Growth autonomy and tumorigenicity of interleukin 6-dependent B cells transfected with interleukin 6 cDNA.

A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation

1986 • 4,200 citations

Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin

1986 • 2,137 citations

A New Mouse Myeloma Cell Line that Has Lost Immunoglobulin Expression but Permits the Construction of Antibody-Secreting Hybrid Cell Lines

1979 • 1,885 citations

Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas

1988 • 1,698 citations

Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells.

1987 • 1,667 citations

Identification of a common nucleotide sequence in the 3'-untranslated region of mRNA molecules specifying inflammatory mediators.

1986 • 1,591 citations

Simian Sarcoma Virus onc Gene, v- sis , Is Derived from the Gene (or Genes) Encoding a Platelet-Derived Growth Factor

1983 • 1,550 citations

Autocrine growth factors and cancer

1985 • 1,462 citations

Growth factors from murine sarcoma virus-transformed cells.

1978 • 1,457 citations

Autocrine Secretion and Malignant Transformation of Cells

1980 • 1,370 citations

Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors

1988 • 1,086 citations

Interleukin 6 enhancement of interleukin 3-dependent proliferation of multipotential hemopoietic progenitors.

1987 • 847 citations

The essential role of B cell stimulatory factor 2 (BSF-2/IL-6) for the terminal differentiation of B cells.

1988 • 791 citations

Paracrine rather than autocrine regulation of myeloma-cell growth and differentiation by interleukin-6

1989 • 775 citations

Purification and NH2-terminal amino acid sequence of a T-cell-derived lymphokine with growth factor activity for B-cell hybridomas.

1986 • 701 citations

Identification of the human 26-kD protein, interferon beta 2 (IFN-beta 2), as a B cell hybridoma/plasmacytoma growth factor induced by interleukin 1 and tumor necrosis factor.

1987 • 690 citations

Molecular Regulation of B Lymphocyte Response

1988 • 579 citations

B cell stimulating factor 2/interleukin 6 is a costimulant for human thymocytes and T lymphocytes.

1988 • 537 citations

Multiple actions of interleukin 6 within a cytokine network

1988 • 536 citations

A Macrophage-Derived Factor Required by Plasmacytomas for Survival and Proliferation in Vitro

1986 • 391 citations

B cell stimulatory factor-2 is involved in the differentiation of cytotoxic T lymphocytes.

1988 • 382 citations

Human B-cell differentiation factor defined by an anti-peptide antibody and its possible role in autoantibody production.

1987 • 363 citations

B-cell-stimulatory factor 2 (beta 2 interferon) functions as a second signal for interleukin 2 production by mature murine T cells.

1987 • 357 citations

Structural analysis of the sequence coding for an inducible 26‐kDa protein in human fibroblasts

1986 • 343 citations

Human cutaneous T cell lymphoma and leukemia cell lines produce and respond to T cell growth factor

1981 • 340 citations

Induction of Plasma-Cell Neoplasms in Strain BALB/c Mice with Mineral Oil and Mineral Oil Adjuvants

1962 • 311 citations

cDNA cloning of murine interleukin-HP1: homology with human interleukin 6

1988 • 292 citations

Direct transfer of cloned genes from bacteria to mammalian cells.

1980 • 291 citations

Monocyte-Derived Human B-Cell Growth Factor Identified as Interferon-β ₂ (BSF-2, IL-6)

1988 • 281 citations

T cell growth and differentiation induced by interleukin-HP1/IL-6, the murine hybridoma/plasmacytoma growth factor.

1988 • 244 citations

B cell growth modulating and differentiating activity of recombinant human 26-kd protein (BSF-2, HuIFN-beta 2, HPGF).

1987 • 220 citations

Transforming growth factor(s) production enables cells to grow in the absence of serum: an autocrine system.

1982 • 219 citations

Interleukin-HP1, a T cell-derived hybridoma growth factor that supports the in vitro growth of murine plasmacytomas.

1987 • 174 citations

Purification and NH2-terminal sequence of a plasmacytoma growth factor derived from the murine macrophage cell line P388D1.

1987 • 145 citations

Autocrine growth and tumorigenicity of interleukin 2-dependent helper T cells transfected with IL-2 gene.

1989 • 141 citations

Autocrine growth of interleukin 2-producing leukemic cells in a patient with adult T cell leukemia

1986 • 98 citations

Autocrine growth stimulation of a human T-cell lymphoma line by interleukin 2.

1985 • 86 citations

The Synergism of Aecessory Cells and of Soluble a‐Factors Derived from Them in the Activation of B Cells to Proliferation

1984 • 78 citations

Decrease in BSF-2/IL-6 response in advanced cases of multiple myeloma

1988 • 59 citations

Molecular Regulation Of B Lymphocyte Response

1988 • 45 citations

A case of human B cell leukemia that implicates an autocrine mechanism in the abnormal growth of Leu 1 B cells.

1986 • 34 citations

Autocrine production of pre-B-cell stimulating activity by a variety of transformed murine pre-B-cell lines.

1988 • 12 citations

Autocrine growth of interleukin 2-producing leukemic cells in a patient with adult T cell leukemia

1986 • 10 citations

Decrease in BSF-2/IL-6 response in advanced cases of multiple myeloma

1988 • 5 citations