General Discussion: Crossregulations of Metalloenzymes Triggered by Nitric Oxide

Carbon Monoxide: a Putative Neural Messenger

1993 • 1,519 citations

Nitric oxide activates cyclooxygenase enzymes.

1993 • 1,416 citations

Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide

1994 • 1,214 citations

Nitric Oxide Activation of Poly(ADP-Ribose) Synthetase in Neurotoxicity

1994 • 1,138 citations

Nitrite and nitrate determinations in plasma: a critical evaluation

1995 • 1,095 citations

Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase

1994 • 1,026 citations

Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation.

1994 • 1,026 citations

Methods in nitric oxide research

1996 • 826 citations

Generation of superoxide by purified brain nitric oxide synthase.

1992 • 765 citations

Methods in Nitric Oxide Research

1997 • 726 citations

Soluble Guanylate Cyclase from Bovine Lung: Activation with Nitric Oxide and Carbon Monoxide and Spectral Characterization of the Ferrous and Ferric States

1994 • 641 citations

A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter.

1995 • 630 citations

Nitric oxide synthase is a cytochrome P-450 type hemoprotein

1992 • 617 citations

Nitric oxide regulates mitochondrial respiration and cell functions by inhibiting cytochrome oxidase

1995 • 540 citations

The high-output nitric oxide pathway: role and regulation

1994 • 512 citations

Nitric oxide-induced p53 accumulation and regulation of inducible nitric oxide synthase expression by wild-type p53.

1996 • 455 citations

Diffusion of Nitric Oxide in the Aorta Wall Monitored in Situ by Porphyrinic Microsensors

1993 • 418 citations

Metabolism and excretion of nitric oxide in humans. An experimental and clinical study.

1993 • 404 citations

Heme oxygenase 2: endothelial and neuronal localization and role in endothelium-dependent relaxation.

1996 • 401 citations

An electrochemical microprobe for detecting nitric oxide release in brain tissue

1990 • 398 citations

Feedback inhibition of nitric oxide synthase activity by nitric oxide

1993 • 396 citations

Nitric oxide-induced S-nitrosylation of glyceraldehyde-3-phosphate dehydrogenase inhibits enzymatic activity and increases endogenous ADP-ribosylation.

1992 • 390 citations

An Experimental and Clinical Study

1966 • 379 citations

Negative feedback regulation of endothelial cell function by nitric oxide.

1993 • 371 citations

Cloned, expressed rat cerebellar nitric oxide synthase contains stoichiometric amounts of heme, which binds carbon monoxide.

1992 • 368 citations

Indoleamine 2,3-dioxygenase. Purification and some properties

1978 • 362 citations

Inhibition of Cytochromes P450 by Nitric Oxide and a Nitric Oxide-Releasing Agent

1993 • 358 citations

Arginase Induction by Suppressors of Nitric Oxide Synthesis (IL-4, IL-10 and PGE2) in Murine Bone-Marrow-Derived Macrophages

1995 • 358 citations

Spectral characterization of brain and macrophage nitric oxide synthases. Cytochrome P-450-like hemeproteins that contain a flavin semiquinone radical.

1992 • 344 citations

Quantitative and kinetic characterization of nitric oxide and EDRF released from cultured endothelial cells

1988 • 342 citations

Nitric Oxide Potently and Reversibly Deenergizes Mitochondria at Low Oxygen Tension

1994 • 324 citations

Reversible Binding of Nitric Oxide by a Salivary Heme Protein from a Bloodsucking Insect

1993 • 312 citations

The mode of action of aspirin-like drugs: effect on inducible nitric oxide synthase.

1995 • 310 citations

Alterations of ribonucleotide reductase activity following induction of the nitrite-generating pathway in adenocarcinoma cells.

1990 • 284 citations

Reversible Binding and Inhibition of Catalase by Nitric Oxide

1995 • 277 citations

Nitric oxide stimulates auto-ADP-ribosylation of glyceraldehyde-3-phosphate dehydrogenase.

1992 • 271 citations

Nitric oxide, an inhibitor of lipid oxidation by lipoxygenase, cyclooxygenase and hemoglobin

1992 • 254 citations

Constitutive nitric oxide synthase from cerebellum is reversibly inhibited by nitric oxide formed from L-arginine

1992 • 254 citations

IL-1.beta. induces the coexpression of both nitric oxide synthase and cyclooxygenase by Islets of Langerhans: activation of cyclooxygenase by nitric oxide

1993 • 253 citations

Endogenous nitric oxide inhibits the synthesis of cyclooxygenase products and interleukin-6 by rat Kupffer cells

1993 • 248 citations

Formation of free nitric oxide from l-arginine by nitric oxide synthase: direct enhancement of generation by superoxide dismutase.

1994 • 247 citations

Mitochondrial Nitric Oxide Synthase: A Ubiquitous Regulator of Oxidative Phosphorylation?

1996 • 244 citations

Vascular Smooth Muscle Cell Heme Oxygenases Generate Guanylyl Cyclase–Stimulatory Carbon Monoxide

1995 • 244 citations

Nitric Oxide Produced by Endothelial Cells Increases Production of Eicosanoids Through Activation of Prostaglandin H Synthase

1995 • 239 citations

Differential effects of cytokines on the inducible expression of CYP1A1, CYP1A2, and CYP3A4 in human hepatocytes in primary culture

1995 • 238 citations

Loss and Degradation of Enzyme-bound Heme Induced by Cellular Nitric Oxide Synthesis

1995 • 237 citations

Inducible nitric oxide synthase from a rat alveolar macrophage cell line is inhibited by nitric oxide.

1993 • 225 citations

Nitric Oxide:Biochemistry, Pathophysiology, and Detection

1993 • 221 citations

Nitric oxide mediates norepinephrine-induced prostaglandin E2 release from the hypothalamus.

1992 • 219 citations

On the expression of nitric oxide synthase by human macrophages. Why no NO?

1995 • 218 citations

Co-induction of Arginase and Nitric Oxide Synthase in Murine Macrophages Activated by Lipopolysaccharide

1995 • 213 citations

Inhibition of hippocampal heme oxygenase, nitric oxide synthase, and long-term potentiation by metalloporphyrins

1994 • 209 citations

Shear Stress Induces ATP-Independent Transient Nitric Oxide Release From Vascular Endothelial Cells, Measured Directly With a Porphyrinic Microsensor

1995 • 209 citations

Cross-talk between cyclooxygenase and nitric oxide pathways: prostaglandin E2 negatively modulates induction of nitric oxide synthase by interleukin 1.

1994 • 207 citations

Nitric oxide inhibits indoleamine 2,3-dioxygenase activity in interferon-gamma primed mononuclear phagocytes.

1994 • 207 citations

Inhibition of cytochrome c oxidase in turnover by nitric oxide: mechanism and implications for control of respiration

1995 • 207 citations

Nitric oxide produced by activated astrocytes rapidly and reversibly inhibits cellular respiration

1995 • 204 citations

Immunocytochemical Evidence for a Mitochondrially Located Nitric Oxide Synthase in Brain and Liver

1995 • 204 citations

Parallel induction of tetrahydrobiopterin biosynthesis and indoleamine 2,3-dioxygenase activity in human cells and cell lines by interferon-γ

1989 • 201 citations

Nitric oxide inhibits neuronal nitric oxide synthase by interacting with the heme prosthetic group. Role of tetrahydrobiopterin in modulating the inhibitory action of nitric oxide.

1994 • 199 citations

Inhibition of cytochromes P4501A by nitric oxide.

1994 • 198 citations

Regulation of nitric oxide synthase by nitric oxide.

1993 • 197 citations

Neuronal Nitric Oxide Synthase Self-inactivates by Forming a Ferrous-Nitrosyl Complex during Aerobic Catalysis

1995 • 195 citations

Quenching of the tyrosyl free radical of ribonucleotide reductase by nitric oxide. Relationship to cytostasis induced in tumor cells by cytotoxic macrophages.

1994 • 187 citations

Carbon Monoxide: An Emerging Regulator of cGMP in the Brain

1993 • 185 citations

Human macrophages degrade tryptophan upon induction by interferon-gamma

1987 • 182 citations

[26] Indoleamine 2,3-dioxygenase

1987 • 176 citations

Inhibition of Rat Liver Arginase by an Intermediate in NO Biosynthesis, NG-Hydroxy-L-arginine: Implications for the Regulation of Nitric Oxide Biosynthesis by Arginase

1994 • 174 citations

Nω-Hydroxy-L-Arginine, an Intermediate in the L-Arginine to Nitric Oxide Pathway, Is a Strong Inhibitor of Liver and Macrophage Arginase

1994 • 170 citations

Studies on indoleamine 2,3-dioxygenase. I. Superoxide anion as substrate.

1975 • 167 citations

Purification, Partial Characterization, and Cloning of Nitric Oxide-carrying Heme Proteins (Nitrophorins) from Salivary Glands of the Blood-sucking Insect Rhodnius prolixus

1995 • 165 citations

Direct measurement of nitric oxide in human beings

1995 • 165 citations

Electron Paramagnetic Resonance Spectral Evidence for the Formation of a Pentacoordinate Nitrosyl-Heme Complex on Soluble Guanylate Cyclase

1995 • 153 citations

Role of nitric oxide in eicosanoid synthesis and uterine motility in estrogen-treated rat uteri.

1994 • 152 citations

Brain nitric oxide synthase is a haemoprotein

1992 • 151 citations

Early loss of the tyrosyl radical in ribonucleotide reductase of adenocarcinoma cells producing nitric oxide

1992 • 144 citations

High affinity histamine-binding and antihistaminic activity of the salivary nitric oxide-carrying heme protein (nitrophorin) of Rhodnius prolixus.

1994 • 142 citations

Kinetics and Mechanism of Tetrahydrobiopterin-induced Oxidation of Nitric Oxide

1995 • 142 citations

Studies of the oxygen binding site of cytochrome P-450. Nitric oxide as a spin-label probe.

1978 • 134 citations

Interaction Between Nitric Oxide and Prostaglandin H Synthase

1994 • 132 citations

Coinduction of Nitric Oxide Synthase, Argininosuccinate Synthetase, and Argininosuccinate Lyase in Lipopolysaccharide-treated Rats

1996 • 128 citations

Induction of heart heme oxygenase-1 (HSP32) by hyperthermia: possible role in stress-mediated elevation of cyclic 3':5'-guanosine monophosphate.

1994 • 124 citations

Oxidative-stress response in vascular endothelial cells exposed to acellular hemoglobin solutions

1995 • 122 citations

Inhibition of arginase by in alveolar macrophages: implications for the utilization of <scp>l</scp>‐arginine for nitric oxide synthesis

1995 • 120 citations

Spectral Characterization and Effect on Catalytic Activity of Nitric Oxide Complexes of Inducible Nitric Oxide Synthase

1995 • 119 citations

Regulation of nitric-oxide synthase mRNA expression by interferon-gamma and picolinic acid.

1994 • 119 citations

Cytochrome P450 catalyzes the oxidation of Nω-hydroxy-L-arginine by NADPH and O2 to nitric oxide and citrulline

1992 • 117 citations

Mediation of inflammation by encephalitogenic cells: interferon γ induction of nitric oxide synthase and cyclooxygenase 2

1995 • 115 citations

EPR evidence for binuclear manganese(II) centers in rat liver arginase

1992 • 113 citations

Heme coordination of NO in NO synthase.

1994 • 112 citations

Formation of nitrogen oxides and citrulline upon oxidation of Nω-hydroxy-L-arginine by hemeproteins

1992 • 111 citations

Loss of Calcium Responsiveness in Cultured Bovine Parathyroid Cells Is Associated with Decreased Calcium Receptor Expression

1995 • 110 citations

Nitric oxide formation during microsomal hepatic denitration of glyceryl trinitrate: Involvement of cytochrome P-450

1989 • 109 citations

Sol–gel encapsulation of metalloproteins for the development of optical biosensors for nitrogen monoxide and carbon monoxide

1995 • 102 citations

Particular Ability of Liver P450s3a to Catalyze the Oxidation of Nω-Hydroxyarginine to Citrulline and Nitrogen Oxides and Occurrence in NO Synthases of a Sequence Very Similar to the Heme-Binding Sequence in P450s

1993 • 101 citations

Detection of endothelial-derived relaxing factor in human plasma in the basal state and following ischemia using electron paramagnetic resonance spectrometry

1990 • 97 citations

Direct and reversible inhibition of endothelial nitric oxide synthase by nitric oxide

1995 • 97 citations

Electron spin resonance investigation of tyrosyl radicals of prostaglandin H synthase. Relation to enzyme catalysis.

1991 • 96 citations

Characterization of the tyrosyl radicals in ovine prostaglandin H synthase-1 by isotope replacement and site-directed mutagenesis.

1994 • 95 citations

Nitric Oxide Limits Transcriptional Induction of Nitric Oxide Synthase in CNS Glial Cells

1994 • 95 citations

Elevated manganese concentration and arginase activity in livers of streptozotocin-induced diabetic rats.

1983 • 93 citations

Heme Stoichiometry of Heterodimeric Soluble Guanylate Cyclase

1995 • 90 citations

Comparison of Substrate and Inhibitor Specificity of Arginase and Nitricm Oxide (NO) Synthase for Arginine Analogs and Related Compounds in Murine and Rat Macrophages

1994 • 90 citations

Reversible Inactivation of Calpain Isoforms by Nitric Oxide

1995 • 88 citations

A Salivary Nitrophorin (Nitric-Oxide-Carrying Hemoprotein) in the Bedbug Cimex Lectularius

1995 • 87 citations

Heme Oxygenase-2

1995 • 85 citations

Nitric oxide synthase activity from a hematophagous insect salivary gland

1993 • 83 citations

Nitric Oxide Reversibly Suppresses Xanthine Oxidase Activity

1994 • 79 citations

Hypoxia activates nitric oxide synthase and stimulates nitric oxide production in porcine coronary resistance arteriolar endothelial cells

1995 • 77 citations

Direct Measurement of Nitric Oxide Production in Platelets: Relationship with Cytosolic Ca2+ Concentration

1995 • 75 citations

Nitric oxide complexes of cytochrome P‐450

1975 • 72 citations

Cytochrome c Oxidase Catalysis of the Reduction of Nitric Oxide to Nitrous Oxide

1995 • 72 citations

Endothelium-derived relaxing factor released from canine femoral artery by acetylcholine cannot be identified as free nitric oxide by electron paramagnetic resonance spectroscopy.

1990 • 71 citations

Reaction of peroxynitrite with oxyhaemoglobin: interference with photometrical determination of nitric oxide

1994 • 71 citations

EPR study of ferric native prostaglandin H synthase and its ferrous NO derivative

1987 • 70 citations

The Ferrous Heme of Soluble Guanylate Cyclase: Formation of Hexacoordinate Complexes with Carbon Monoxide and Nitrosomethane

1995 • 70 citations

Characterization by Electron Paramagnetic Resonance of the Interactions of L-Arginine and L-Thiocitrulline with the Heme Cofactor Region of Nitric Oxide Synthase

1995 • 66 citations

Tetrahydrobiopterin-deficient nitric oxide synthase has a modified heme environment and forms a cytochrome P 420 analog

1995 • 65 citations

Modulation of Heme Oxygenase Activity in Rat Brain and Spleen by Inhibitors and Donors of Nitric Oxide

1995 • 64 citations

Formation of nitric oxide by cytochrome P450-catalyzed oxidation of aromatic amidoximes

1992 • 63 citations

Selective Inhibition of the 12-Lipoxygenase Pathway of Arachidonic Acid Metabolism by L-Arginine or Sodium Nitroprusside in Intact Human Platelets

1994 • 60 citations

Intracellular utilization of superoxide anion by indoleamine 2,3-dioxygenase of rabbit enterocytes.

1977 • 59 citations

Demonstration That Histidine-25, But Not Histidine-132, Is the Axial Heme Ligand in Rat Heme Oxygenase-1

1995 • 59 citations

The role of arginase in the immune response

1985 • 58 citations

Rhodnius prolixus: Salivary Antihemostatic Components Decrease with Trypanosoma rangeli Infection

1994 • 58 citations

Nitric Oxide Loading of the Salivary Nitric-Oxide-Carrying Hemoproteins (Nitrophorins) in the Blood-Sucking BUG Rhodnius Prolixus

1995 • 56 citations

Interleukin-1 Enhances Pancreatic Islet Arachidonic Acid 12-Lipoxygenase Product Generation by Increasing Substrate Availability through a Nitric Oxide-dependent Mechanism

1996 • 55 citations

Evidence for cyclooxygenase activation by nitric oxide in astrocytes

1995 • 55 citations

Heme Oxygenase, a Likely Regulator of cGMP Production in the Brain: Induction in Vivo of HO-1 Compensates for Depression in NO Synthase Activity

1993 • 54 citations

On the mechanism of nitric oxide formation upon oxidative cleavage of CN(OH) bonds by NO-synthases and cytochromes P450

1995 • 52 citations

Nω-Hydroxyamino-α-amino acids as a new class of very strong inhibitors of arginases

1996 • 52 citations

Nitroglycerin metabolism by Phanerochaete chrysosporium: evidence for nitric oxide and nitrite formation

1991 • 51 citations

Infrared Characterization of Nitric Oxide Bonding to Bovine Heart Cytochrome c Oxidase and Myoglobin

1994 • 51 citations

Nitric Oxide-Donor Compounds Inhibit Lipoxygenase Activity

1996 • 47 citations

Heme oxygenase: the physiological role of one of its metabolites, carbon monoxide and interactions with zinc protoporphyrin, cobalt protoporphyrin and other metalloporphyrins.

1994 • 42 citations

Inhibition of nitric oxide synthase by a superoxide generating system.

1993 • 41 citations

Glyceraldehyde-3-phosphate dehydrogenase is required for the transport of nitric oxide in platelets.

1993 • 40 citations

Inhibition by sodium nitroprusside of the expression of inducible nitric oxide synthase in rat neutrophils

1995 • 39 citations

EPR Spectroscopic Characterization of Neuronal NO Synthase

1996 • 37 citations

Nitric oxide inactivates xanthine dehydrogenase and xanthine oxidase in interferon-gamma-stimulated macrophages.

1994 • 36 citations

Particular ability of cytochrome P-450 CYP3A to reduce glyceryl trinitrate in rat liver microsomes: Subsequent formation of nitric oxide

1993 • 36 citations

Spectroscopic and electrochemical response to nitrogen monoxide of a cationic iron porphyrin immobilized in nafion-coated electrodes or membranes

1994 • 35 citations

Effect of Nitric Oxide Synthase Substrate Analog Inhibitors on Rat Liver Arginase

1993 • 34 citations

Electron paramagnetic resonance study of ferrous cytochrome P-450scc-nitric oxide complexes: effects of cholesterol and its analogs

1987 • 33 citations

The Interactions between Nitric Oxide and Brain Nerve Terminals as Studied by Electron Paramagnetic Resonance

1995 • 27 citations

The Protective Effect of Tetrahydrobiopterin on the Nitric Oxide-Mediated Inhibition of Purified Nitric Oxide Synthase

1995 • 26 citations

Characterization of sites occupied by the anesthetic nitrous oxide within proteins by infrared spectroscopy.

1994 • 26 citations

Multiple enzymatic pathways involved in the metabolism of glyceryl trinitrate in Phanerochaete chrysosporium

1992 • 25 citations

Cytokine‐mediated production of nitric oxide in isolated rat hepatocytes is dependent on cytochrome P‐450III activity

1995 • 22 citations

[Voltametric detection of cerebral NO in rats. Variations of the signal throughout the sleep-wakefulness cycle].

1996 • 21 citations

Contributions of NO Synthase and Heme Oxygenase to cGMP Formation by Cytokine and Hemin-Treated Brain Capillary Endothelial Cells

1995 • 20 citations

Evidence that carbon monoxide is a mediator of critical illness.

1994 • 19 citations

Nitric oxide formation during the cytochrome P-450-dependent reductive metabolism of 18-nitro-oxyandrostenedione.

1995 • 15 citations

Factors influencing macrophage activation by muramyl peptides: inhibition of NO synthase activity by high levels of NO

1994 • 8 citations

[Action duality of nitrogen oxide (NO) in experimental African trypanosomiasis].

1996 • 8 citations

Interleukin-1 activates preferentially cyclooxygenase rather than NO synthase pathway in human smooth muscle cells

1994 • 3 citations

EPR Spectroscopic Characterization of Neuronal NO Synthase

1996 • 3 citations