Binding of Nitric Oxide and Carbon Monoxide to Soluble Guanylate Cyclase As Observed with Resonance Raman Spectroscopy

A simple method for displaying the hydropathic character of a protein

1982 • 22,471 citations

Hemoglobin and myoglobin in their reactions with ligands

1971 • 2,698 citations

Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain

1988 • 2,572 citations

Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum.

1989 • 1,850 citations

Principles of structure, bonding, and reactivity for metal nitrosyl complexes

1974 • 1,577 citations

Biological Applications of Raman Spectroscopy

2000 • 1,100 citations

The Pharmacological and Physiological Role of Cyclic GMP in Vascular Smooth Muscle Relaxation

1985 • 685 citations

Soluble Guanylate Cyclase from Bovine Lung: Activation with Nitric Oxide and Carbon Monoxide and Spectral Characterization of the Ferrous and Ferric States

1994 • 641 citations

Oxidation of nitrogen oxides by bound dioxygen in hemoproteins

1981 • 633 citations

Endothelium‐dependent inhibition of platelet aggregation

1986 • 540 citations

High-Resolution Crystal Structures of Distal Histidine Mutants of Sperm Whale Myoglobin

1993 • 386 citations

Endothelium‐derived relaxing factor inhibits in vitro platelet aggregation

1987 • 367 citations

Why nitric oxide?

1992 • 350 citations

Structural correlations and vinyl influences in resonance Raman spectra of protoheme complexes and proteins

1982 • 288 citations

How far can proteins bend the FeCO unit? Distal polar and steric effects in heme proteins and models

1994 • 283 citations

Structural Determinants of the Stretching Frequency of CO Bound to Myoglobin

1994 • 276 citations

An infrared study of nitric oxide bonding to heme B and hemoglobin A. Evidence for inositol hexaphosphate induced cleavage of proximal histidine to iron bonds

1976 • 272 citations

The anatomy of a bifunctional enzyme: Structural basis for reduction of oxygen to water and synthesis of nitric oxide by cytochrome cd1

1995 • 260 citations

Nitrosylmetalloporphyrins. II. Synthesis and molecular stereochemistry of nitrosyl-.alpha.,.beta.,.gamma.,.delta.-tetraphenylporphinatoiron(II)

1975 • 228 citations

Activation of purified soluble guanylate cyclase by protoporphyrin IX.

1982 • 206 citations

Is bound carbonyl linear or bent in heme proteins? Evidence from resonance Raman and infrared spectroscopic data

1988 • 188 citations

Resonance Raman investigation of carbon monoxide bonding in (carbon monoxy)hemoglobin and -myoglobin: detection of iron-carbon monoxide stretching and iron-carbon-oxygen bending vibrations and influence of the quaternary structure change

1982 • 181 citations

Distal residues in the oxygen binding site of haemoglobin studied by protein engineering

1987 • 160 citations

Spectral transitions of nitrosyl hemes during ligand binding to hemoglobin.

1979 • 158 citations

Electron Paramagnetic Resonance Spectral Evidence for the Formation of a Pentacoordinate Nitrosyl-Heme Complex on Soluble Guanylate Cyclase

1995 • 153 citations

Studies of the Heme Coordination and Ligand Binding Properties of Soluble Guanylyl Cyclase (sGC): Characterization of Fe(II)sGC and Fe(II)sGC(CO) by Electronic Absorption and Magnetic Circular Dichroism Spectroscopies and Failure of CO To Activate the Enzyme

1995 • 128 citations

Nitrosylmetalloporphyrins. III. Synthesis and molecular stereochemistry of nitrosyl-.alpha.,.beta.,.gamma.,.delta.-tetraphenylporphinato(1-methylimidazole)iron(II)

1976 • 122 citations

Differences in Fe(II)-N epsilon(His-F8) stretching frequencies between deoxyhemoglobins in the two alternative quaternary structures.

1980 • 122 citations

Correlation of carbon-13 and oxygen-17 chemical shifts and the vibrational frequency of electrically perturbed carbon monoxide: a possible model for distal ligand effects in carbonmonoxyheme proteins

1991 • 116 citations

Distal and proximal ligand interactions in heme proteins: correlations between carbon-oxygen and iron-carbon vibrational frequencies, oxygen-17 and carbon-13 nuclear magnetic resonance chemical shifts, and oxygen-17 nuclear quadrupole coupling constants in [C17O-] and [13CO]-labeled species

1991 • 110 citations

Electrochemical and spectroscopic studies of iron porphyrin nitrosyls and their reduction products

1991 • 109 citations

Resonance Raman studies of nitric oxide binding to ferric and ferrous hemoproteins: detection of Fe(III)--NO stretching, Fe(III)--N--O bending, and Fe(II)--N--O bending vibrations.

1983 • 106 citations

Requirement for heme in the activation of purified guanylate cyclase by nitric oxide

1983 • 96 citations

Two types of conformers with distinct Fe-C-O configuration in the ferrous CO complex of horseradish peroxidase. Resonance Raman and infarared spectroscopic studies with native and deuteroheme-substituted enzymes.

1987 • 92 citations

Heme Stoichiometry of Heterodimeric Soluble Guanylate Cyclase

1995 • 90 citations

Resonance Raman and electronic spectra of heme a complexes and cytochrome oxidase

1983 • 89 citations

Resonance Raman Spectroscopy of Soluble Guanylyl Cyclase Reveals Displacement of Distal and Proximal Heme Ligands by NO

1994 • 89 citations

Factors affecting the iron-oxygen vibrations of ferrous oxy and ferryl oxo heme proteins and model compounds

1990 • 87 citations

The dissociation of NO from nitrosylhemoglobin.

1978 • 86 citations

Distal pocket polarity in ligand binding to myoglobin: structural and functional characterization of a threonine68 (E11) mutant

1991 • 78 citations

Resonance Raman investigation of nitric oxide bonding in nitrosylhemoglobin A and -myoglobin: detection of bound nitrogen-oxygen stretching and iron-nitric oxide stretching vibrations from the hexacoordinated nitric oxide-heme complex

1982 • 73 citations

The Ferrous Heme of Soluble Guanylate Cyclase: Formation of Hexacoordinate Complexes with Carbon Monoxide and Nitrosomethane

1995 • 70 citations

Resonance Raman studies of carbon monoxide binding to iron "picket fence" porphyrin with unhindered and hindered axial bases. An inverse relationship between binding affinity and the strength of iron-carbon bond

1983 • 67 citations

Resonance Raman evidence for cleavage of the Fe-N.epsilon.(His-F8) bond in the .alpha. subunit of the T-structure nitrosylhemoglobin

1980 • 50 citations

Spectroscopic characterization of cytochrome ba3, a terminal oxidase from Thermus thermophilus: Comparison of the a3/CuB site to that of bovine cytochrome aa3

1994 • 46 citations

Comparison of the resonance Raman spectra of carbon monoxy and oxy hemoglobin and myoglobin. Similarities and differences in heme electron distribution

1975 • 46 citations

The Proximal Residue Largely Determines the CO Distortion in Carbon Monoxy Globin Proteins. An ab Initio Study of a Heme Prosthetic Unit

1995 • 45 citations

The Proximal Residue Largely Determines the CO Distortion in Carbonmonoxy Globin Proteins. An ab Initio Study of a Heme Prosthetic Unit

1994 • 45 citations

Effects of cholesterol and adrenodoxin binding on the heme moiety of cytochrome P-450scc: a resonance Raman study

1986 • 41 citations

Time-resolved resonance Raman study on the binding of carbon monoxide to recombinant human myoglobin and its distal histidine mutants

1993 • 38 citations

Resonance Raman detection of v(Fe-CO) stretching frequency in cytochrome P-450scc from bovine adrenocortical mitochondria

1985 • 34 citations

Ligand binding properties of cytochromes c′

1991 • 33 citations

Resonance Raman investigation of nitric oxide bonding in iron porphyrins: detection of the Fe-NO stretching vibration

1993 • 28 citations

Determination of iron-carbon monoxide geometry in the subunits of carbonmonoxy hemoglobin M Boston using femtosecond infrared spectroscopy

1993 • 27 citations

Optical and resonance Raman spectroscopy of the heme groups of the quinol-oxidizing cytochrome aa3 of Bacillus subtilis

1992 • 24 citations

Effect of the distal residues on the vibrational modes of the iron-carbon monoxide bond in hemoglobin studied by protein engineering

1990 • 24 citations

The vibrational bands of carbon monoxide bound to hemes or metal surfaces

1985 • 16 citations

Resonance Raman study on pentacoordinated and hexacoordinated ferrous nitrosyl myoglobin

1983 • 13 citations

Novel heme: O2 bonding of possible relevance to oxygen utilizing heme and other proteins

1974 • 12 citations