Interactions of nitric oxide with hemoproteins: roles of nitric oxide in mitochondria

NITRIC OXIDE AND MACROPHAGE FUNCTION

1997 • 4,106 citations

Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells.

1989 • 1,747 citations

S-nitrosohaemoglobin: a dynamic activity of blood involved in vascular control

1996 • 1,604 citations

Superoxide generation by endothelial nitric oxide synthase: The influence of cofactors

1998 • 1,475 citations

Nitric oxide activates guanylate cyclase and increases guanosine 3′:5′-cyclic monophosphate levels in various tissue preparations

1977 • 1,422 citations

Peroxynitrite, a cloaked oxidant formed by nitric oxide and superoxide

1992 • 1,319 citations

Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide

1994 • 1,214 citations

Blood Flow Regulation by S -Nitrosohemoglobin in the Physiological Oxygen Gradient

1997 • 1,050 citations

Bright and dark sides of nitric oxide in ischemic brain injury

1997 • 1,043 citations

Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase

1994 • 1,026 citations

L-arginine is required for expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells.

1987 • 958 citations

Persistent inhibition of cell respiration by nitric oxide: Crucial role ofS-nitrosylation of mitochondrial complex I and protective action of glutathione

1998 • 825 citations

Nitric oxide synthase generates superoxide and nitric oxide in arginine-depleted cells leading to peroxynitrite-mediated cellular injury.

1996 • 730 citations

Soluble Guanylate Cyclase from Bovine Lung: Activation with Nitric Oxide and Carbon Monoxide and Spectral Characterization of the Ferrous and Ferric States

1994 • 641 citations

Formation and Properties of Peroxynitrite as Studied by Laser Flash Photolysis, High-Pressure Stopped-Flow Technique, and Pulse Radiolysis

1997 • 620 citations

Mechanism of NO-Induced Oxidation of Myoglobin and Hemoglobin

1996 • 609 citations

Aconitase is readily inactivated by peroxynitrite, but not by its precursor, nitric oxide.

1994 • 596 citations

Differentiation of murine macrophages to express nonspecific cytotoxicity for tumor cells results in L-arginine-dependent inhibition of mitochondrial iron-sulfur enzymes in the macrophage effector cells.

1988 • 592 citations

Accelerated reaction of nitric oxide with O ₂ within the hydrophobic interior of biological membranes

1998 • 590 citations

Superoxide and peroxynitrite inactivate aconitases, but nitric oxide does not.

1994 • 585 citations

Reactions between nitric oxide and haemoglobin under physiological conditions

1998 • 577 citations

Nitric oxide synthase activity in mitochondria

1997 • 576 citations

Production of Nitric Oxide by Mitochondria

1998 • 573 citations

Nitric oxide regulates mitochondrial respiration and cell functions by inhibiting cytochrome oxidase

1995 • 540 citations

Nitric Oxide‐Mediated Mitochondrial Damage in the Brain: Mechanisms and Implications for Neurodegenerative Diseases

1997 • 525 citations

EPR demonstration of iron-nitrosyl complex formation by cytotoxic activated macrophages.

1990 • 512 citations

Diffusion-limited Reaction of Free Nitric Oxide with Erythrocytes

1998 • 506 citations

Murine cytotoxic activated macrophages inhibit aconitase in tumor cells. Inhibition involves the iron-sulfur prosthetic group and is reversible.

1986 • 421 citations

Diffusion of peroxynitrite across erythrocyte membranes

1998 • 399 citations

Effect of exogenous and endogenous nitric oxide on mitochondrial respiration of rat hepatocytes

1991 • 395 citations

Inducible Nitric-oxide Synthase Generates Superoxide from the Reductase Domain

1998 • 389 citations

Endothelial-Type Nitric Oxide Synthase (ec-NOS) in Skeletal Muscle Fibers: Mitochondrial Relationships

1995 • 379 citations

EPR characterization of molecular targets for NO in mammalian cells and organelles

1993 • 373 citations

Modulation of Superoxide-dependent Oxidation and Hydroxylation Reactions by Nitric Oxide

1996 • 355 citations

Purification and Characterization of a Nitric-oxide Synthase from Rat Liver Mitochondria

1998 • 329 citations

Nitric Oxide Potently and Reversibly Deenergizes Mitochondria at Low Oxygen Tension

1994 • 324 citations

Nitric oxide and peroxynitrite exert distinct effects on mitochondrial respiration which are differentially blocked by glutathione or glucose

1996 • 320 citations

Metabolic Fate of Peroxynitrite in Aqueous Solution

1997 • 318 citations

Nitric oxide synthesis in the lung. Regulation by oxygen through a kinetic mechanism.

1998 • 311 citations

Spectral and Kinetic Studies on the Activation of Soluble Guanylate Cyclase by Nitric Oxide

1996 • 308 citations

Carbon Dioxide Enhancement of Peroxynitrite-Mediated Protein Tyrosine Nitration

1996 • 302 citations

Peroxynitrite rapidly permeates phospholipid membranes

1997 • 299 citations

Reactions between Nitric Oxide, Superoxide, and Peroxynitrite: Footprints of Peroxynitrite in Vivo

1995 • 295 citations

Generation of EPR-detectable nitrosyl-iron complexes in tumor target cells cocultured with activated macrophages

1991 • 280 citations

Acceleration of Peroxynitrite Oxidations by Carbon Dioxide

1996 • 277 citations

An EPR Investigation of the Products of the Reaction of Cytosolic and Mitochondrial Aconitases with Nitric Oxide

1997 • 256 citations

Effective diffusion distance of nitric oxide in the microcirculation

1998 • 248 citations

Mitochondrial Nitric Oxide Synthase: A Ubiquitous Regulator of Oxidative Phosphorylation?

1996 • 244 citations

Rapid reduction of nitric oxide by mitochondria, and reversible inhibition of mitochondrial respiration by nitric oxide

1996 • 243 citations

Increased expression of an inducible isoform of nitric oxide synthase and the formation of peroxynitrite in colonic mucosa of patients with active ulcerative colitis

1998 • 241 citations

Kinetics of Nitric Oxide Autoxidation in Aqueous Solution in the Absence and Presence of Various Reductants. The Nature of the Oxidizing Intermediates

1995 • 239 citations

Nitric Oxide Sensitivity of the Aconitases

1997 • 234 citations

Reactions of nitric oxide with cytochrome c oxidase

1980 • 232 citations

Functional implications of nitric oxide produced by mitochondria in mitochondrial metabolism

1998 • 221 citations

Inhibition of cytochrome c oxidase in turnover by nitric oxide: mechanism and implications for control of respiration

1995 • 207 citations

Nitric oxide produced by activated astrocytes rapidly and reversibly inhibits cellular respiration

1995 • 204 citations

Reactions of nitric oxide with mitochondrial cytochrome c: a novel mechanism for the formation of nitroxyl anion and peroxynitrite

1998 • 203 citations

Nitric oxide, a biological effector

1991 • 203 citations

Mitochondrial Creatine Kinase Is a Prime Target of Peroxynitrite-induced Modification and Inactivation

1998 • 196 citations

Role of nitric oxide in mediation of macrophage cytotoxicity and apoptosis.

1998 • 180 citations

Carbon Dioxide: Physiological Catalyst for Peroxynitrite-Mediated Cellular Damage or Cellular Protectant?

1996 • 176 citations

Upregulation of protein-tyrosine nitration in the anterior horn cells of amyotrophic lateral sclerosis

1997 • 169 citations

Kinetics of Nitric Oxide Dissociation from Five- and Six-Coordinate Nitrosyl Hemes and Heme Proteins, Including Soluble Guanylate Cyclase

1997 • 169 citations

The Physiological and Pathological Chemistry of Nitric Oxide

1996 • 168 citations

Binding of Nitric Oxide and Carbon Monoxide to Soluble Guanylate Cyclase As Observed with Resonance Raman Spectroscopy

1996 • 156 citations

Electron Paramagnetic Resonance Spectral Evidence for the Formation of a Pentacoordinate Nitrosyl-Heme Complex on Soluble Guanylate Cyclase

1995 • 153 citations

Increased nitric oxide production accompanied by the up‐regulation of inducible nitric oxide synthase in vascular endothelium from patients with systemic lupus erythematosus

1997 • 153 citations

Inhibition of target cell mitochondrial electron transfer by tumor necrosis factor

1989 • 148 citations

On the Mechanism of Inhibition of Cytochrome c Oxidase by Nitric Oxide

1996 • 142 citations

Kinetics and Mechanism of Tetrahydrobiopterin-induced Oxidation of Nitric Oxide

1995 • 142 citations

Direct measurement of nitric oxide generation from nitric oxide synthase

1997 • 140 citations

Direct and indirect oxidations by peroxynitrite, neither involving the hydroxyl radical

1996 • 140 citations

Electron Paramagnetic Resonance and Oxygen Binding Studies of α-Nitrosyl Hemoglobin

1998 • 140 citations

Reactions of Nitric Oxide with Metalloproteins

1996 • 136 citations

The role of the reactions of ·NO with superoxide and oxygen in biological systems: A kinetic approach

1995 • 134 citations

Detection of nitric oxide and nitric oxide synthases in psoriasis

1998 • 126 citations

Kinetics of the inhibition of mitochondrial respiration by NO

1997 • 125 citations

Hydrogen Peroxide Formation by Reaction of Peroxynitrite with HEPES and Related Tertiary Amines

1998 • 123 citations

Studies of the primary oxygen intermediate in the reaction of fully reduced cytochrome oxidase.

1991 • 122 citations

Kinetics of N-Nitrosation in Oxygenated Nitric Oxide Solutions at Physiological pH: Role of Nitrous Anhydride and Effects of Phosphate and Chloride

1995 • 121 citations

Inactivation of Dehydratase [4Fe-4S] Clusters and Disruption of Iron Homeostasis upon Cell Exposure to Peroxynitrite

1997 • 117 citations

Structure of cytochrome a3-Cua3 couple in cytochrome c oxidase as revealed by nitric oxide binding studies.

1979 • 112 citations

Localization of the Heme Binding Region in Soluble Guanylate Cyclase^†

1997 • 111 citations

Nitric oxide inhibition of cytochrome oxidase and mitochondrial respiration: Implications for inflammatory, neurodegenerative and ischaemic pathologies

1997 • 109 citations

Nitric oxide ejects electrons from the binuclear centre of cytochrome c oxidase by reacting with oxidised copper: a general mechanism for the interaction of copper proteins with nitric oxide?

1997 • 104 citations

Free Radical Formation in the Peroxynitrous Acid (ONOOH)/Peroxynitrite (ONOO^-) System

1998 • 103 citations

Dissociation of Nitric Oxide from Soluble Guanylate Cyclase

1997 • 95 citations

Multiple Controls in Inflammation

1998 • 93 citations

Heme Stoichiometry of Heterodimeric Soluble Guanylate Cyclase

1995 • 90 citations

Resonance Raman Spectroscopy of Soluble Guanylyl Cyclase Reveals Displacement of Distal and Proximal Heme Ligands by NO

1994 • 89 citations

How does NO activate hemeproteins?

1994 • 85 citations

The Effects of Nitric Oxide on Electron Transport Complexes

1996 • 85 citations

Cytochrome c Oxidase Catalysis of the Reduction of Nitric Oxide to Nitrous Oxide

1995 • 72 citations

Effects of GTP on Bound Nitric Oxide of Soluble Guanylate Cyclase Probed by Resonance Raman Spectroscopy

1997 • 72 citations

Nitric oxide function in atherosclerosis

1997 • 71 citations

Cytochrome c Oxidase Does Not Catalyze the Anaerobic Reduction of NO

1998 • 68 citations

Properties and Structure of the Compounds Formed between Cytochrome c and Nitric Oxide.

1960 • 65 citations

Fuel oxidation in skeletal muscle is increased by nitric oxide/cGMP – evidence for involvement of cGMP‐dependent protein kinase

1998 • 62 citations

Detection of Nitrosyl Complexes in Human Substantia Nigra, in Relation to Parkinson's Disease

1996 • 59 citations

Physiological Role of Nitric Oxide as an Enhancer of Oxygen Transfer from Erythrocytes to Tissues

1996 • 58 citations

Structural Changes in the Heme Proximal Pocket Induced by Nitric Oxide Binding to Soluble Guanylate Cyclase

1998 • 57 citations

Spectral and Ligand-Binding Properties of an Unusual Hemoprotein, the Ferric Form of Soluble Guanylate Cyclase

1996 • 57 citations

The Reaction of S-Nitrosoglutathione with Superoxide

1998 • 57 citations

Insensitivity of the Rate of Decomposition of Peroxynitrite to Changes in Viscosity; Evidence against Free Radical Formation

1996 • 57 citations

Thiols Protect the Inhibition of Myocardial Aconitase by Peroxynitrite

1998 • 53 citations

Infrared Characterization of Nitric Oxide Bonding to Bovine Heart Cytochrome c Oxidase and Myoglobin

1994 • 51 citations

Nitrosyl hemoglobin in blood of normoxic and hypoxic sheep during nitric oxide inhalation

1998 • 51 citations

Nitric oxide binding to ferrous native horse heart cytochrome c and to its carboxymethylated derivative: A spectroscopic and thermodynamic Study

1994 • 49 citations

Electron paramagnetic resonance of nitric oxide cytochrome c

1969 • 43 citations

Differential Sensitivity of the Tyrosyl Radical of Mouse Ribonucleotide Reductase to Nitric Oxide and Peroxynitrite

1998 • 41 citations

Basic Chemistry of Nitric Oxide and Related Nitrogen Oxides

1997 • 38 citations

Nitrosyl cytochrome c oxidase. Formation and properties of mixed valence enzyme.

1988 • 36 citations

Nitric oxide-triggered heme-mediated hydrolysis: a possible model for biological reactions of NO

1993 • 33 citations

Reaction of Peroxynitrite with HEPES or MOPS Results in the Formation of Nitric Oxide Donors

1998 • 32 citations

Nitric oxide, a physiological modulator of mitochondrial function.

1996 • 31 citations

The Interactions between Nitric Oxide and Brain Nerve Terminals as Studied by Electron Paramagnetic Resonance

1995 • 27 citations

Nitrosylation of Blood Hemoglobin and Renal Nonheme Proteins in Autoimmune MRL-lpr/lpr Mice

1998 • 27 citations

EPR Characterization of Nitric Oxide Binding to Hemoglobin

1997 • 12 citations

Utilization of Nitric Oxide as a Paramagnetic Probe of the Molecular Oxygen Binding Site of Metalloenzymes

1997 • 5 citations

Effects of Nitric Oxide on Red Blood Cells

1997 • 4 citations

Overproduction of Nitric Oxide in Physiology and Pathophysiology: EPR Detection

1997 • 3 citations

General Discussion: Crossregulations of Metalloenzymes Triggered by Nitric Oxide

1997 • 2 citations

Deleted Work

1955 • 0 citations