Genomic insulators: connecting properties to mechanism

Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene

2000 • 1,706 citations

CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus

2000 • 1,493 citations

The Protein CTCF Is Required for the Enhancer Blocking Activity of Vertebrate Insulators

1999 • 1,076 citations

Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles

1995 • 822 citations

Transitions in Distinct Histone H3 Methylation Patterns at the Heterochromatin Domain Boundaries

2001 • 746 citations

The Human Transcriptome Map: Clustering of Highly Expressed Genes in Chromosomal Domains

2001 • 736 citations

Insulators: many functions, many mechanisms

2002 • 635 citations

Correlation Between Histone Lysine Methylation and Developmental Changes at the Chicken β-Globin Locus

2001 • 582 citations

Clustering of housekeeping genes provides a unified model of gene order in the human genome

2002 • 551 citations

A computational analysis of whole-genome expression data reveals chromosomal domains of gene expression

2000 • 532 citations

Evidence for large domains of similarly expressed genes in the Drosophila genome

2002 • 483 citations

Interphase chromosomes in Arabidopsis are organized as well defined chromocenters from which euchromatin loops emanate

2002 • 446 citations

DNA position-specific repression of transcription by a Drosophila zinc finger protein.

1992 • 418 citations

Heterochromatin: new possibilities for the inheritance of structure

2002 • 402 citations

Characterization of the chicken β-globin insulator

1997 • 381 citations

Position-effect protection and enhancer blocking by the chicken β-globin insulator are separable activities

2002 • 380 citations

Position effect in human genetic disease

1998 • 374 citations

The boundaries of the silenced HMR domain in Saccharomyces cerevisiae

1999 • 370 citations

Transitions in histone acetylation reveal boundaries of three separately regulated neighboring loci

2001 • 362 citations

Chromatin Boundaries in Budding Yeast

2002 • 352 citations

A Chromatin Insulator Determines the Nuclear Localization of DNA

2000 • 337 citations

Visualization of chromosomal domains with boundary element-associated factor BEAF-32

1995 • 321 citations

CTCF-binding sites flank CTG/CAG repeats and form a methylation-sensitive insulator at the DM1 locus

2001 • 318 citations

Limitations of silencing at native yeast telomeres

1999 • 297 citations

Gene density and transcription influence the localization of chromatin outside of chromosome territories detectable by FISH

2002 • 292 citations

RNA polymerase III and RNA polymerase II promoter complexes are heterochromatin barriers in Saccharomyces cerevisiae

2001 • 280 citations

Common Themes in Mechanisms of Gene Silencing

2001 • 275 citations

CTCF, a Candidate Trans -Acting Factor for X-Inactivation Choice

2002 • 271 citations

The molecular biology of the SIR proteins

2001 • 265 citations

Unravelling heterochromatin: competition between positive and negative factors regulates accessibility

2002 • 259 citations

Cohabitation of insulators and silencing elements in yeast subtelomeric regions

1999 • 239 citations

Modulation of enhancerá¤-promoter interactions by insulators in the Drosophilaembryo

1995 • 226 citations

Polycomb and Trithorax Group Proteins Mediate the Function of a Chromatin Insulator

1998 • 213 citations

Loss of Insulator Activity by Paired Su(Hw) Chromatin Insulators

2001 • 209 citations

The Drosophila melanogaster suppressor of Hairy-wing protein binds to specific sequences of the gypsy retrotransposon.

1988 • 197 citations

Effects of cis Arrangement of Chromatin Insulators on Enhancer-Blocking Activity

2001 • 193 citations

Conserved CTCF Insulator Elements Flank the Mouse and Human β-Globin Loci

2002 • 183 citations

The barrier function of an insulator couples high histone acetylation levels with specific protection of promoter DNA from methylation

2002 • 181 citations

Interactions between the Su(Hw) and Mod(mdg4) proteins required for gypsy insulator function

2001 • 171 citations

Chromatin Insulators and Boundaries: Effects on Transcription and Nuclear Organization

2001 • 162 citations

Promoter-proximal tethering elements regulate enhancer-promoter specificity in the Drosophila Antennapedia complex

2002 • 151 citations

A transcriptional insulator at the imprinted H19/Igf2 locus

2000 • 150 citations

Structural and functional conservation at the boundaries of the chicken β-globin domain

2000 • 149 citations

Insulation of Enhancer-Promoter Communication by a Gypsy Transposon Insert in the Drosophila cut Gene: Cooperation between Suppressor of Hairy-wing and Modifier of mdg4 Proteins

2001 • 134 citations

UASrpg can function as a heterochromatin boundary element in yeast

1999 • 132 citations

Enhancer Blocking by the Drosophila gypsy Insulator Depends Upon Insulator Anatomy and Enhancer Strength

1999 • 125 citations

Effects of the su(Hw) insulator protein on the expression of the divergently transcribed Drosophila yolk protein genes.

1995 • 118 citations

Transcription through theiab-7 cis-regulatory domain of the bithorax complex interferes with maintenance ofPolycomb-mediated silencing

2002 • 113 citations

Regulatory Mechanisms at the MouseIgf2/H19 Locus

2001 • 107 citations

A Differentially Methylated Imprinting Control Region within the Kcnq1 Locus Harbors a Methylation-sensitive Chromatin Insulator

2002 • 95 citations

Transcription defines the embryonic domains of cis-regulatory activity at the Drosophila bithorax complex

2002 • 94 citations

Chip interacts with diverse homeodomain proteins and potentiates Bicoid activity in vivo

2000 • 84 citations

An activation‐independent role of transcription factors in insulator function

2001 • 84 citations

Braking the silence: How heterochromatic gene repression is stopped in its tracks

2002 • 73 citations

The yeastHMLI silencer defines a heterochromatin domain boundary by directional establishment of silencing

1999 • 66 citations

Chromosomal boundaries in S. cerevisiae

2001 • 66 citations

Position effects and genetic disease

1996 • 66 citations

General Regulatory Factors (GRFs) as Genome Partitioners

2002 • 64 citations

Blockers and barriers to transcription: competing activities?

2002 • 63 citations

Protecting against promiscuity: the regulatory role of insulators

2002 • 57 citations

Identification of a multicopy chromatin boundary element at the borders of silenced chromosomal domains

2002 • 54 citations

Regulators split on gene therapy as patient shows signs of cancer

2002 • 53 citations

Coupling of Enhancer and Insulator Properties Identified in Two Retrotransposons Modulates Their Mutagenic Impact on Nearby Genes

2002 • 49 citations

Genomic context modulates insulator activity through promoter competition

2001 • 46 citations

Breaking through to the other side: silencers and barriers

2002 • 42 citations

An evolutionarily conserved putative insulator element near the 3' boundary of the imprinted Igf2/H19 domain

2002 • 38 citations

Domains of Gene Silencing Near the Left End of Chromosome III in Saccharomyces cerevisiae

2002 • 26 citations