTPase-activating protein SH3 domain.

1994 • 88 citations

Effects of mutant Ran/TC4 proteins on cell cycle progression.

1994 • 77 citations

Characterization of the opposite-strand genes from the mouse bidirectionally transcribed HTF9 locus

1991 • 42 citations

GSP1 and GSP2, Genetic Suppressors of the prp20-1 Mutant in Saccharomyces cerevisiae: GTP-Binding Proteins Involved in the Maintenance of Nuclear Organization

1993 • 33 citations

Muscarinic Receptors Transform NIH 3T3 Cells through a Ras-Dependent Signalling Pathway Inhibited by the Ras-GTPase-Activating Protein SH3 Domain

1994 • 26 citations

Effects of Mutant Ran/TC4 Proteins on Cell Cycle Progression

1994 • 20 citations