DNA-Binding Activity of Wild-Type p53 Protein is Mediated by the Central Part of the Molecule and Controlled by Its C Terminus

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

p53 Mutations in Human Cancers

1991 • 8,133 citations

Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes

1986 • 6,284 citations

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

Mutations in the p53 gene occur in diverse human tumour types

1989 • 2,765 citations

Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations

1994 • 2,460 citations

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1991 • 2,127 citations

Chromosome 17 Deletions and p53 Gene Mutations in Colorectal Carcinomas

1989 • 2,081 citations

The p53 proto-oncogene can act as a suppressor of transformation

1989 • 2,019 citations

Definition of a consensus binding site for p53

1992 • 2,000 citations

p53 function and dysfunction

1992 • 1,918 citations

Wild-type p53 is a cell cycle checkpoint determinant following irradiation.

1992 • 1,877 citations

Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53

1990 • 1,796 citations

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

1992 • 1,358 citations

Monoclonal antibodies specific for simian virus 40 tumor antigens

1981 • 1,110 citations

p53 mutations in colorectal cancer.

1990 • 1,030 citations

Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specific for the mutant form.

1990 • 978 citations

Regulation of the specific DNA binding function of p53

1992 • 914 citations

Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line.

1992 • 871 citations

Presence of a Potent Transcription Activating Sequence in the p53 Protein

1990 • 811 citations

Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53

1990 • 801 citations

p53 functions as a cell cycle control protein in osteosarcomas.

1990 • 774 citations

Wild-type p53 can inhibit oncogene-mediated focus formation.

1989 • 738 citations

A transcriptionally active DNA-binding site for human p53 protein complexes.

1992 • 729 citations

Transcriptional Activation by Wild-Type but Not Transforming Mutants of the p53 Anti-Oncogene

1990 • 644 citations

Cellular localization and cell cycle regulation by a temperature-sensitive p53 protein.

1991 • 544 citations

The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots.

1993 • 512 citations

Negative growth regulation in a glioblastoma tumor cell line that conditionally expresses human wild-type p53.

1990 • 502 citations

p53: At the Crossroads of Molecular Carcinogenesis and Risk Sssessment

1993 • 477 citations

Major deletions in the gene encoding the p53 tumor antigen cause lack of p53 expression in HL-60 cells.

1985 • 414 citations

Braking the cycle

1993 • 378 citations

Wild-type p53 mediates positive regulation of gene expression through a specific DNA sequence element.

1992 • 328 citations

High-Resolution Structure of the Oligomerization Domain of p53 by Multidimensional NMR

1994 • 300 citations

Monoclonal antibody analysis of p53 expression in normal and transformed cells

1986 • 285 citations

A proteolytic fragment from the central region of p53 has marked sequence-specific DNA-binding activity when generated from wild-type but not from oncogenic mutant p53 protein.

1993 • 263 citations

Growth suppression induced by wild-type p53 protein is accompanied by selective down-regulation of proliferating-cell nuclear antigen expression.

1991 • 251 citations

Localization of p53, retinoblastoma and host replication proteins at sites of viral replication in herpes-infected cells

1991 • 248 citations

Tumor suppressor p53: analysis of wild-type and mutant p53 complexes.

1991 • 242 citations

p53 domains: identification and characterization of two autonomous DNA-binding regions.

1993 • 239 citations

p53 transformation-related protein: Detection by monoclonal antibody in mouse and human cells

1981 • 222 citations

Wild-type p53 adopts a ‘mutant’-like conformation when bound to DNA.

1993 • 199 citations

Activation of the cryptic DNA binding function of mutant forms of p53

1993 • 190 citations

Subcellular distribution of the p53 protein during the cell cycle of Balb/c 3T3 cells.

1990 • 170 citations

Involvement of wild-type p53 in pre-B-cell differentiation in vitro.

1991 • 168 citations

Mutant p53 proteins bind DNA abnormally in vitro.

1991 • 166 citations

Rearrangements in the p53 gene in Philadelphia chromosome positive chronic myelogenous leukemia [see comments]

1989 • 157 citations

Induction of growth arrest by a temperature-sensitive p53 mutant is correlated with increased nuclear localization and decreased stability of the protein.

1991 • 142 citations

Expression of p53 protein in spermatogenesis is confined to the tetraploid pachytene primary spermatocytes.

1993 • 141 citations

Growth Suppression of Friend Virus-Transformed Erythroleukemia Cells by p53 Protein Is Accompanied by Hemoglobin Production and Is Sensitive to Erythropoietin

1993 • 140 citations

How loops, β sheets, and α helices help us to understand p53

1994 • 140 citations

Precise epitope mapping of the murine transformation-associated protein, p53.

1985 • 139 citations

Alterations in tumor development in vivo mediated by expression of wild type or mutant p53 proteins.

1991 • 131 citations

A potential transcriptional activation element in the p53 protein.

1990 • 129 citations

The dihedral symmetry of the p53 tetramerization domain mandates a conformational switch upon DNA binding.

1995 • 126 citations

Immunologically Distinct p53 Molecules Generated by Alternative Splicing

1986 • 120 citations

A DNA binding domain is contained in the C-terminus ofwild typep53 protein

1991 • 113 citations

The transforming and suppressor functions of p53 alleles: effects of mutations that disrupt phosphorylation, oligomerization and nuclear translocation.

1993 • 108 citations

Monoclonal antibodies against simian virus 40 nuclear large T tumour antigen: epitope mapping, papova virus cross-reaction and cell surface staining.

1984 • 107 citations

Expression of the normal p53 gene induces differentiation of K562 cells.

1992 • 83 citations

Isolation of a full-length mouse cDNA clone coding for an immunologically distinct p53 molecule.

1985 • 78 citations

Growth suppression of Friend virus-transformed erythroleukemia cells by p53 protein is accompanied by hemoglobin production and is sensitive to erythropoietin.

1993 • 77 citations

Wild type p53 functions as a control protein in the differentiation pathway of the B-cell lineage.

1993 • 75 citations

Cell cycle control of p53 in normal (3T3) and chemically transformed (Meth A) mouse cells. II. Requirement for cell cycle progression.

1990 • 74 citations

Human p53 binds DNA as a protein homodimer but monomeric variants retain full transcription transactivation activity.

1993 • 73 citations

Endogenous p53 protein generated from wild-type alternatively spliced p53 RNA in mouse epidermal cells.

1994 • 71 citations

Evidence for allosteric variants of wild-type p53, a tumour suppressor protein

1990 • 71 citations

Immunologically distinct p53 molecules generated by alternative splicing.

1986 • 64 citations

Does wild-type p53 play a role in normal cell differentiation?

1994 • 59 citations

Alternatively spliced p53 RNA in transformed and normal cells of different tissue types

1992 • 58 citations

A quick procedure for purification of functional recombinant proteins over-expressed inE.Coli

1991 • 58 citations

Cell cycle control by p53 in normal (3T3) and chemically transformed (Meth A) mouse cells. I. Regulation of p53 expression.

1990 • 46 citations

Isolation and characterization of DNA sequences that are specifically bound by wild-type p53 protein.

1993 • 37 citations

In search of the functions of normal p53 protein

1993 • 29 citations

The DNA binding activity of wild type p53 is modulated by blocking its various antigenic epitopes.

1995 • 18 citations

Expression of wild-type and mutant p53 proteins by recombinant vaccinia viruses

1992 • 15 citations