Suppression of protein synthesis in brain during hibernation involves inhibition of protein initiation and elongation

Thresholds in cerebral ischemia - the ischemic penumbra.

1981 • 2,780 citations

Unifying theory of hypoxia tolerance: molecular/metabolic defense and rescue mechanisms for surviving oxygen lack.

1996 • 1,088 citations

Diphtheria Toxin

1977 • 780 citations

Phosphorylation of initiation factor 2α by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast

1992 • 768 citations

Metabolic Rate Depression and Biochemical Adaptation in Anaerobiosis, Hibernation and Estivation

1990 • 661 citations

Mechanism and regulation of eukaryotic protein synthesis

1992 • 591 citations

Regulation of protein synthesis in mammalian cells

1970 • 474 citations

Phosphorylation of elongation factor 2 by EF-2 kinase affects rate of translation

1988 • 447 citations

ADP-ribosylation of elongation factor 2 by diphtheria toxin. NMR spectra and proposed structures of ribosyl-diphthamide and its hydrolysis products.

1980 • 323 citations

Mechanism of action of Pseudomonas aeruginosa exotoxin Aiadenosine diphosphate-ribosylation of mammalian elongation factor 2 in vitro and in vivo

1977 • 266 citations

Phosphorylation of eukaryotic initiation factor 2 during physiological stresses which affect protein synthesis.

1987 • 257 citations

Local Cerebral Blood Flow during Hibernation, a Model of Natural Tolerance to “Cerebral Ischemia”

1994 • 234 citations

Inhibition of initiation of protein synthesis by 7-methylguanosine-5'-monophosphate.

1976 • 222 citations

Translation In Eukaryotes

1991 • 209 citations

Chapter 11 Disturbances of cerebral protein synthesis and ischemic cell death

1993 • 208 citations

Translational Regulation of Gene Expression 2

1993 • 202 citations

Mutations in Diphtheria Toxin Separate Binding from Entry and Amplify Immunotoxin Selectivity

1987 • 173 citations

Central role for differential gene expression in mammalian hibernation.

1992 • 163 citations

Protein synthesis elongation factor EF-1 alpha is essential for ubiquitin-dependent degradation of certain N alpha-acetylated proteins and may be substituted for by the bacterial elongation factor EF-Tu.

1994 • 161 citations

Hibernation in Ground Squirrels Induces State and Species-Specific Tolerance to Hypoxia and Aglycemia: AnIn VitroStudy in Hippocampal Slices

1998 • 145 citations

Metabolic adaptations supporting anoxia tolerance in reptiles: Recent advances

1996 • 142 citations

Global Brain Ischemia and Reperfusion: Modifications in Eukaryotic Initiation Factors Associated with Inhibition of Translation Initiation

1996 • 131 citations

Cellular ADP-ribosyltransferase with the same mechanism of action as diphtheria toxin and Pseudomonas toxin A.

1984 • 128 citations

A sodium dodecyl sulfate-polyacrylamide gel electrophoresis system that separates peptides and proteins in the molecular weight range of 2500 to 90,000

1983 • 124 citations

Relative importance of 7-methylguanosine in ribosome binding and translation of vesicular stomatitis virus mRNA in wheat germ and reticulocyte cell-free systems.

1977 • 121 citations

Effect of Brain Ischemia and Reperfusion on the Localization of Phosphorylated Eukaryotic Initiation Factor 2α

1997 • 120 citations

Measurement of local cerebral protein synthesis in vivo: influence of recycling of amino acids derived from protein degradation.

1988 • 110 citations

Membrane function in mammalian hibernation

1989 • 91 citations

Reduction of metabolic rate and thermoregulation during daily torpor

1995 • 84 citations

Molecular Mechanisms Responsible for Malignant Transformation by Regulatory and Catalytic Domain Variants of the Interferon-induced Enzyme RNA-dependent Protein Kinase

1995 • 79 citations

Saccharomyces cerevisiae elongation factor 2. Genetic cloning, characterization of expression, and G-domain modeling.

1992 • 74 citations

Primary structure at the site in beef and wheat elongation factor 2 of ADP‐ribosylation by diphtheria toxin

1979 • 73 citations

Regulation of polypeptide chain initiation in Chinese hamster ovary cells with a temperature-sensitive leucyl-tRNA synthetase. Changes in phosphorylation of initiation factor eIF-2 and in the activity of the guanine nucleotide exchange factor GEF.

1987 • 67 citations

alpha 2-Macroglobulin gene expression during hibernation in ground squirrels is independent of acute phase response

1995 • 65 citations

Acute blockage of the ubiquitin-mediated proteolytic pathway during invertebrate quiescence

1994 • 61 citations

Use of monoclonal antibodies to study the structure and function of eukaryotic protein synthesis initiation factor eIF‐2B

1994 • 60 citations

Disruption of cellular translational control by a viral truncated eukaryotic translation initiation factor 2α kinase homolog

1998 • 60 citations

Endogenous ADP-ribosylation of elongation factor 2 in polyoma virus-transformed baby hamster kidney cells.

1989 • 57 citations

Receptor-mediated transport of the hybrid protein ricin-diphtheria toxin fragment A with subsequent ADP-ribosylation of intracellular elongation factor II.

1979 • 46 citations

Occurrence of a differential expression of the glyceraldehyde-3-phosphate dehydrogenase gene in muscle and liver from euthermic and induced hibernating jerboa (Jaculus orientalis)

1996 • 44 citations

DISAGGREGATION OF BRAIN POLYSOMES AFTER ADMINISTRATION OF d‐LYSERGIC ACID DIETHYLAMIDE (LSD) IN VIVO

1976 • 42 citations

Rates of glucose utilization in brain of active and hibernating ground squirrels

1995 • 42 citations

Neuronal Damage after Repeated 5 Minutes of Ischemia in the Gerbil is Preceded by Prolonged Impairment of Protein Metabolism

1992 • 41 citations

The measurement of regional rates of cerebral protein synthesis in vivo

1991 • 27 citations

Preparation of a cell-free extract from rat brain which can initiate protein synthesis in vitro

1986 • 16 citations

Hibernators' brain: protein synthesis in the neocortex and the hippocampus

1985 • 16 citations

Phosphorylation of Elongation Factor 2

1993 • 11 citations

Peculiarities of functioning of protein-synthesizing apparatus of the hibernator (Citellus undulatus)

1992 • 10 citations