The Physiological and Pathological Chemistry of Nitric Oxide

Methods in Enzymology , Vol

1966 • 26,261 citations

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

Superoxide Dismutase

1969 • 12,578 citations

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

1993 • 6,762 citations

Comprehensive Inorganic Chemistry

1973 • 3,014 citations

Biochemistry of Nitric Oxide and Its Redox-Activated Forms

1992 • 2,725 citations

Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain

1988 • 2,572 citations

Peroxynitrite oxidation of sulfhydryls.

1991 • 2,479 citations

Glutamate, nitric oxide and cell-cell signalling in the nervous system

1991 • 2,406 citations

Peroxynitrite-induced membrane lipid peroxidation: The cytotoxic potential of superoxide and nitric oxide

1991 • 2,215 citations

Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures.

1991 • 2,173 citations

The Reaction of no With Superoxide

1993 • 2,133 citations

Nitric oxide: A cytotoxic activated macrophage effector molecule

1988 • 2,050 citations

Endothelium‐derived relaxing and contracting factors

1989 • 2,017 citations

Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells.

1989 • 1,747 citations

Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate

1988 • 1,622 citations

Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria

1980 • 1,609 citations

Role of nitric oxide synthesis in macrophage antimicrobial activity

1991 • 1,547 citations

Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase

1992 • 1,499 citations

S-nitrosylation of proteins with nitric oxide: synthesis and characterization of biologically active compounds.

1992 • 1,454 citations

Biological effects of the superoxide radical

1986 • 1,446 citations

Peroxynitrite, a cloaked oxidant formed by nitric oxide and superoxide

1992 • 1,319 citations

How super is superoxide?

1981 • 1,294 citations

Biosynthesis and Metabolism of Endothelium-Derived Nitric Oxide

1990 • 1,284 citations

DNA Deaminating Ability and Genotoxicity of Nitric Oxide and its Progenitors

1991 • 1,223 citations

Extensive Nitration of Protein Tyrosines in Human Atherosclerosis Detected by Immunohistochemistry

1994 • 1,138 citations

A Requirement for the Intercellular Messenger Nitric Oxide in Long-Term Potentiation

1991 • 1,136 citations

Inhaled nitric oxide. A selective pulmonary vasodilator reversing hypoxic pulmonary vasoconstriction.

1991 • 1,134 citations

Peroxynitrite formation from macrophage-derived nitric oxide

1992 • 1,118 citations

Nitric oxide release from a single cell measured in situ by a porphyrinic-based microsensor

1992 • 1,063 citations

Vasorelaxant properties of the endothelium-derived relaxing factor more closely resemble S-nitrosocysteine than nitric oxide

1990 • 996 citations

Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells.

1991 • 982 citations

Correlation between nitric oxide formation during degradation of organic nitrates and activation of guanylate cyclase

1987 • 896 citations

Endogenous nitric oxide release required for long-term synaptic depression in the cerebellum

1991 • 875 citations

Oxidation of nitric oxide in aqueous solution to nitrite but not nitrate: comparison with enzymatically formed nitric oxide from L-arginine.

1993 • 832 citations

Kinetics of superoxide dismutase- and iron-catalyzed nitration of phenolics by peroxynitrite

1992 • 758 citations

Production of hydroxyl radicals from the simultaneous generation of superoxide and nitric oxide

1992 • 702 citations

Inhibition of Mitochondrial Electron Transport by Peroxynitrite

1994 • 697 citations

The NO hypothesis: possible effects of a short-lived, rapidly diffusible signal in the development and function of the nervous system.

1990 • 653 citations

Possible involvement of nitric oxide in long-term potentiation

1991 • 637 citations

Oxidation of nitrogen oxides by bound dioxygen in hemoproteins

1981 • 633 citations

Reduction Potentials Involving Inorganic Free Radicals in Aqueous Solution

1989 • 624 citations

N omega-hydroxy-L-arginine is an intermediate in the biosynthesis of nitric oxide from L-arginine.

1991 • 572 citations

Studies on the heterogeneity of hemoglobin

1965 • 567 citations

Electrostatic recognition between superoxide and copper, zinc superoxide dismutase

1983 • 540 citations

Signal transduction mechanisms involving nitric oxide

1991 • 538 citations

Reaction of superoxide with nitric oxide to form peroxonitrite in alkaline aqueous solution

1985 • 512 citations

Nitric oxide mediates neuronal death after focal cerebral ischemia in the mouse

1991 • 509 citations

Evidence for cytokine-inducible nitric oxide synthesis from L-arginine in patients receiving interleukin-2 therapy.

1992 • 494 citations

Neuronal Domains in Developing Neocortex

1992 • 493 citations

Evidence for In Vivo Peroxynitrite Production in Human Acute Lung Injury

1995 • 491 citations

Reactions of the bioregulatory agent nitric oxide in oxygenated aqueous media: Determination of the kinetics for oxidation and nitrosation by intermediates generated in the nitric oxide/oxygen reaction

1993 • 474 citations

Homogeneous chemiluminescent measurement of nitric oxide with ozone. Implications for continuous selective monitoring of gaseous air pollutants

1970 • 472 citations

The Simultaneous Generation of Superoxide and Nitric Oxide Can Initiate Lipid Peroxidation in Human Low Density Lipoprotein

1992 • 460 citations

Nitric oxide as an antioxidant

1991 • 441 citations

Bactericidal activity of peroxynitrite

1992 • 436 citations

Tissue injury caused by deposition of immune complexes is L-arginine dependent.

1991 • 436 citations

Superoxide dismutase and catalase conjugated to polyethylene glycol increases endothelial enzyme activity and oxidant resistance.

1988 • 425 citations

Superoxide production in experimental brain injury

1986 • 420 citations

An electrochemical microprobe for detecting nitric oxide release in brain tissue

1990 • 398 citations

Aromatic hydroxylation and nitration of phenylalanine and tyrosine by peroxynitrite

1994 • 377 citations

Peroxynitrite-induced luminol chemiluminescence

1993 • 371 citations

Kinetics of nitric oxide and hydrogen peroxide production and formation of peroxynitrite during the respiratory burst of human neutrophils

1994 • 369 citations

Cytoprotective function of nitric oxide: Inactivation of superoxide radicals produced by human leukocytes

1991 • 368 citations

Permeation of the erythrocyte stroma by superoxide radical

1978 • 367 citations

Why nitric oxide?

1992 • 350 citations

The chemistry of pernitrites. Part I. Kinetics of decomposition of pernitrous acid

1968 • 348 citations

Reactions of nitrogen dioxide in aqueous model systems: Oxidation of tyrosine units in peptides and proteins

1985 • 333 citations

EDRF coordinates the behaviour of vascular resistance vessels

1987 • 318 citations

The surprising life of NITRIC OXIDE

1993 • 316 citations

Role of L-arginine-nitric oxide pathway in myocardial reoxygenation injury

1992 • 312 citations

Reversible conversion of nitroxyl anion to nitric oxide by superoxide dismutase.

1991 • 307 citations

NMDA receptor activation in rat hippocampus induces cyclic GMP formation through the l-arginine-nitric oxide pathway

1991 • 301 citations

Oxidation of thiols by nitric oxide and nitrogen dioxide: synthetic utility and toxicological implications

1982 • 288 citations

Nitric oxide causes ADP-ribosylation and inhibition of glyceraldehyde-3-phosphate dehydrogenase.

1992 • 288 citations

Generation of EPR-detectable nitrosyl-iron complexes in tumor target cells cocultured with activated macrophages

1991 • 280 citations

Peroxynitrite modification of low‐density lipoprotein leads to recognition by the macrophage scavenger receptor

1993 • 279 citations

How far does ozone penetrate into the pulmonary air/tissue boundary before it reacts?

1992 • 274 citations

Nitric oxide stimulates auto-ADP-ribosylation of glyceraldehyde-3-phosphate dehydrogenase.

1992 • 271 citations

Comparison of superoxide with other reducing agents in the biological production of hydroxyl radicals

1979 • 268 citations

Peroxynitrite-induced rat colitis—A new model of colonic inflammation

1993 • 264 citations

Superoxide sensitivity of the Escherichia coli 6-phosphogluconate dehydratase

1991 • 259 citations

Mechanisms of Nitrogen Dioxide Reactions: Initiation of Lipid Peroxidation and the Production of Nitrous Acid

1981 • 256 citations

Agonist-Induced Peroxynitrite Production from Endothelial Cells

1994 • 254 citations

Inactivation of .alpha.1-proteinase inhibitor by peroxynitrite

1992 • 253 citations

Reaction of nitric oxide with heme proteins and model compounds of hemoglobin

1987 • 252 citations

Nitrotyrosine as a new marker for endogenous nitrosation and nitration of proteins

1990 • 249 citations

[4] Preparation of derivatives of ferrous and ferric hemoglobin

1981 • 245 citations

The Biological Basis of Learning and Individuality

1992 • 240 citations

Spontaneous liberation of nitric oxide cannot account for in vitro vascular relaxation by S-nitrosothiols.

1990 • 237 citations

Inhibition of Long-Term Potentiation by NMDA-Mediated Nitric Oxide Release

1992 • 233 citations

Mechanisms of peroxynitrite-induced injury to pulmonary surfactants

1993 • 232 citations

Peroxynitrite, a product of superoxide and nitric oxide, produces coronary vasorelaxation in dogs.

1994 • 232 citations

A stable solid that generates hydroxyl radical upon dissolution in aqueous solutions: reaction with proteins and nucleic acid

1992 • 229 citations

Absorption spectra and reaction kinetics of NO2, N2O3, and N2O4 in aqueous solution

1970 • 211 citations

On the pH-dependent yield of hydroxyl radical products from peroxynitrite

1994 • 202 citations

EPR detection of heme and nonheme iron-containing protein nitrosylation by nitric oxide during rejection of rat heart allograft.

1992 • 195 citations

Evidence for in vivo peroxynitrite production in human acute lung injury.

1995 • 193 citations

Reperfusion injury

1988 • 191 citations

FAD and GSH participate in macrophage synthesis of nitric oxide

1990 • 182 citations

Trapping of nitric oxide produced during denitrification by extracellular hemoglobin.

1988 • 176 citations

Concurrent generation of nitric oxide and superoxide damages surfactant protein A

1994 • 172 citations

Spin-Trapping Studies of Peroxynitrite Decomposition and of 3-Morpholinosydnonimine N-Ethylcarbamide Autooxidation: Direct Evidence for Metal-Independent Formation of Free-Radical Intermediates

1994 • 171 citations

Nitric oxide release from the isolated guinea pig heart

1988 • 153 citations

Nitrous Acid And Nitrosation

1959 • 152 citations

Diffusion coefficients of neon, krypton, xenon, carbon monoxide and nitric oxide in water at 10–60°C

1968 • 150 citations

Chemical synthesis with a quenched flow reactor. Hydroxytrihydroborate and peroxynitrite

1974 • 149 citations

Stoichiometry of the reaction of oxyhemoglobin with nitrite

1979 • 141 citations

Comparative pharmacology of EDRF and nitric oxide on vascular strips

1987 • 140 citations

Regulation of macrophage physiology by L-arginine: role of the oxidative L-arginine deiminase pathway.

1989 • 128 citations

The Distance That a Radical Formed by Ionizing Radiation Can Diffuse in a Yeast Cell

1957 • 126 citations

Peroxynitrite Inactivates Thiol-Containing Enzymes of Trypanosoma cruzi Energetic Metabolism and Inhibits Cell Respiration

1994 • 126 citations

Role of Conformation of Peroxynitrite Anion (ONOO-) with Its Stability and Toxicity

1994 • 118 citations

Interactions of light and sodium nitrite in producing relaxation of rabbit aorta.

1989 • 116 citations

Peroxynitrite inhibition of oxygen consumption and sodium transport in alveolar type II cells

1994 • 111 citations

Photolysis of the nitrogen-nitrogen double bond in trioxodinitrate: reaction between triplet oxonitrate(1-) and molecular oxygen to form peroxonitrite

1986 • 108 citations

Endothelium-derived relaxing factors. A perspective from in vivo data.

1990 • 104 citations

Examination of the role of arginine-143 in the human copper and zinc superoxide dismutase by site-specific mutagenesis.

1987 • 104 citations

Determination of trace levels of nitric oxide in aqueous solution

1980 • 104 citations

168. Pernitrous acid. The reaction between hydrogen peroxide and nitrous acid, and the properties of an intermediate product

1952 • 103 citations

Nitric oxide and hippocampal synaptic plasticity

1993 • 102 citations

Contribution of nitric oxide synthase to luminol-dependent chemiluminescence generated by phorbol-ester-activated Kupffer cells

1991 • 102 citations

Chemical influences on the specificity of tyrosine phosphorylation.

1990 • 101 citations

Kinetics of decomposition of peroxynitrous acid

1969 • 100 citations

Peroxynitrite and atherosclerosis

1993 • 99 citations

Photolysis of nitric acid in solid argon: the infrared absorption of peroxynitrous acid (HOONO)

1991 • 98 citations

Structure and absolute configuration of the marine sterol gorgosterol

1970 • 97 citations

Electron spin resonance study of the role of NO . catalase in the activation of guanylate cyclase by NaN3 and NH2OH. Modulation of enzyme responses by heme proteins and their nitrosyl derivatives.

1979 • 96 citations

Nitroprusside stimulates the cysteine‐specific mono(ADP‐ribosylation) of glyceraldehyde‐3‐phosphate dehydrogenase from human erythrocytes

1992 • 94 citations

Lung injury after deposition of IgA immune complexes. Requirements for CD18 and L-arginine.

1992 • 94 citations

Versatility and low-temperature synthetic potential of ammonium halides

1985 • 93 citations

The modulation of ferryl myoglobin formation and its oxidative effects on low density lipoproteins by nitric oxide

1991 • 93 citations

Structure of the ethylenediaminetetracetatoaquomagnesate(II) ion in a crystalline sodium salt. Comparative stereochemistry of the seven-coordinate chelates of magnesium(II), manganese(II), and iron(III)

1973 • 93 citations

Fluorometric determination of nitrite with 4-hydroxycoumarin

1986 • 92 citations

Evidence for the formation of hydroxyl radicals in the isomerization of pernitrous acid to nitric acid in aqueous solution

1970 • 88 citations

169. The nitration and hydroxylation of aromatic compounds by pernitrous acid

1952 • 87 citations

Release of NO and EDRF from cultured bovine aortic endothelial cells

1989 • 86 citations

Free radical yields from the homolysis of peroxynitrous acid

1992 • 86 citations

Protective effects of inhibitors of nitric oxide synthase in immune complex‐induced vasculitis

1992 • 82 citations

Redox reactivity of iron(III) porphyrins and heme proteins with nitric oxide. Nitrosyl transfer to carbon, oxygen, nitrogen and sulfur

1990 • 80 citations

The surprising life of nitric oxide

1993 • 78 citations

Comparison of spectrophotometric and biological assays for nitric oxide (NO) and endothelium-derived relaxing factor (EDRF): nonspecificity of the diazotization reaction for NO and failure to detect EDRF.

1990 • 73 citations

Peroxynitrite inhibits sodium uptake in rat colonic membrane vesicles

1992 • 73 citations

Mechanism of autocatalytic oxidation of oxyhemoglobin by nitrite an intermediate detected by electron spin resonance

1982 • 73 citations

Properties of a novel nitric oxide-stimulated ADP-ribosyltransferase

1990 • 71 citations

Crystal structure of peroxynitrite-modified bovine Cu,Zn superoxide dismutase

1992 • 68 citations

Color centers in UV-irradiated nitrates

1992 • 65 citations

A thermodynamic appraisal of the radical sink hypothesis

1993 • 62 citations

Isomers of nitric acid and chlorine nitrate

1988 • 61 citations

Chemical model for Viking biology experiments: implications for the composition of the martian regolith

1989 • 55 citations

Nitrosation of organic hydroperoxides by nitrogen dioxide/dinitrogen tetraoxide

1985 • 52 citations

Modification of human high density lipoprotein (HDL3) with tetranitromethane and the effect on its binding to isolated rat liver plasma membranes.

1985 • 51 citations

Anion exchange resins discriminate between nitric oxide and EDRF

1987 • 48 citations

The formation of peroxynitrite by oxidation of chloramine, hydroxylamine and nitrohydroxamate

1964 • 46 citations

Infrared Absorption by Peroxy-Nitrogen Trioxide Free Radical in the Gas Phase

1965 • 44 citations

Nitroglycerin Tolerance in Vitro: Effect on cGMP Turnover in Vascular Smooth Muscle

1984 • 43 citations

An ab initio characterization of nitrogen trioxide electronic states

1989 • 42 citations

Nitric oxide: The Jekyll and Hyde of gut inflammation

1993 • 42 citations

Die Einwirkung von Ozon auf Alkaliazid. Persalpetrige Säure I

1929 • 41 citations

The chemistry of peroxonitrites. Part III. The reaction of peroxonitrite with nucleophiles in alkali, and other nitrite producing reactions

1971 • 40 citations

The chemistry of peroxonitrites. Part II. Copper(II)-catalysed reaction between hydroxylamine and peroxonitrite in alkali

1970 • 39 citations

Ueber die salpetrige Säure

1901 • 38 citations

Responses of rabbit aorta to nitric oxide and superoxide generated by ultraviolet irradiation of solutions containing inorganic nitrite.

1991 • 37 citations

Reactions of Fe(II)‐ATP and Fe(II)‐citrate complexes with t‐butyl hydroperoxide and cumyl hydroperoxide

1990 • 36 citations

Considered onium ions. Part 40. Protonitronium dication, (NO2H2+)

1992 • 35 citations

Tetramethyl‐ortho‐chinodimethan (NOCT‐1), das erste Mitglied einer Familie maßgeschneiderter cheletroper Spinfänger für Stickstoffmonoxid

1992 • 33 citations

Bactericidal agents generated by the peroxidase-catalyzed oxidation of para-hydroquinones.

1985 • 33 citations

Reactions of Nitrogen(II) Oxide

1962 • 29 citations

Comparison of the role of tyrosine residues in human IgG and rabbit IgG in binding of complement subcomponent C1q

1989 • 27 citations

Superoxide Theory of Oxygen Toxicity Is Center of Heated Debate

1984 • 25 citations

Chemical modification of cytochrome P-450 LM4. Identification of functionally linked tyrosine residues

1987 • 24 citations

Die Einwirkung von Wasserstoffsuperoxyd auf salpetrige Säure. Persalpetrige Säure. II

1935 • 24 citations

Reaction of Cytochrome c with Nitrite and Nitric Oxide

1978 • 23 citations

Electronic structure and spectra of the peroxynitrite anion

1994 • 23 citations

Heat of isomerization of peroxynitrite to nitrate and kinetics of isomerization of peroxynitrous acid to nitric acid

1962 • 21 citations

On the mechanism of H+ translocation by mitochondrial H+-ATPase. Studies with chemical modifier of tyrosine residues

1984 • 20 citations

The reaction of bovine alpha-thrombin with tetranitromethane. Characterization of the modified protein.

1988 • 19 citations

Chemical modification of human α1-proteinase inhibitor by tetranitromethane. Structure-function relationship

1987 • 18 citations

Decreased production of nitric oxide by human neutrophils during septic multiple organ dysfunction syndrome

1994 • 18 citations

Ab initio calculations on ONOOH and ONOO?

1993 • 17 citations

Comparison of the nitration of polyfluoronitrobenzenes by nitronium salts in superacidic and aprotic media: activation of the nitronium ion by protosolvation.

1992 • 16 citations

ChemInform Abstract: Photolysis of the N = N Bond in Trioxodinitrate: Reaction Between Triplet NO‐ and O₂ to Form Peroxonitrite.

1986 • 12 citations

Interferences in environmental analysis of nitric oxide by nitric oxide pulse ozone detectors: a rapid screening technique

1986 • 8 citations

Peroxynitrite stimulates cgmp synthesis by vascular smooth muscle

1992 • 1 citations

Deleted Work

1955 • 0 citations