New Functions for Non-collagenous Domains of Human Collagen Type IV

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

Endostatin: An Endogenous Inhibitor of Angiogenesis and Tumor Growth

1997 • 4,504 citations

Requirement of Vascular Integrin α _v β ₃ for Angiogenesis

1994 • 3,016 citations

Angiogenesis.

1992 • 2,581 citations

Integrin αvβ3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels

1994 • 2,293 citations

Definition of Two Angiogenic Pathways by Distinct α _v Integrins

1995 • 1,333 citations

The implications of angiogenesis for the biology and therapy of cancer metastasis

1994 • 1,120 citations

Structure and biological activity of basement membrane proteins

1989 • 967 citations

Antiintegrin alpha v beta 3 blocks human breast cancer growth and angiogenesis in human skin.

1995 • 840 citations

Two different laminin domains mediate the differentiation of human endothelial cells into capillary-like structures in vitro

1989 • 746 citations

Disruption of Angiogenesis by PEX, a Noncatalytic Metalloproteinase Fragment with Integrin Binding Activity

1998 • 618 citations

Type IV collagen: structure, gene organization, and role in human diseases. Molecular basis of Goodpasture and Alport syndromes and diffuse leiomyomatosis.

1993 • 610 citations

Tumor interactions with the vasculature: angiogenesis and tumor metastasis

1990 • 598 citations

Biosynthetic and functional properties of an Arg-Gly-Asp-directed receptor involved in human melanoma cell attachment to vitronectin, fibrinogen, and von Willebrand factor.

1987 • 574 citations

Peptides derived from two separate domains of the matrix protein thrombospondin-1 have anti-angiogenic activity

1993 • 574 citations

Angiogenesis promoted by vascular endothelial growth factor: Regulation through α₁β₁and α₂β₁ integrins

1997 • 516 citations

How does extracellular matrix control capillary morphogenesis?

1989 • 466 citations

Collagen IV alpha 3, alpha 4, and alpha 5 chains in rodent basal laminae: sequence, distribution, association with laminins, and developmental switches.

1994 • 403 citations

Suppression of p53 activity and p21WAF1/CIP1 expression by vascular cell integrin alphaVbeta3 during angiogenesis.

1996 • 385 citations

A hierarchy of ECM-mediated signalling regulates tissue-specific gene expression

1995 • 378 citations

Integrins alpha v beta 3 and alpha v beta 5 contribute to cell attachment to vitronectin but differentially distribute on the cell surface.

1991 • 357 citations

An α2β1 Integrin-Dependent Pinocytic Mechanism Involving Intracellular Vacuole Formation and Coalescence Regulates Capillary Lumen and Tube Formation in Three-Dimensional Collagen Matrix

1996 • 352 citations

Basal lamina assembly

1994 • 322 citations

Molecular and functional defects in kidneys of mice lacking collagen alpha 3(IV): implications for Alport syndrome.

1996 • 310 citations

Deletion of the Paired α5(IV) and α6(IV) Collagen Genes in Inherited Smooth Muscle Tumors

1993 • 294 citations

Basement membrane (type IV) collagen

1995 • 283 citations

Antiangiogenic Activity of Restin, NC10 Domain of Human Collagen XV: Comparison to Endostatin

1999 • 280 citations

Differential expression of two basement membrane collagen genes, COL4A6 and COL4A5, demonstrated by immunofluorescence staining using peptide-specific monoclonal antibodies.

1995 • 277 citations

Receptor tyrosine kinase signaling required for integrin alpha v beta 5-directed cell motility but not adhesion on vitronectin.

1994 • 276 citations

Inhibition of angiogenesis through modulation of collagen metabolism.

1988 • 240 citations

Characterization of a type IV collagen major cell binding site with affinity to the alpha 1 beta 1 and the alpha 2 beta 1 integrins.

1991 • 230 citations

Interaction of type IV collagen with the isolated integrins α1β1 and α2β1

1993 • 215 citations

The collagenous components of the subendothelium. Correlation of structure and function.

1980 • 197 citations

Role of integrins in angiogenesis

1996 • 191 citations

Requirement of the NPXY motif in the integrin beta 3 subunit cytoplasmic tail for melanoma cell migration in vitro and in vivo.

1995 • 186 citations

Insulin-like growth factor receptor cooperates with integrin alpha v beta 5 to promote tumor cell dissemination in vivo.

1997 • 170 citations

Assembly of extracellular matrix

1992 • 159 citations

Phage antibodies with pan-species recognition of the oncofoetal angiogenesis marker fibronectin ED-B domain

1996 • 151 citations

The effect of nonenzymatic glucosylation on the binding of the main noncollagenous NC1 domain to type IV collagen.

1988 • 147 citations

Antibodies to β₁‐integrins cause alterations of aortic vasculogenesis, in vivo

1992 • 126 citations

Comparative distribution of the alpha 1(IV), alpha 5(IV), and alpha 6(IV) collagen chains in normal human adult and fetal tissues and in kidneys from X-linked Alport syndrome patients.

1995 • 116 citations

Characterization of a synthetic peptide from type IV collagen that promotes melanoma cell adhesion, spreading, and motility.

1990 • 114 citations

Ultrastructural, physiological, and molecular defects in the inner ear of a gene-knockout mouse model for autosomal Alport syndrome

1998 • 109 citations

Type IV collagen-mediated melanoma cell adhesion and migration: involvement of multiple, distinct domains of the collagen molecule.

1989 • 96 citations

Induction of anti-GBM nephritis in rats by recombinant α3(IV)NC1 and α4(IV)NC1 of type IV collagen

1998 • 93 citations

The role of the main noncollagenous domain (NC1) in type IV collagen self-assembly.

1986 • 89 citations

Construction of a model for the aggregation and cross-linking region (7S domain) of type IV collagen based upon an evaluation of the primary structure of the alpha1 and alpha2 chains in this region

1987 • 80 citations

Basement membranes: molecular organization and function in development and disease

1989 • 78 citations

Comparative analysis of the noncollagenous NC1 domain of type IV collagen: Identification of structural features important for assembly, function, and pathogenesis

1998 • 66 citations

Hydra Cell Aggregate Development Is Blocked by Selective Fragments of Fibronectin and Type IV Collagen

1994 • 62 citations

Differential tissular expression and localization of type IV collagen alpha1(IV), alpha2(IV), alpha5(IV), and alpha6(IV) chains and their mRNA in normal breast and in benign and malignant breast tumors.

1999 • 53 citations

Loss of type IV collagen alpha 5 and alpha 6 chains in human invasive prostate carcinomas.

1997 • 52 citations

Identification of a multifunctional, cell-binding peptide sequence from the a1(NC1) of type IV collagen.

1990 • 50 citations

The Function of the NC1 Domains in Type IV Collagen

1995 • 49 citations

There Is Temporal and Spatial Expression of α1 (IV), α2 (IV), α5 (IV), α6 (IV) Collagen Chains and β1 Integrins During the Development of the Basal Lamina in an “In Vitro” Skin Model

1997 • 47 citations

Endothelial Cell‐Extracellular Matrix Interactionsa

1985 • 43 citations

There Is Binding of Collagen IV to β1 Integrin during Early Skin Basement Membrane Assembly

1998 • 39 citations

Interactions of Type IV Collagen and Its Domains with Human Mesangial Cells

1998 • 36 citations

Antiangiogenic drugs as a novel anticancer therapeutic strategy

1997 • 20 citations