Regulation of both apoptosis and cell survival by the v-Src oncoprotein

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

1997 • 5,665 citations

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

Molecular characterization of mitochondrial apoptosis-inducing factor

1999 • 4,031 citations

PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo

1995 • 3,456 citations

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

1994 • 3,285 citations

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).

1994 • 3,249 citations

Disruption of epithelial cell-matrix interactions induces apoptosis

1994 • 3,167 citations

Regulation of Cell Death Protease Caspase-9 by Phosphorylation

1998 • 3,129 citations

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

1996 • 3,065 citations

Two CD95 (APO-1/Fas) signaling pathways

1998 • 3,045 citations

Induction of apoptosis in fibroblasts by c-myc protein

1992 • 2,977 citations

Mechanism of activation of protein kinase B by insulin and IGF-1.

1996 • 2,965 citations

Oncogenes and signal transduction

1991 • 2,816 citations

Serine Phosphorylation of Death Agonist BAD in Response to Survival Factor Results in Binding to 14-3-3 Not BCL-XL

1996 • 2,627 citations

Selective interaction of JNK protein kinase isoforms with transcription factors.

1996 • 1,333 citations

Mechanisms and consequences of activation of protein kinase B/Akt

1998 • 1,305 citations

Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB

1997 • 1,162 citations

Bcl-2 family proteins

1998 • 1,055 citations

Antiapoptotic Signalling by the Insulin-Like Growth Factor I Receptor, Phosphatidylinositol 3-Kinase, and Akt

1997 • 1,051 citations

Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

1997 • 1,050 citations

Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation assays.

1993 • 997 citations

Inhibition of Human Caspases by Peptide-based and Macromolecular Inhibitors

1998 • 984 citations

Apoptotic cell death induced by c-myc is inhibited by bcl-2

1992 • 981 citations

Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2

1990 • 910 citations

Daxx, a Novel Fas-Binding Protein That Activates JNK and Apoptosis

1997 • 797 citations

Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis.

1994 • 772 citations

Cooperative interaction between c-myc and bcl-2 proto-oncogenes

1992 • 766 citations

Membrane and Morphological Changes in Apoptotic Cells Regulated by Caspase-Mediated Activation of PAK2

1997 • 742 citations

Protein kinase cascades activated by stress and inflammatory cytokines

1996 • 722 citations

ASK1 Is Essential for JNK/SAPK Activation by TRAF2

1998 • 641 citations

Activation of Apoptosis Signal-Regulating Kinase 1 (ASK1) by the Adapter Protein Daxx

1998 • 596 citations

Caspases and caspase inhibitors

1997 • 573 citations

Anchorage and growth regulation in normal and virus‐transformed cells

1968 • 547 citations

Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis.

1994 • 515 citations

The Regulation of Anoikis: MEKK-1 Activation Requires Cleavage by Caspases

1997 • 507 citations

Activation of extracellular signal-regulated kinase, ERK2, by p21ras oncoprotein.

1992 • 490 citations

Benzyloxycarbonyl-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32

1996 • 481 citations

Activating SRC mutation in a subset of advanced human colon cancers

1999 • 473 citations

Cleavage of p21Cip1/Waf1 and p27Kip1 Mediates Apoptosis in Endothelial Cells through Activation of Cdk2: Role of a Caspase Cascade

1998 • 441 citations

Mechanisms of apoptosis by c-Myc

1999 • 430 citations

Subcellular and submitochondrial mode of action of Bcl-2-like oncoproteins

1998 • 421 citations

Caspase-dependent Cleavage of Signaling Proteins during Apoptosis

1998 • 420 citations

SAPK2/p38-dependent F-Actin Reorganization Regulates Early Membrane Blebbing during Stress-induced Apoptosis

1998 • 303 citations

The catalytic activity of Src is dispensable for translocation to focal adhesions but controls the turnover of these structures during cell motility

1998 • 290 citations

Activation of the pp60c-src protein kinase is an early event in colonic carcinogenesis.

1990 • 280 citations

pp60c-src activation in human colon carcinoma.

1989 • 267 citations

Tumor Necrosis Factor Signaling to Stress-activated Protein Kinase (SAPK)/Jun NH2-terminal Kinase (JNK) and p38

1998 • 267 citations

A role for Jun-N-terminal kinase in anoikis; suppression by bcl-2 and crmA.

1996 • 250 citations

Stress signals for apoptosis: ceramide and c-Jun kinase

1998 • 211 citations

Oncogenic Ras inhibits Fas ligand-mediated apoptosis by downregulating the expression of Fas

1999 • 159 citations

TRAIL/Apo2L Activates c-Jun NH2-terminal Kinase (JNK) via Caspase-dependent and Caspase-independent Pathways

1998 • 144 citations

Comparison of Caspase Activation and Subcellular Localization in HL-60 and K562 Cells Undergoing Etoposide-Induced Apoptosis

1997 • 140 citations

Mitogen-activated Protein Kinase Kinase Antagonized Fas-associated Death Domain Protein–mediated Apoptosis by Induced FLICE-inhibitory Protein Expression

1998 • 132 citations

Targeted proteolysis of the focal adhesion kinase pp125 FAK during c-MYC-induced apoptosis is suppressed by integrin signalling.

1996 • 128 citations

Traps to catch unwary oncogenes

1998 • 113 citations

Comparison of Caspase Activation and Subcellular Localization in HL-60 and K562 Cells Undergoing Etoposide-Induced Apoptosis

1997 • 106 citations

The selective isolation of temperature-sensitive mutants of Rous sarcoma virus

1973 • 103 citations

v-Src-induced degradation of focal adhesion kinase during morphological transformation of chicken embryo fibroblasts.

1995 • 83 citations

The opposing roles of the Akt and c-Myc signalling pathways in survival from CD95-mediated apoptosis

1998 • 69 citations

Inhibition of Fas-induced apoptosis by Bcl-2

1998 • 65 citations

Complementation of Defective Colony-Stimulating Factor 1 Receptor Signaling and Mitogenesis by Raf and v-Src

1999 • 56 citations

Expression of the v-Src oncoprotein in fibroblasts disrupts normal regulation of the CDK inhibitor p27 and inhibits quiescence

1998 • 52 citations

A method of isolating cells incapable of multiplication in supension culture

1971 • 32 citations

Transformation by v-Jun prevents cell cycle exit and promotes apoptosis in the absence of serum growth factors.

1997 • 22 citations

Mitogenesis by v-Src: fluctuations throughout G1 of classical immediate early AP-1 and mitogen-activated protein kinase responses that parallel the need for the oncoprotein.

1995 • 19 citations

Mitogenesis by v-Src: a need for active oncoprotein both in leaving G0 and in completing G1 phases of the cell cycle.

1993 • 16 citations

c‐myc Gene activation as a permanent trait of RSV‐infected quail cells

1993 • 10 citations