Export of the periplasmic maltose-binding protein ofEscherichia coli
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Abstract
References (134)
A new method for predicting signal sequence cleavage sites
1986 • 4,629 citations
Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma.
1975 • 3,026 citations
Patterns of Amino Acids near Signal‐Sequence Cleavage Sites
1983 • 2,290 citations
Signal sequences
1985 • 2,179 citations
Homologous plant and bacterial proteins chaperone oligomeric protein assembly
1988 • 1,316 citations
A putative signal peptidase recognition site and sequence in eukaryotic and prokaryotic signal peptides
1983 • 1,143 citations
Polypeptide chain binding proteins: Catalysts of protein folding and related processes in cells
1989 • 884 citations
The spontaneous insertion of proteins into and across membranes: The helical hairpin hypothesis
1981 • 868 citations
GroE heat-shock proteins promote assembly of foreign prokaryotic ribulose bisphosphate carboxylase oligomers in Escherichia coli
1989 • 703 citations
E. coli mutant pleiotropically defective in the export of secreted proteins
1981 • 512 citations
Mechanism of Protein Translocation Across the Endoplasmic Reticulum Membrane
1986 • 509 citations
Molecular chaperones: proteins essential for the biogenesis of some macromolecular structures
1989 • 491 citations
Protein Translocation Across Membranes
1988 • 482 citations
Correlation of competence for export with lack of tertiary structure of the mature species: A study in vivo of maltose-binding protein in E. coli
1986 • 473 citations
Purification and properties of groE, a host protein involved in bacteriophage assembly
1979 • 426 citations
The Assembly of Proteins into Biological Membranes: The Membrane Trigger Hypothesis
1979 • 408 citations
Secretion and Membrane Localization of Proteins inEscherichia Coli
1980 • 402 citations
Transient association of newly synthesized unfolded proteins with the heat-shock GroEL protein
1988 • 388 citations
Suppressor mutations that restore export of a protein with a defective signal sequence
1981 • 382 citations
Many Random Sequences Functionally Replace the Secretion Signal Sequence of Yeast Invertase
1987 • 375 citations
Protein localization in E. coli: Is there a common step in the secretion of periplasmic and outer-membrane proteins?
1981 • 359 citations
The antifolding activity of SecB promotes the export of the E. coli maltose-binding protein
1988 • 326 citations
Three pure chaperone proteins of Escherichia coli--SecB, trigger factor and GroEL--form soluble complexes with precursor proteins in vitro.
1989 • 317 citations
Leader peptidase catalyzes the release of exported proteins from the outer surface of the Escherichia coli plasma membrane.
1985 • 292 citations
Mechanisms of protein localization
1983 • 282 citations
Sequences of the malE gene and of its product, the maltose-binding protein of Escherichia coli K12.
1984 • 279 citations
Isolation and characterization of the host protein groE involved in bacteriophage lambda assembly
1979 • 272 citations
Evidence for specificity at an early step in protein export in Escherichia coli
1985 • 272 citations
Mutations in a new gene, secB, cause defective protein localization in Escherichia coli
1983 • 270 citations
Mutations which alter the function of the signal sequence of the maltose binding protein of Escherichia coli
1980 • 268 citations
Use of gene fusion to study secretion of maltose-binding protein into Escherichia coli periplasm
1979 • 267 citations
Trigger factor: a soluble protein that folds pro-OmpA into a membrane-assembly-competent form.
1987 • 257 citations
Effects of mutations in heat-shock genes groES and groEL on protein export in Escherichia coli.
1989 • 250 citations
Purified secB protein of Escherichia coli retards folding and promotes membrane translocation of the maltose-binding protein in vitro.
1988 • 243 citations
Modulation of Folding Pathways of Exported Proteins by the Leader Sequence
1988 • 243 citations
Translocation of domains of nascent periplasmic proteins across the cytoplasmic membrane is independent of elongation
1983 • 234 citations
Role of positive charge on the amino-terminal region of the signal peptide in protein secretion across the membrane.
1982 • 234 citations
Unity in Function in the Absence of Consensus in Sequence: Role of Leader Peptides in Export
1989 • 222 citations
Effects of the complete removal of basic amino acid residues from the signal peptide on secretion of lipoprotein in Escherichia coli.
1983 • 214 citations
An artificial anchor domain: hydrophobicity suffices to stop transfer
1985 • 206 citations
Different exported proteins in E. coli show differences in the temporal mode of processing in vivo
1981 • 203 citations
ProOmpA is stabilized for membrane translocation by either purified E. coli trigger factor or canine signal recognition particle
1988 • 196 citations
Protein unfolding and the energetics of protein translocation across biological membranes
1988 • 192 citations
Nucleotide sequence of the secA gene and secA(Ts) mutations preventing protein export in Escherichia coli
1988 • 188 citations
Export of Protein: A Biochemical View
1987 • 184 citations
Synthesis of Exported Proteins by Membrane-Bound Polysomes from Escherichia coli
1977 • 177 citations
In vitro translocation of bacterial proteins across the plasma membrane of Escherichia coli.
1984 • 174 citations
Alteration of the amino terminus of the mature sequence of a periplasmic protein can severely affect protein export in Escherichia coli.
1988 • 163 citations
The “trigger factor cycle” includes ribosomes, presecretory proteins, and the plasma membrane
1988 • 162 citations
Physiological role during export for the retardation of folding by the leader peptide of maltose-binding protein.
1989 • 158 citations
Importance of secondary structure in the signal sequence for protein secretion.
1983 • 152 citations
Procoat, the precursor of M13 coat protein, requires an electrochemical potential for membrane insertion.
1980 • 149 citations
A signal sequence is not sufficient to lead β-galactosidase out of the cytoplasm
1980 • 149 citations
Use of gene fusions to study outer membrane protein localization in Escherichia coli.
1977 • 148 citations
ProOmpA spontaneously folds in a membrane assembly competent state which trigger factor stabilizes.
1988 • 135 citations
Positive charges at the NH2 terminus convert the membrane-anchor signal peptide of cytochrome P-450 to a secretory signal peptide.
1988 • 135 citations
Identification of a new gene (secA) and gene product involved in the secretion of envelope proteins in Escherichia coli
1982 • 134 citations
In vitro translocation of protein across Escherichia coli membrane vesicles requires both the proton motive force and ATP.
1987 • 130 citations
In Vivo Function and Membrane Binding Properties Are Correlated for Escherichia coli lamB Signal Peptides
1985 • 130 citations
Escherichia coli mutants accumulating the precursor of a secreted protein in the cytoplasm
1979 • 129 citations
Localization and processing of outer membrane and periplasmic proteins in Escherichia coli strains harboring export-specific suppressor mutations.
1982 • 124 citations
Precursors of three exported proteins in Escherichia coli.
1978 • 123 citations
Escherichia coli SecB protein associates with exported protein precursors in vivo.
1989 • 123 citations
Positively charged amino acid residues can act as topogenic determinants in membrane proteins.
1989 • 122 citations
Identification of the secY (prlA) gene product involved in protein export in Escherichia coli
1984 • 119 citations
Effects of Escherichia coli secB mutations on pre-maltose binding protein conformation and export kinetics.
1988 • 117 citations
Use of phoA fusions to study the topology of the Escherichia coli inner membrane protein leader peptidase
1989 • 111 citations
Intragenic suppressor mutations that restore export of maltose binding protein with a truncated signal peptide
1984 • 111 citations
Kinetic analysis of lamB mutants suggests the signal sequence plays multiple roles in protein export.
1986 • 107 citations
SecB functions as a cytosolic signal recognition factor for protein export in E. coli
1989 • 107 citations
Specific recognition of the leader region of precursor proteins is required for the activation of translocation ATPase of Escherichia coli.
1989 • 107 citations
Export of unprocessed precursor maltose-binding protein to the periplasm of Escherichia coli cells
1987 • 106 citations
Identification of a host protein necessary for bacteriophage morphogenesis (the groE gene product).
1978 • 103 citations
Mechanisms of protein localization.
1983 • 100 citations
Maturation of Escherichia coli maltose-binding protein by signal peptidase I in vivo. Sequence requirements for efficient processing and demonstration of an alternate cleavage site.
1990 • 100 citations
Novel secA alleles improve export of maltose-binding protein synthesized with a defective signal peptide
1989 • 99 citations
Signal peptide amino acid sequences in Escherichia coli contain information related to final protein localization. A multivariate data analysis.
1987 • 99 citations
Alkaline phosphatase and OmpA protein can be translocated posttranslationally into membrane vesicles of Escherichia coli
1985 • 98 citations
Idealization of the hydrophobic segment of the alkaline phosphatase signal peptide
1986 • 98 citations
The mature portion of Escherichia coli maltose-binding protein (MBP) determines the dependence of MBP on SecB for export
1989 • 97 citations
Retardation of folding as a possible means of suppression of a mutation in the leader sequence of an exported protein.
1988 • 95 citations
Genetic studies on the inability of beta-galactosidase to be translocated across the Escherichia coli cytoplasmic membrane
1989 • 90 citations
Conserved residues of the leader peptide are essential for cleavage by leader peptidase.
1985 • 90 citations
Soluble precursor of an integral membrane protein: synthesis of procoat protein in Escherichia coli infected with bacteriophage M13.
1979 • 85 citations
Effects of signal sequence mutations on the kinetics of alkaline phosphatase export to the periplasm in Escherichia coli
1986 • 85 citations
Cytosolic factor purified from Escherichia coli is necessary and sufficient for the export of a preprotein and is a homotetramer of SecB.
1989 • 83 citations
New suppressors of signal-sequence mutations, prlG, are linked tightly to the secE gene of Escherichia coli.
1989 • 80 citations
Chapter 2 Structure and Function of the Signal Peptide
1985 • 80 citations
Isolation and partial characterization of membrane vesicles carrying markers of the membrane adhesion sites
1982 • 79 citations
Analysis of mutational alterations in the hydrophilic segment of the maltose-binding protein signal peptide
1989 • 79 citations
Evidence for a coupling of synthesis and export of an outer membrane protein in Escherichia coli.
1983 • 78 citations
Energy-requiring translocation of the OmpA protein and alkaline phosphatase of Escherichia coli into inner membrane vesicles
1984 • 74 citations
Proper interaction between at least two components is required for efficient export of proteins to the Escherichia coli cell envelope
1985 • 74 citations
The synthesis of export-defective proteins can interfere with normal protein export in Escherichia coli.
1984 • 73 citations
Processing in vivo of precursor maltose-binding protein in Escherichia coli occurs post-translationally as well as co-translationally.
1981 • 73 citations
Role of the leader peptide of maltose-binding protein in two steps of the export process
1988 • 72 citations
Intragenic regions required for LamB export.
1984 • 70 citations
Role of the mature protein sequence of maltose-binding protein in its secretion across the E. coli cytoplasmic membrane
1981 • 69 citations
Role of amino-terminal positive charge on signal peptide in staphylokinase export across the cytoplasmic membrane of Escherichia coli.
1987 • 69 citations
A conservative amino acid substitution, arginine for lysine, abolishes export of a hybrid protein in Escherichia coli
1989 • 69 citations
Characterization of the Escherichia coli protein-export gene secB
1989 • 69 citations
Illicit secretion of a cytoplasmic protein into the periplasm of Escherichia coli requires a signal peptide plus a portion of the cognate secreted protein
1989 • 66 citations
Post-translational export of maltose-binding protein in Escherichia coli strains harboring malE signal sequence mutations and either prl+ or prl suppressor alleles.
1985 • 63 citations
Preprotein conformation: the year's major theme in translocation studies
1988 • 63 citations
The cytoplasmic domain of Escherichia coli leader peptidase is a "translocation poison" sequence.
1988 • 61 citations
Sequence information required for protein translocation from the cytoplasm
1987 • 58 citations
Localization of Polyribosomes Containing Alkaline Phosphatase Nascent Polypeptides on Membranes of Escherichia coli
1974 • 55 citations
Suppression of a signal sequence mutation by an amino acid substitution in the mature portion of the maltose-binding protein
1987 • 54 citations
Mutations that affect lamB gene expression at a posttranscriptional level.
1981 • 53 citations
Intragenic reversion mutations that improve export of maltose-binding protein in Escherichia coli malE signal sequence mutants.
1986 • 51 citations
Chapter 3 The Use of Genetic Techniques to Analyze Protein Export in Escherichia coli
1985 • 50 citations
PrlA is important for the translocation of exported proteins across the cytoplasmic membrane of Escherichia coli.
1989 • 50 citations
The secY protein can act post-translationally to promote bacterial protein export.
1986 • 50 citations
Active transport of maltose in membrane vesicles obtained from Escherichia coli cells producing tethered maltose-binding protein
1989 • 46 citations
The first 28 amino acids of mature LamB are required for rapid and efficient export from the cytoplasm.
1987 • 45 citations
The role of the positively charged N-terminus of the signal sequence of E. coli outer membrane protein PhoE in export
1989 • 44 citations
Conformational properties of <scp>L</scp>‐leucine, <scp>L</scp>‐isoleucine, and <scp>L</scp>‐norleucine side chains in <scp>L</scp>‐lysine copolymers
1977 • 42 citations
A functional decaisoleucine-containing signal sequence. Construction by cassette mutagenesis.
1988 • 41 citations
Membrane assembly: Posttranslational insertion of M13 procoat protein into E. coli membranes and its proteolytic conversion to coat protein in vitro
1981 • 40 citations
In vivo and in vitro synthesis of Escherichia coli maltose-binding protein under regulatory control of the lacUV5 promoter-operator
1985 • 38 citations
Mutational alterations affecting the export competence of a truncated but fully functional maltose-binding protein signal peptide
1987 • 38 citations
Mutations that improve export of maltose-binding protein in SecB- cells of Escherichia coli
1989 • 37 citations
Cytosolic protein translocation factors is SRP still unique?
1989 • 36 citations
Export and processing of MalE-LacZ hybrid proteins in Escherichia coli
1984 • 35 citations
Factors influencing the in vitro translocation of the Escherichia coli maltose-binding protein
1989 • 30 citations
Dihydrofolate reductase (mouse) and beta-galactosidase (Escherichia coli) can be translocated across the plasma membrane of E. coli.
1988 • 29 citations
The leader region of pre-maltose binding protein binds amphiphiles. A model for self-assembly in protein export.
1985 • 28 citations
Binding of a soluble factor of Escherichia coli to preproteins does not require ATP and appears to be the first step in protein export.
1989 • 20 citations
Precursor maltose-binding protein is active in binding substrate.
1979 • 19 citations
Inhibition and resumption of processing of the staphylokinase in some Escherichia coli prlA suppressor mutants.
1988 • 18 citations
Membrane transport and neuroreceptors
1982 • 18 citations
Insertion of a MalE β-Galactosidase Fusion Protein into the Envelope of Escherichia coli Disrupts Biogenesis of Outer Membrane Proteins and Processing of Inner Membrane Proteins
1982 • 17 citations
Both linked and unlinked mutations can alter the intracellular site of synthesis of exported proteins of Escherichia coli
1985 • 16 citations
Analysis of ribosomes engaged in the synthesis of the outer membrane protein of Escherichia coli
1975 • 13 citations