Barbiturates Induce Mitochondrial Depolarization and Potentiate Excitotoxic Neuronal Death

THE [¹⁴C]DEOXYGLUCOSE METHOD FOR THE MEASUREMENT OF LOCAL CEREBRAL GLUCOSE UTILIZATION: THEORY, PROCEDURE, AND NORMAL VALUES IN THE CONSCIOUS AND ANESTHETIZED ALBINO RAT¹

1977 • 5,986 citations

Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assay

1987 • 1,280 citations

Glutamate becomes neurotoxic via the N-methyl-d-aspartate receptor when intracellular energy levels are reduced

1988 • 972 citations

Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?

1992 • 964 citations

Intracellular Oxidation-Reduction States in Vivo

1962 • 936 citations

Glutamate-induced neuron death requires mitochondrial calcium uptake

1998 • 623 citations

Mitochondrial membrane potential and neuronal glutamate excitotoxicity: mortality and millivolts

2000 • 564 citations

Molecular mechanisms of calcium-dependent excitotoxicity

2000 • 467 citations

Inhibition of Electron and Energy Transfer in Mitochondria

1963 • 363 citations

Mitochondrial Membrane Potential and Glutamate Excitotoxicity in Cultured Cerebellar Granule Cells

2000 • 308 citations

Mitochondria in Neurodegeneration: Bioenergetic Function in Cell Life and Death

1999 • 294 citations

Mitochondria and Na+/Ca2+ exchange buffer glutamate-induced calcium loads in cultured cortical neurons

1995 • 292 citations

Pentobarbitone pharmacology of mammalian central neurones grown in tissue culture.

1978 • 284 citations

Bioenergetics and glutamate excitotoxicity

1996 • 245 citations

Glutamate‐induced mitochondrial depolarisation and perturbation of calcium homeostasis in cultured rat hippocampal neurones

1999 • 211 citations

Ion homeostasis in brain cells: differences in intracellular ion responses to energy limitation between cultured neurons and glial cells

1997 • 201 citations

Effect of Thiopental on Neurologic Outcome Following Coronary Artery Bypass Grafting

1991 • 188 citations

Ionized intracellular calcium concentration predicts excitotoxic neuronal death: observations with low-affinity fluorescent calcium indicators.

1997 • 169 citations

Barbiturate anesthesia in the treatment of status epilepticus

1988 • 169 citations

Acidosis Potentiates Oxidative Neuronal Death by Multiple Mechanisms

1999 • 163 citations

A Rapid, Quantitative Fluorescence Assay for Cell Damage by Cytotoxic Antibodies

1970 • 154 citations

Ionized Intracellular Calcium Concentration Predicts Excitotoxic Neuronal Death: Observations with Low-Affinity Fluorescent Calcium Indicators

1997 • 149 citations

Astrocyte energetics, function, and death under conditions of incomplete ischemia: A mechanism of glial death in the penumbra

1997 • 138 citations

Pentobarbital and EEG Burst Suppression in Treatment of Status Epilepticus Refractory to Benzodiazepines and Phenytoin

1990 • 132 citations

Astrocyte glutamate uptake during chemical hypoxia in vitro

1992 • 116 citations

Barbiturates and oxidative phosphorylation

1960 • 114 citations

Pharmacodynamic modeling of thiopental anesthesia

1984 • 100 citations

3-Nitropropionic acid exacerbates N-methyl-d-aspartate toxicity in striatal culture by multiple mechanisms

1998 • 81 citations

Barbiturates decrease voltage-dependent calcium conductance of mouse neurons in dissociated cell culture.

1985 • 64 citations

Reevaluation of Potency and Pharmacokinetic Properties of some Lipid‐soluble Barbiturates with an EEG‐threshoJd Method

1984 • 60 citations

INTRAVENOUS AGENTS AND INTRAOPERATIVE NEUROPROTECTION

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Mechanisms of barbiturate protection.

1980 • 48 citations

Mechanisms of Barbiturate Protection

1980 • 46 citations

Intracellular Oxidation-Reduction States in Vivo

1962 • 45 citations

Selective Inhibition of Transient K⁺ Current by La³⁺ in Crab Peptide-Secretory Neurons

1999 • 36 citations

Thiopental sodium cerebral protection during carotid endarterectomy: Perioperative disease and death

1994 • 28 citations

Drug glucosidation

1990 • 26 citations

Plasma and cerebrospinal fluid barbiturate levels during prolonged continuous thiopentone infusion

1982 • 26 citations

Barbiturates impair astrocyte glutamate uptake

1998 • 21 citations

Effect of Anesthetic and Convulsant Barbiturates on N-Methyl-D-Aspartate Receptor-Mediated Calcium Flux in Brain Membrane Vesicles

1994 • 20 citations

Secobarbital Attenuates Excitotoxicity but Potentiates Oxygen—Glucose Deprivation Neuronal Injury in Cortical Cell Culture

1993 • 19 citations

Pentobarbitone modulation of NMDA receptors in neurones isolated from the rat olfactory brain

1995 • 17 citations

Product enantioselectivity in the N-glucosylation of amobarbital.

1986 • 17 citations

Comparison of Anaesthetic and Kinetic Properties of Thiobutabarbital, Butabarbital and Hexobarbital after Intravenous Threshold Doses in the Male Rat

1989 • 11 citations

Effects of pentobarbital and pentothal on rat heart contractile force and oxidative phosphorylation activities

1980 • 9 citations

Barbital N-glucoside is not detected as a urinary excretion product of barbital in humans

1991 • 2 citations