Amino acids 356–372 constitute a G_i‐activator sequence of the α₂‐adrenergic receptor and have a Phe substitute in the G protein‐activator sequence motif

G Proteins: A Family of Signal Transducers

1986 • 975 citations

Cloning, Sequencing, and Expression of the Gene Coding for the Human Platelet α ₂ -Adrenergic Receptor

1987 • 792 citations

Chimeric α ₂ -,β ₂ -Adrenergic Receptors: Delineation of Domains Involved in Effector Coupling and Ligand Binding Specificity

1988 • 766 citations

Hormonal stimulation of adenylyl cyclase through Gi-protein βγ subunits

1992 • 623 citations

Site-directed mutagenesis of the cytoplasmic domains of the human beta 2-adrenergic receptor. Localization of regions involved in G protein-receptor coupling.

1988 • 400 citations

Encyclopedia of human biology

1991 • 396 citations

Rhodopsin Mutants That Bind But Fail to Activate Transducin

1990 • 377 citations

Three cytoplasmic loops of rhodopsin interact with transducin.

1989 • 370 citations

Simultaneous coupling of alpha 2-adrenergic receptors to two G-proteins with opposing effects. Subtype-selective coupling of alpha 2C10, alpha 2C4, and alpha 2C2 adrenergic receptors to Gi and Gs.

1992 • 319 citations

A simple structure encodes G protein-activating function of the IGF-II/mannose 6-phosphate receptor

1990 • 278 citations

Identification of a Gs activator region of the β2-adrenergic receptor that is autoregulated via protein kinase A-dependent phosphorylation

1991 • 273 citations

Mutations that uncouple the beta-adrenergic receptor from Gs and increase agonist affinity.

1987 • 259 citations

Chimeric muscarinic cholinergic: beta-adrenergic receptors that activate Gs in response to muscarinic agonists.

1990 • 230 citations

Detection of G protein-activator regions in M4 subtype muscarinic, cholinergic, and alpha 2-adrenergic receptors based upon characteristics in primary structure.

1992 • 201 citations

Functional reconstitution of the alpha 2-adrenergic receptor with guanine nucleotide regulatory proteins in phospholipid vesicles.

1986 • 199 citations

A new GTP‐binding protein in brain tissues serving as the specific substrate of islet‐activating protein, pertussis toxin

1987 • 189 citations

Possible Direct Linkage of Insulin-like Growth Factor-II Receptor with Guanine Nucleotide-binding Proteins

1989 • 169 citations

Location of a region of the muscarinic acetylcholine receptor involved in selective effector coupling

1988 • 167 citations

Light-induced binding of guanosinetriphosphatase to bovine photoreceptor membranes: effect of limited proteolysis of the membranes

1981 • 136 citations

Cloning, sequencing, and expression of the gene encoding the porcine alpha 2-adrenergic receptor. Allosteric modulation by Na+, H+, and amiloride analogs.

1990 • 117 citations

Distinctive regulation of the functional linkage between the human cation-independent mannose 6-phosphate receptor and GTP-binding proteins by insulin-like growth factor II and mannose 6-phosphate.

1990 • 108 citations

Mapping sites of interaction between rhodopsin and transducin using rhodopsin antipeptide antibodies.

1988 • 59 citations

Analysis of stimulation-G protein subunit coupling by using active insulin-like growth factor II receptor peptide.

1991 • 49 citations

Measurement of GTPγS binding to specific G proteins in membranes using G-protein antibodies

1992 • 43 citations

Insulin-like growth factor-II/mannose 6-phosphate receptor is incapable of activating GTP-binding proteins in response to mannose 6-phosphate, but capable in response to insulin-like growth factor-II

1990 • 39 citations

Modes of inhibitory action of 4β-phorbol 12-myristate 13-acetate in thrombin-stimulated arachidonic acid release in intact and permeabilized platelets

1990 • 10 citations