Interleukin-6, a new target for therapy in multiple myeloma?

Interleukin-6 and the acute phase response

1990 • 2,740 citations

Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin

1986 • 2,137 citations

The biology of interleukin-6

1989 • 1,964 citations

Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas

1988 • 1,698 citations

The biology of interleukin-6

1989 • 1,459 citations

The essential role of B cell stimulatory factor 2 (BSF-2/IL-6) for the terminal differentiation of B cells.

1988 • 791 citations

Paracrine rather than autocrine regulation of myeloma-cell growth and differentiation by interleukin-6

1989 • 775 citations

Identification of the human 26-kD protein, interferon beta 2 (IFN-beta 2), as a B cell hybridoma/plasmacytoma growth factor induced by interleukin 1 and tumor necrosis factor.

1987 • 690 citations

IgG1 plasmacytosis in interleukin 6 transgenic mice.

1989 • 597 citations

Serum levels of interleukin 6, a potent myeloma cell growth factor, as a reflect of disease severity in plasma cell dyscrasias.

1989 • 501 citations

IL-6 stimulates osteoclast-like multinucleated cell formation in long term human marrow cultures by inducing IL-1 release.

1990 • 493 citations

Murine anti-interleukin-6 monoclonal antibody therapy for a patient with plasma cell leukemia

1991 • 419 citations

A Macrophage-Derived Factor Required by Plasmacytomas for Survival and Proliferation in Vitro

1986 • 391 citations

Allogeneic Bone Marrow Transplantation in Multiple Myeloma

1991 • 389 citations

Complex of soluble human IL-6-receptor/IL-6 up-regulates expression of acute-phase proteins.

1992 • 373 citations

High-dose melphalan with autologous bone marrow transplantation for multiple myeloma

1986 • 336 citations

Induction of Plasma-Cell Neoplasms in Strain BALB/c Mice with Mineral Oil and Mineral Oil Adjuvants

1962 • 311 citations

C-reactive protein and beta-2 microglobulin produce a simple and powerful myeloma staging system

1992 • 296 citations

cDNA cloning of murine interleukin-HP1: homology with human interleukin 6

1988 • 292 citations

Monocyte-Derived Human B-Cell Growth Factor Identified as Interferon-β ₂ (BSF-2, IL-6)

1988 • 281 citations

Interleukin-6 is a potent myeloma-cell growth factor in patients with aggressive multiple myeloma

1989 • 271 citations

Multiple myeloma treated with high dose intravenous melphalan

1987 • 251 citations

Generation of plasmacytomas with the chromosomal translocation t(12;15) in interleukin 6 transgenic mice.

1992 • 234 citations

Response patterns of purified myeloma cells to hematopoietic growth factors

1989 • 231 citations

'Role of bone marrow stromal cells in the growth of human multiple myeloma

1991 • 223 citations

'Role of bone marrow stromal cells in the growth of human multiple myeloma

1991 • 194 citations

Interleukin 3 and interleukin 6 synergistically promote the proliferation and differentiation of malignant plasma cell precursors in multiple myeloma.

1989 • 163 citations

The role of interleukin‐1 and tumour necrosis factor‐α in human multiple myeloma

1990 • 151 citations

Cytokine Network in Human Multiple Myeloma

1992 • 150 citations

Purification and NH2-terminal sequence of a plasmacytoma growth factor derived from the murine macrophage cell line P388D1.

1987 • 145 citations

Interleukin-1 accelerates autocrine growth of myeloma cells through interleukin-6 in human myeloma

1989 • 141 citations

Serum levels of interleukin-6 in multiple myeloma and other hematological disorders: correlation with disease activity and other prognostic parameters

1991 • 139 citations

Granulocyte-macrophage colony-stimulating factor synergizes with interleukin-6 in supporting the proliferation of human myeloma cells [see comments]

1990 • 125 citations

Interleukin-6 is the central tumor growth factor in vitro and in vivo in multiple myeloma.

1990 • 124 citations

Mouse plasmacytoma growth in vivo: enhancement by interleukin 6 (IL-6) and inhibition by antibodies directed against IL-6 or its receptor.

1990 • 121 citations

High-dose melphalan with autologous bone marrow transplantation for multiple myeloma

1986 • 119 citations

Mechanisms of Bone Lesions in Multiple Myeloma

1992 • 116 citations

Establishment of two interleukin 6 (B cell stimulatory factor 2/interferon beta 2)-dependent human bone marrow-derived myeloma cell lines.

1989 • 107 citations

Management of refractory myeloma: a review.

1988 • 106 citations

Expression of an exogenous interleukin 6 gene in human Epstein Barr virus B cells confers growth advantage and in vivo tumorigenicity.

1990 • 105 citations

IFN-alpha induces autocrine production of IL-6 in myeloma cell lines.

1991 • 105 citations

Interleukin-4 induces secretion of CSF for granulocytes and CSF for macrophages by peripheral blood monocytes

1989 • 103 citations

Anti‐human interleukin‐6 receptor antibody inhibits human myeloma growth in vivo

1992 • 99 citations

In vivo interleukin 6 gene expression in the tumoral environment in multiple myeloma

1991 • 91 citations

Chemotherapy of previously untreated multiple myeloma patients: an analysis of recent treatment results.

1986 • 83 citations

Growth autonomy and tumorigenicity of interleukin 6-dependent B cells transfected with interleukin 6 cDNA.

1990 • 71 citations

Interleukin-4 inhibits growth of multiple myelomas by suppressing interleukin-6 expression.

1991 • 65 citations

Prognostic factors with high-dose melphalan for refractory multiple myeloma [see comments]

1988 • 62 citations

Stimulation of EBV-activated human B cells by monocytes and monocyte products. Role of IFN-beta 2/B cell stimulatory factor 2/IL-6.

1988 • 62 citations

Glucocorticosteroid‐dependent synergy between interleukin 1 and interleukin 6 for human B lymphocyte differentiation

1988 • 59 citations

Interleukin-4 inhibits growth of multiple myelomas by suppressing interleukin-6 expression

1991 • 54 citations

Monocyte-derived human B-cell growth factor identified as interferon-beta 2 (BSF-2, IL-6)

1988 • 51 citations

Expression of a novel 3.5-kb macrophage colony-stimulating factor transcript in human myeloma cells.

1989 • 49 citations

Increase in interleukin 6 (IL-6) and IL-6 receptor expression in a human multiple myeloma cell line, U-266, during long-term in vitro culture and the development of a possible autocrine IL-6 loop.

1992 • 46 citations

Recombinant interferon‐ γ inhibits the growth of IL‐6‐dependent human multiple myeloma cell lines in vitro

1991 • 46 citations

Interleukin 6 dependence of spontaneous in vitro differentiation of B cells from patients with IgM gammapathy.

1990 • 44 citations

Interleukin-6 fused to a mutant form of Pseudomonas exotoxin kills malignant cells from patients with multiple myeloma

1992 • 42 citations

BSF‐2/IL‐6 does not augment lg secretion but stimulates proliferation in myeloma cells

1989 • 37 citations

Prognostic factors with high-dose melphalan for refractory multiple myeloma [see comments]

1988 • 36 citations

Interleukin-6 enhances human Ig production, but not as a terminal differentiation factor for B lymphocytes

1990 • 9 citations

Monoclonal gammapathies III: clinical significance and basic mechanisms: proceedings of the third Eurage symposium, Brussels, September 19-20, 1991

1991 • 1 citations