Upstream Elements Present in the 3′-Untranslated Region of Collagen Genes Influence the Processing Efficiency of Overlapping Polyadenylation Signals

Integrating mRNA Processing with Transcription

2002 • 1,054 citations

Formation of mRNA 3′ Ends in Eukaryotes: Mechanism, Regulation, and Interrelationships with Other Steps in mRNA Synthesis

1999 • 1,016 citations

Mechanism and regulation of mRNA polyadenylation

1997 • 762 citations

Starting at the Beginning, Middle, and End: Translation Initiation in Eukaryotes

1997 • 685 citations

INTERRELATIONSHIPS OF THE PATHWAYS OF mRNA DECAY AND TRANSLATION IN EUKARYOTIC CELLS

1996 • 653 citations

Alternative poly(A) site selection in complex transcription units: means to an end?

1997 • 508 citations

The Polyadenylation Factor CstF-64 Regulates Alternative Processing of IgM Heavy Chain Pre-mRNA during B Cell Differentiation

1996 • 416 citations

The ends of the affair: capping and polyadenylation.

2000 • 340 citations

Quantitative analysis of gene expression in human articular cartilage from normal and osteoarthritic joints

2001 • 338 citations

Life and death in the cytoplasm: messages from the 3′ end

1997 • 335 citations

In silico detection of control signals: mRNA 3′-end-processing sequences in diverse species

1999 • 230 citations

Regulation of Alternative Polyadenylation by U1 snRNPs and SRp20

1998 • 186 citations

Cleavage site determinants min the mammalian polydenylation signal

1995 • 186 citations

Connecting transcription to messenger RNA processing

2000 • 182 citations

PATHOGENESIS OF SCLERODERMA

1996 • 178 citations

Interaction between the U1 snRNP-A protein and the 160-kD subunit of cleavage-polyadenylation specificity factor increases polyadenylation efficiency in vitro.

1996 • 167 citations

Sequences 5' to the polyadenylation signal mediate differential poly(A) site use in hepatitis B viruses.

1990 • 159 citations

Analysis of the 3' end of the human pro-alpha 2(I) collagen gene. Utilization of multiple polyadenylation sites in cultured fibroblasts.

1983 • 158 citations

Organization of the human pro-alpha 2(I) collagen gene.

1987 • 156 citations

The upstream sequence element of the C2 complement poly(A) signal activates mRNA 3′ end formation by two distinct mechanisms

1998 • 156 citations

Direct interaction of the U1 snRNP-A protein with the upstream efficiency element of the SV40 late polyadenylation signal.

1994 • 146 citations

Mouse type II collagen gene. Complete nucleotide sequence, exon structure, and alternative splicing.

1991 • 144 citations

The human immunodeficiency virus type 1 polyadenylylation signal: a 3' long terminal repeat element upstream of the AAUAAA necessary for efficient polyadenylylation.

1991 • 136 citations

CPSF recognition of an HIV-1 mRNA 3'-processing enhancer: multiple sequence contacts involved in poly(A) site definition.

1995 • 128 citations

A comparison of mammalian and yeast pre-mRNA 3′-end processing

1997 • 122 citations

Sequences upstream of AAUAAA influence poly(A) site selection in a complex transcription unit.

1989 • 108 citations

A dissection of the cauliflower mosaic virus polyadenylation signal.

1991 • 105 citations

Downstream sequence elements with different affinities for the hnRNP H/H' protein influence the processing efficiency of mammalian polyadenylation signals

2002 • 99 citations

Ending the Message Is Not So Simple

1996 • 92 citations

Efficient polyadenylation within the human immunodeficiency virus type 1 long terminal repeat requires flanking U3-specific sequences

1991 • 90 citations

Upstream sequence elements enhance poly(A) site efficiency of the C2 complement gene and are phylogenetically conserved.

1995 • 89 citations

Modification of the megaprimer method of PCR mutagenesis: improved amplification of the final product.

1993 • 88 citations

Activation of HIV-1 pre-mRNA 3′ processing in vitro requires both an upstream element and TAR.

1992 • 87 citations

The C proteins of heterogeneous nuclear ribonucleoprotein complexes interact with RNA sequences downstream of polyadenylation cleavage sites.

1988 • 86 citations

Increase in the 64-kDa subunit of the polyadenylation/cleavage stimulatory factor during the G₀to S phase transition

1998 • 85 citations

Unstable molecules form stable tissues

2002 • 85 citations

Definition of the Upstream Efficiency Element of the Simian Virus 40 Late Polyadenylation Signal by Using In Vitro Analyses

1992 • 81 citations

Involvement of long terminal repeat U3 sequences overlapping the transcription control region in human immunodeficiency virus type 1 mRNA 3' end formation.

1991 • 79 citations

EM Visualization of Transcription by RNA Polymerase II

1999 • 77 citations

Structure and sequence of the chicken type II procollagen gene. Characterization of the region encoding the carboxyl-terminal telopeptide and propeptide.

1984 • 76 citations

Elements upstream of the AAUAAA within the human immunodeficiency virus polyadenylation signal are required for efficient polyadenylation in vitro.

1992 • 73 citations

3' RNA processing efficiency plays a primary role in generating termination-competent RNA polymerase II elongation complexes.

1993 • 71 citations

The influence of 5′ and 3′ end structures on pre-mRNA metabolism

1995 • 68 citations

Sequence and position requirements for uridylate-rich downstream elements of polyadenylation signals

1994 • 64 citations

Assessment of specific mRNA levels in cartilage regions in a lapine model of osteoarthritis

2002 • 62 citations

Regulation of polyadenylation in hepatitis B viruses: stimulation by the upstream activating signal PS1 is orientation-dependent, distance-independent, and additive

1991 • 59 citations

Structure of the carboxyl propeptide of chicken type II procollagen determined by DNA and protein sequence analysis

1984 • 56 citations

Auxiliary downstream elements are required for efficient polyadenylation of mammalian pre-mRNAs

1998 • 54 citations

Patterns of polyadenylation site selection in gene constructs containing multiple polyadenylation signals.

1988 • 53 citations

Determination of the single polyadenylation site of the human proα1(II) collagen gene

1987 • 48 citations

Comparison of Northern blot hybridization and a reverse transcriptase-polymerase chain reaction technique for measurement of mRNA expression of metalloproteinases and matrix components in articular cartilage and synovial membrane from horses with osteoarthritis

2000 • 48 citations

Assembly of the Cleavage and Polyadenylation Apparatus Requires About 10 Seconds In Vivo and Is Faster for Strong than for Weak Poly(A) Sites

1999 • 45 citations

The snRNP-free U1A (SF-A) complex(es): Identification of the largest subunit as PSF, the polypyrimidine-tract binding protein-associated splicing factor

1998 • 45 citations

Sequence elements upstream of the 3' cleavage site confer substrate strength to the adenovirus L1 and L3 polyadenylation sites.

1994 • 40 citations

Analysis of cDNA and genomic clones coding for the proα1 chain of calf Type II collagen

1985 • 37 citations

Transcription and polyadenylation in a short human intergenic region

1997 • 37 citations

Highly conserved sequences in the 3′‐untranslated region of the COL1A1 gene bind cell‐specific nuclear proteins

1991 • 27 citations

Structure of the Type II Collagen Genea

1985 • 22 citations

Demonstration of increased levels of type I collagen mRNA using quantitative polymerase chain reaction in fibrotic and granulomatous skin diseases

1998 • 16 citations

Preparation of mammalian extracts active in polyadenylation

1990 • 15 citations