Mechanisms of Bone Lesions in Multiple Myeloma

Origin of osteoclasts: mature monocytes and macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-derived stromal cells.

1990 • 1,028 citations

Total absence of colony-stimulating factor 1 in the macrophage-deficient osteopetrotic (op/op) mouse.

1990 • 1,012 citations

Paracrine rather than autocrine regulation of myeloma-cell growth and differentiation by interleukin-6

1989 • 775 citations

Evidence for the Secretion of an Osteoclast Stimulating Factor in Myeloma

1974 • 681 citations

Growth factors and the regulation of bone remodeling.

1988 • 614 citations

Serum levels of interleukin 6, a potent myeloma cell growth factor, as a reflect of disease severity in plasma cell dyscrasias.

1989 • 501 citations

Murine anti-interleukin-6 monoclonal antibody therapy for a patient with plasma cell leukemia

1991 • 419 citations

Macrophage growth factor CSF-1 stimulates human monocyte production of interferon, tumor necrosis factor, and colony stimulating activity.

1986 • 397 citations

Production of Lymphotoxin, a Bone-Resorbing Cytokine, by Cultured Human Myeloma Cells

1987 • 386 citations

Interleukin-6 is a potent myeloma-cell growth factor in patients with aggressive multiple myeloma

1989 • 271 citations

Recruitment of new osteoblasts and osteoclasts is the earliest critical event in the pathogenesis of human multiple myeloma.

1991 • 256 citations

Mechanisms of bone destruction in multiple myeloma: the importance of an unbalanced process in determining the severity of lytic bone disease.

1989 • 240 citations

Effects of human recombinant CSF-GM and highly purified CSF-1 on the formation of multinucleated cells with osteoclast characteristics in long-term bone marrow cultures

1986 • 215 citations

'Role of bone marrow stromal cells in the growth of human multiple myeloma

1991 • 194 citations

Production of interleukin-1 by bone marrow myeloma cells

1989 • 191 citations

Effects of Dichloromethylene Diphosphonate on Skeletal Mobilization of Calcium in Multiple Myeloma

1980 • 186 citations

Quantitative histology of myeloma‐induced bone changes

1982 • 183 citations

IFN-beta 2/IL-6 augments the activity of human natural killer cells.

1989 • 150 citations

Long-Term Effects of Dichloromethylene Diphosphonate (Cl2 DP) on skeletal Lesions in Multiple Myeloma

1982 • 126 citations

Interleukin-1 beta rather than lymphotoxin as the major bone resorbing activity in human multiple myeloma

1989 • 126 citations

Granulocyte-macrophage colony-stimulating factor synergizes with interleukin-6 in supporting the proliferation of human myeloma cells [see comments]

1990 • 125 citations

Evidence that tumor necrosis factor plays a pathogenetic role in the paraneoplastic syndromes of cachexia, hypercalcemia, and leukocytosis in a human tumor in nude mice.

1991 • 123 citations

Relation of Osteoclast Activating Factor Production to Extent of Bone Disease in Multiple Myeloma

1981 • 122 citations

Interleukin-6 synergizes with M-CSF in the formation of macrophage colonies from purified human marrow progenitor cells

1989 • 98 citations

Increased circulating colony-stimulating factor-1 in patients with preleukemia, leukemia, and lymphoid malignancies

1991 • 97 citations

In vivo interleukin 6 gene expression in the tumoral environment in multiple myeloma

1991 • 91 citations

Abnormal serum bone gla protein levels in multiple myeloma: Crucial role of bone formation and prognostic implications

1990 • 85 citations

Influence of treatment with APD-bisphosphonate on the bone lesions in the mouse 5T2 multiple myeloma

1985 • 80 citations

The use of dichloromethylene diphosphonate for the management of hypercalcaemia in multiple myeloma

1983 • 79 citations

Serum bone gla-protein in multiple myeloma

1987 • 70 citations

Osteoblast stimulation in multiple myeloma lacking lytic bone lesions

1990 • 60 citations

Importance of quantitative histology of bone changes in monoclonal gammopathy

1986 • 57 citations

Strong natural killer (NK) cell activity in bone marrow of myeloma patients: Accelerated maturation of bone marrow NK cells and their interaction with other bone marrow cells

1984 • 57 citations

B cell malignancies presenting with unusual bone involvement and mimicking multiple myeloma

1987 • 56 citations

Expression of a novel 3.5-kb macrophage colony-stimulating factor transcript in human myeloma cells.

1989 • 49 citations

Histologic evidence of an abnormal bone remodeling in b-cell malignancies other than multiple myeloma

1988 • 47 citations

Observations on the Mechanism of Bone Resorption Induced by Multiple Myeloma Marrow Culture Fluids and Partially Purified Osteoclast-activating Factor

1981 • 46 citations

Micro‐osteoclast resorption as a characteristic feature of B‐cell malignancies other than multiple myeloma

1990 • 40 citations

Comparison of the effect of IL-2 and IL-6 on the lytic activity of purified human peripheral blood large granular lymphocytes.

1991 • 39 citations

Bone Healing in Multiple Myeloma with Melphalan Chemotherapy

1972 • 36 citations

The many facets of multiple myeloma

1974 • 32 citations

Osteoclast cytomorphometry demonstrates an abnormal population in B cell malignancies but not in multiple myeloma

1991 • 31 citations

Treatment of painful bone lesions and hypercalcemia

1989 • 25 citations

Clinical evaluation of myeloma osteoclastic bone lesions: II. Induced hypocalcemia test using salmon calcitonin

1982 • 23 citations

Controlled environment culture of bone marrow explants from human myeloma.

1976 • 18 citations

In vitro osteolytic activity of human myeloma plasma cells and the clinical evaluation of myeloma osteoclastic bone lesions

1984 • 15 citations

Acute effects of salmon calcitonin in multiple myeloma: a valuable method for serial evaluation of osteoclastic lesions and disease activity--a prospective study of 125 patients.

1985 • 14 citations