Ex Vivo Generation of Human Anti–Pre-B Leukemia-Specific Autologous Cytolytic T Cells

Quantitative assay of the lytic action of immune lymphoid cells on 51-Cr-labelled allogeneic target cells in vitro; inhibition by isoantibody and by drugs.

1968 • 1,363 citations

Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation.

1991 • 1,132 citations

Cloning of B7-2: a CTLA-4 Counter-Receptor That Costimulates Human T Cell Proliferation

1993 • 911 citations

B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4

1995 • 577 citations

Induction of Immune Responses in Patients with B-Cell Lymphoma against the Surface-Immunoglobulin Idiotype Expressed by Their Tumors

1992 • 551 citations

Identification of target antigens for the human cytotoxic T cell response to Epstein-Barr virus (EBV): implications for the immune control of EBV-positive malignancies.

1992 • 519 citations

B-cell surface antigen B7 provides a costimulatory signal that induces T cells to proliferate and secrete interleukin 2.

1991 • 445 citations

Participation of target Fas protein in apoptosis pathway induced by CD4+ Th1 and CD8+ cytotoxic T cells.

1994 • 309 citations

Soluble CD40 ligand can replace the normal T cell-derived CD40 ligand signal to B cells in T cell-dependent activation.

1993 • 261 citations

T-cell-mediated cytotoxicity against autologous malignant melanoma: analysis with interleukin 2-dependent T-cell cultures.

1984 • 237 citations

Alloreactive cloned T cell lines. I. Interactions between cloned amplifier and cytolytic T cell lines.

1980 • 235 citations

Follicular lymphomas can be induced to present alloantigen efficiently: a conceptual model to improve their tumor immunogenicity.

1995 • 224 citations

Cells that present both specific ligand and costimulatory activity are the most efficient inducers of clonal expansion of normal CD4 T cells.

1992 • 214 citations

B7 but not intercellular adhesion molecule-1 costimulation prevents the induction of human alloantigen-specific tolerance.

1993 • 205 citations

Pre-B acute lymphoblastic leukemia cells may induce T-cell anergy to alloantigen

1996 • 173 citations

T-cell Clonal Anergy

1989 • 163 citations

Cytotoxic T cell clones isolated from ovarian tumor-infiltrating lymphocytes recognize multiple antigenic epitopes on autologous tumor cells.

1991 • 159 citations

Generation of leukemia-reactive cytotoxic T lymphocyte clones from the HLA-identical bone marrow donor of a patient with leukemia.

1992 • 158 citations

Pre-B acute lymphoblastic leukemia cells may induce T-cell anergy to alloantigen

1996 • 149 citations

Clonal analysis of cytotoxic T cell response against human melanoma.

1983 • 138 citations

Tumor immunotherapy: the tumor cell as an antigen-presenting cell

1994 • 132 citations

Cloned T-Cell Lines with Specific Cytolytic Activity

1979 • 127 citations

Distinct Ir genes for helper and killer cells in the cytotoxic response to H-Y antigen.

1979 • 122 citations

Establishment of human cytotoxic T cell lines specific for human adult T cell leukemia virus-bearing cells.

1983 • 121 citations

Recognition of the Epstein-Barr virus-encoded nuclear antigens EBNA-4 and EBNA-6 by HLA-A11-restricted cytotoxic T lymphocytes: implications for down-regulation of HLA-A11 in Burkitt lymphoma.

1992 • 110 citations

T-cell lines which cooperate in generation of specific cytolytic activity

1979 • 105 citations

Human cytotoxic T-cell lines with restricted specificity for squamous cell carcinoma of the head and neck.

1993 • 95 citations

MHC class‐I‐restricted auto‐tumor‐specific CD4⁺CD8 ⁻T‐cell clones established from autologous mixed lymphocyte‐tumor‐cell culture (MLTC)

1992 • 81 citations

Generation of an HLA-restricted cytotoxic T cell line reactive against cultured tumor cells from a patient infected with human T cell leukemia/lymphoma virus.

1983 • 80 citations

Cellular immune response to human sarcomas: cytotoxic T cell clones reactive with autologous sarcomas. I. Development, phenotype, and specificity.

1986 • 77 citations

Susceptibility to cytotoxic T lymphocyte-induced apoptosis is a function of the proliferative status of the target.

1994 • 77 citations

Cell‐mediated cytotoxicity for cultured autologous melanoma cells

1979 • 58 citations

Tumor Cells Expressing Major Histocompatibility Complex Class II and B7 Activation Molecules Stimulate Potent Tumor-Specific Immunity

1993 • 29 citations

The critical role of CD28 signalling in the prevention of human T-cell anergy

1995 • 15 citations