JNK and p38 MAP kinases in CD4⁺ and CD8⁺ T cells

Signal Transduction by the JNK Group of MAP Kinases

2000 • 4,096 citations

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

1994 • 3,285 citations

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

A MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian Cells

1994 • 2,659 citations

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1992 • 2,618 citations

SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase

2001 • 2,488 citations

Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine

1995 • 2,238 citations

Selective interaction of JNK protein kinase isoforms with transcription factors.

1996 • 1,333 citations

Is a p53-Regulated Inhibitor of G2/M Progression

1997 • 1,238 citations

JNK is involved in signal integration during costimulation of T lymphocytes

1994 • 929 citations

14-3-3σ is required to prevent mitotic catastrophe after DNA damage

1999 • 895 citations

Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of hsp27

1994 • 866 citations

Defective T Cell Differentiation in the Absence of Jnk1

1998 • 590 citations

Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function.

1996 • 504 citations

Differentiation of CD4+ T Cells to Th1 Cells Requires MAP Kinase JNK2

1998 • 454 citations

Control points in early T-cell development

1993 • 429 citations

Interferon-gamma expression by Th1 effector T cells mediated by the p38 MAP kinase signaling pathway

1998 • 425 citations

Apoptosis of CD8+ T cells is mediated by macrophages through interaction of HIV gp120 with chemokine receptor CXCR4

1998 • 411 citations

Requirement for the Leukocyte-Specific Adapter Protein SLP-76 for Normal T Cell Development

1998 • 405 citations

Role of CSBP/p38/RK stress response kinase in LPS and cytokine signaling mechanisms

1996 • 396 citations

Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3(Mkk3)-deficient mice

1999 • 390 citations

JNK is required for effector T-cell function but not for T-cell activation

2000 • 322 citations

JNK2 is required for efficient T-cell activation and apoptosis but not for normal lymphocyte development

1999 • 305 citations

AP-1 transcriptional activity requires both T-cell receptor-mediated and co-stimulatory signals in primary T lymphocytes.

1994 • 288 citations

A role for the p38 mitogen-acitvated protein kinase pathway in the transcriptional activation of p53 on genotoxic stress by chemotherapeutic agents.

2000 • 264 citations

Cross-talk between ERK and p38 MAPK Mediates Selective Suppression of Pro-inflammatory Cytokines by Transforming Growth Factor-β

2002 • 234 citations

Activation changes the spectrum but not the diversity of genes expressed by T cells

1999 • 227 citations

The JNK Pathway Regulates the In Vivo Deletion of Immature CD4+CD8+ Thymocytes

1998 • 221 citations

Molecular determinants that mediate selective activation of p38 MAP kinase isoforms

2000 • 219 citations

C-Jun Nh2-Terminal Kinase (Jnk)1 and Jnk2 Have Similar and Stage-Dependent Roles in Regulating T Cell Apoptosis and Proliferation

2001 • 219 citations

Differential Roles of ERK and p38 MAP Kinase Pathways in Positive and Negative Selection of T Lymphocytes

1998 • 217 citations

Blocking activator protein-1 activity, but not activating retinoic acid response element, is required for the antitumor promotion effect of retinoic acid

1997 • 213 citations

Hemopoietic Growth Factors with the Exception of Interleukin-4 Activate the p38 Mitogen-activated Protein Kinase Pathway

1997 • 172 citations

Role of the Guanosine Triphosphatase Rac2 in T Helper 1 Cell Differentiation

2000 • 170 citations

GADD45γ Mediates the Activation of the p38 and JNK MAP Kinase Pathways and Cytokine Production in Effector TH1 Cells

2001 • 161 citations

c-Jun NH2-Terminal Kinase (JNK)1 and JNK2 Have Distinct Roles in CD8+ T Cell Activation

2002 • 137 citations

Pre-TCR Signaling and Inactivation of p53 Induces Crucial Cell Survival Pathways in Pre-T Cells

1999 • 122 citations

Reprogramming the signalling requirement for AP‐1 (activator protein‐1) activation during differentiation of precursor CD4⁺ T‐cells into effector Th1 and Th2 cells

1997 • 115 citations

p53 prevents maturation to the CD4+CD8+ stage of thymocyte differentiation in the absence of T cell receptor rearrangement.

1996 • 106 citations

Activation of p38 Mitogen-Activated Protein Kinase In Vivo Selectively Induces Apoptosis of CD8⁺ but Not CD4⁺ T Cells

2000 • 98 citations

Activation of the p38 Mitogen-Activated Protein Kinase Pathway Arrests Cell Cycle Progression and Differentiation of Immature Thymocytes in Vivo

2000 • 97 citations

Effect of anti-interleukin 12 treatment on murine lyme borreliosis.

1996 • 96 citations

Regulation of c-Jun NH2-terminal Kinase ( Jnk) Gene Expression during T Cell Activation

2000 • 93 citations

Regulation of FAS Ligand Expression during Activation-Induced Cell Death in T Cells by p38 Mitogen-Activated Protein Kinase and C-Jun Nh2-Terminal Kinase

2000 • 87 citations

c-Jun NH2-Terminal Kinase (JNK)1 and JNK2 Signaling Pathways Have Divergent Roles in CD8+ T Cell–mediated Antiviral Immunity

2002 • 85 citations

The p38MAPK Inhibitor SB203580 Alleviates Ultraviolet-Induced Phosphorylation at Serine 389 but Not Serine 15 and Activation of p53

1999 • 78 citations

Development of CD4+CD8+ thymocytes in RAG-deficient mice through a T cell receptor β chain-independent pathway.

1995 • 74 citations

The basis for TCR-mediated regulation of the IL-2 receptor alpha chain gene: role of widely separated regulatory elements

2002 • 72 citations

Intrathymic signals in thymocytes are mediated by p38 mitogen-activated protein kinase.

1996 • 66 citations

Mouse Interleukin-2 Receptor α Gene Expression

1995 • 62 citations

Extracellular Signal–Regulated Kinase (Erk) Activation by the Pre-T Cell Receptor in Developing Thymocytes in Vivo

1999 • 46 citations

Murine Lyme Arthritis Development Mediated by p38 Mitogen-Activated Protein Kinase Activity

2002 • 35 citations

Pyridinyl imidazoles inhibit the inflammatory phase of delayed type hypersensitivity reactions without affecting T-dependent immune responses

1994 • 24 citations

Activation of p38 MAP kinase in T cells facilitates the immune response to the influenza virus

2000 • 18 citations