Mice Lacking p27 Display Increased Body Size, Multiple Organ Hyperplasia, Retinal Dysplasia, and Pituitary Tumors

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

The retinoblastoma protein and cell cycle control

1995 • 4,873 citations

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

1993 • 3,680 citations

p21 is a universal inhibitor of cyclin kinases

1993 • 3,408 citations

Inhibitors of mammalian G1 cyclin-dependent kinases.

1995 • 3,258 citations

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

1992 • 2,969 citations

G1 phase progression: Cycling on cue

1994 • 2,706 citations

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

1994 • 2,154 citations

Cyclins and cancer II: Cyclin D and CDK inhibitors come of age

1994 • 2,122 citations

Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

1995 • 2,115 citations

p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21

1994 • 2,071 citations

p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest.

1994 • 1,970 citations

pl5INK4B is a potentia| effector of TGF-β-induced cell cycle arrest

1994 • 1,932 citations

Role of the Ubiquitin-Proteasome Pathway in Regulating Abundance of the Cyclin-Dependent Kinase Inhibitor p27

1995 • 1,848 citations

Effects of an Rb mutation in the mouse

1992 • 1,779 citations

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

1988 • 1,690 citations

Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth.

1986 • 1,617 citations

Cloning of Senescent Cell-Derived Inhibitors of DNA Synthesis Using an Expression Screen

1994 • 1,368 citations

Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene

1991 • 1,317 citations

A novel cyclin encoded by a bcl1-linked candidate oncogene

1991 • 1,286 citations

Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

1992 • 1,285 citations

Radiation-induced cell cycle arrest compromised by p21 deficiency

1995 • 1,249 citations

Germline p16 mutations in familial melanoma

1994 • 1,241 citations

Correlation of Terminal Cell Cycle Arrest of Skeletal Muscle with Induction of p21 by MyoD

1995 • 1,154 citations

Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages

1992 • 1,116 citations

p53-Independent Expression of p21 ^Cip1 in Muscle and Other Terminally Differentiating Cells

1995 • 1,058 citations

Cyclin D1 provides a link between development and oncogenesis in the retina and breast

1995 • 1,017 citations

Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta.

1995 • 959 citations

p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene.

1995 • 956 citations

Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution.

1995 • 910 citations

lnterleukin-2-mediated elimination of the p27Kipl cyclin-dependent kinase inhibitor prevented by rapamycin

1994 • 903 citations

Teratocarcinomas and embryonic stem cells : a practical approach

1987 • 878 citations

Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit

1993 • 778 citations

Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function.

1994 • 731 citations

Mice lacking cyclin D1 are small and show defects in eye and mammary gland development.

1995 • 681 citations

Amplification and overexpression of cyclin D1 in breast cancer detected by immunohistochemical staining.

1994 • 673 citations

Novel INK4 Proteins, p19 and p18, Are Specific Inhibitors of the Cyclin D-Dependent Kinases CDK4 and CDK6

1995 • 657 citations

Crucial role of the pre-T-cell receptor α gene in development of ap but not γδ T cells

1995 • 519 citations

Induction of differentiation in human promyelocytic HL-60 leukemia cells activates p21, WAF1/CIP1, expression in the absence of p53.

1994 • 514 citations

Induction of p21 (WAF-1/CIP1) during differentiation.

1994 • 493 citations

Transgenic mice with a rhodopsin mutation (Pro23His): A mouse model of autosomal dominant retinitis pigmentosa

1992 • 454 citations

Inflammatory and immunomodulatory roles of TGF-β

1989 • 450 citations

Disappearance of the Lymphoid System in Bcl-2 Homozygous Mutant Chimeric Mice

1993 • 402 citations

Absence of WAF1 mutations in a variety of human malignancies

1994 • 390 citations

D11S287, a putative oncogene on chromosome 11q13, is amplified and expressed in squamous cell and mammary carcinomas and linked to BCL-1.

1991 • 376 citations

Frequent somatic mutation of the MTS1/CDK4I (multiple tumor suppressor/cyclin-dependent kinase 4 inhibitor) gene in esophageal squamous cell carcinoma.

1994 • 345 citations

p27Kip1: chromosomal mapping to 12p12-12p13.1 and absence of mutations in human tumors.

1995 • 338 citations

Identification of Human and Mouse p19, a Novel CDK4 and CDK6 Inhibitor with Homology to p16^ink4

1995 • 336 citations

Kinetics of mature T-cell development in the thymus.

1990 • 331 citations

Inherited retinal dystrophy in the RCS rat: Prevention of photoreceptor degeneration by pigment epithelial cell transplantation

1988 • 329 citations

Molecular analysis of the cyclin-dependent kinase inhibitor gene p27/Kip1 in human malignancies.

1995 • 327 citations

Inactivation of a Cdk2 inhibitor during interleukin 2-induced proliferation of human T lymphocytes.

1994 • 289 citations

Extensive contribution of Rb-deficient cells to adult chimeric mice with limited histopathological consequences.

1994 • 289 citations

N-(Phosphonacetyl)-l-Aspartate, a Potent Transition State Analog Inhibitor of Aspartate Transcarbamylase, Blocks Proliferation of Mammalian Cells in Culture

1974 • 217 citations

Assignment of the human p27Kip1 gene to 12p13 and its analysis in leukemias.

1995 • 207 citations

Effect of transforming growth factor-beta on early and late activation events in human T cells.

1993 • 137 citations

Alterations of the p27KIP1 gene in non-Hodgkin's lymphomas and adult T- cell leukemia/lymphoma

1995 • 134 citations

Chromosomal mapping of members of the cdc2 family of protein kinases, cdk3, cdk6, PISSLRE, and PITALRE, and a cdk inhibitor, p27Kip1, to regions involved in human cancer.

1995 • 113 citations

Requirement for CD8 β Chain in Positive Selection of CD8-Lineage T Cells

1994 • 110 citations

Inactivation of a Cdk2 Inhibitor during Interleukin 2-Induced Proliferation of Human T Lymphocytes

1994 • 94 citations

Molecular Cloning and Identification of Two Types of Hamster Cyclin-Dependent Kinases: CDK2 and CDK2L

1993 • 17 citations

Retinopathic effects of 2-aminooxy propionic acid derivatives in the rat

1979 • 12 citations

Deletion 12p in de novo acute myeloid leukemia

1992 • 9 citations