Translational control in the endoplasmic reticulum stress response

Control of inositol 1,4,5-trisphosphate-induced Ca2+ release by cytosolic Ca2+

1995 • 5,025 citations

Protein folding in the cell

1992 • 4,138 citations

XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response to ER Stress to Produce a Highly Active Transcription Factor

2001 • 3,799 citations

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β

2000 • 3,241 citations

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

1999 • 3,119 citations

Regulated Translation Initiation Controls Stress-Induced Gene Expression in Mammalian Cells

2000 • 3,071 citations

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

2002 • 2,702 citations

Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response

2000 • 2,696 citations

Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases

2002 • 2,424 citations

Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls

1999 • 2,237 citations

CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

1998 • 1,972 citations

Perk Is Essential for Translational Regulation and Cell Survival during the Unfolded Protein Response

2000 • 1,933 citations

Gadd153 Sensitizes Cells to Endoplasmic Reticulum Stress by Down-Regulating Bcl2 and Perturbing the Cellular Redox State

2001 • 1,840 citations

Translational control of gene expression

2000 • 1,371 citations

Translational Control Is Required for the Unfolded Protein Response and In Vivo Glucose Homeostasis

2001 • 1,329 citations

Feedback Inhibition of the Unfolded Protein Response by GADD34-Mediated Dephosphorylation of eIF2α

2001 • 1,283 citations

Diabetes Mellitus and Exocrine Pancreatic Dysfunction in Perk−/− Mice Reveals a Role for Translational Control in Secretory Cell Survival

2001 • 1,204 citations

Orchestrating the unfolded protein response in health and disease

2002 • 1,163 citations

CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription.

1992 • 1,156 citations

Heat shock, stress proteins, chaperones, and proteotoxicity

1991 • 1,069 citations

Orchestrating the unfolded protein response in health and disease

2002 • 966 citations

Targeted disruption of the Chop gene delays endoplasmic reticulum stress–mediated diabetes

2002 • 858 citations

EIF2AK3, encoding translation initiation factor 2-α kinase 3, is mutated in patients with Wolcott-Rallison syndrome

2000 • 800 citations

Conformational disease

1997 • 794 citations

Identification and Characterization of Pancreatic Eukaryotic Initiation Factor 2 α-Subunit Kinase, PEK, Involved in Translational Control

1998 • 763 citations

Targeted disruption of the Chop gene delays endoplasmic reticulum stress–mediated diabetes

2002 • 724 citations

Gene-Specific Regulation by General Translation Factors

2002 • 720 citations

The unfolded protein response in nutrient sensing and differentiation

2002 • 592 citations

The PERK Eukaryotic Initiation Factor 2α Kinase Is Required for the Development of the Skeletal System, Postnatal Growth, and the Function and Viability of the Pancreas

2002 • 584 citations

A mutation in the insulin 2 gene induces diabetes with severe pancreatic β-cell dysfunction in the Mody mouse

1999 • 555 citations

Translational Regulation of Yeast GCN4

1997 • 533 citations

Mammalian stress response: induction of the glucose-regulated protein family

1992 • 452 citations

Ligand-independent Dimerization Activates the Stress Response Kinases IRE1 and PERK in the Lumen of the Endoplasmic Reticulum

2000 • 408 citations

Heme-regulated eIF2alpha kinase (HRI) is required for translational regulation and survival of erythroid precursors in iron deficiency

2001 • 373 citations

Immunoglobulin Binding Protein (BiP) Function Is Required to Protect Cells from Endoplasmic Reticulum Stress but Is Not Required for the Secretion of Selective Proteins

1997 • 346 citations

CHOP (GADD153) and its oncogenic variant, TLS-CHOP, have opposing effects on the induction of G1/S arrest.

1994 • 331 citations

Suppression of protein synthesis in brain during hibernation involves inhibition of protein initiation and elongation

1998 • 318 citations

Identification of novel stress-induced genes downstream of chop

1998 • 306 citations

Regulation of Translational Initiation during Cellular Responses to Stress

1997 • 280 citations

Integration of endoplasmic reticulum signaling in health and disease

1999 • 280 citations

5 Mechanism and Regulation of Initiator Methionyl-tRNA Binding to Ribosomes

2000 • 246 citations

Disturbances of the Functioning of Endoplasmic Reticulum: A Key Mechanism Underlying Neuronal Cell Injury?

1999 • 218 citations

Brain ischemia and reperfusion activates the eukaryotic initiation factor 2α kinase, PERK

2001 • 214 citations

Expression profiling of pancreatic β cells: Glucose regulation of secretory and metabolic pathway genes

2000 • 181 citations

GADD153/CHOP, a DNA damage-inducible protein, reduced CAAT/enhancer binding protein activities and increased apoptosis in 32D c13 myeloid cells.

1996 • 144 citations

Infancy-onset diabetes mellitus and multiple epiphyseal dysplasia

1972 • 141 citations

13 The Double-stranded RNA-activated Protein Kinase PKR

2000 • 106 citations

Increased cytotoxicity of chronic hypoxic cells by molecular inhibition of GRP78 induction

1994 • 80 citations

Suppression of protein synthesis in the reperfused brain.

1993 • 71 citations

Regulation of Antioxidant Metabolism by Translation Initiation Factor 2α

2001 • 65 citations

Translational Regulation in the Cellular Response to Biosynthetic Load on the Endoplasmic Reticulum

2001 • 49 citations

14 Heme-regulated eIF2α Kinase

2000 • 40 citations

Double the number of issues

1997 • 25 citations

Translational Regulation of the Immunoglobulin Heavy-Chain Binding Protein mRNA

1990 • 25 citations

The Perks of Balancing Glucose

2001 • 22 citations