Phosphatase inhibitors suppress Ca2+ influx induced by receptor-mediated intracellular Ca2+ store depletion in human platelets

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Okadaic acid: a new probe for the study of cellular regulation

1990 • 1,396 citations

Calyculin A and okadaic acid: Inhibitors of protein phosphatase activity

1989 • 1,032 citations

Emptying of intracellular Ca2+ stores releases a novel small messenger that stimulates Ca2+ influx

1993 • 892 citations

Activation of Calcium Entry by the Tumor Promoter Thapsigargin in Parotid Acinar Cells

1989 • 887 citations

Thapsigargin, a novel molecular probe for studying intracellular calcium release and storage

1989 • 583 citations

Depletion of InsP3 stores activates a Ca2+ and K+ current by means of a phosphatase and a diffusible messenger

1993 • 363 citations

Uptake and intracellular sequestration of divalent cations in resting and methacholine-stimulated mouse lacrimal acinar cells. Dissociation by Sr2+ and Ba2+ of agonist-stimulated divalent cation entry from the refilling of the agonist-sensitive intracellular pool.

1990 • 298 citations

Role of a guanine nucleotide-binding regulatory protein in the hydrolysis of hepatocyte phosphatidylinositol 4,5-bisphosphate by calcium-mobilizing hormones and the control of cell calcium. Studies utilizing aluminum fluoride.

1985 • 290 citations

Receptor-mediated calcium entry in fura-2-loaded human platelets stimulated with ADP and thrombin. Dual-wavelengths studies with Mn2+

1989 • 248 citations

Coupling between intracellular Ca2+ stores and the Ca2+ permeability of the plasma membrane. Comparison of the effects of thapsigargin, 2,5-di-(tert-butyl)-1,4-hydroquinone, and cyclopiazonic acid in rat thymic lymphocytes.

1991 • 243 citations

The cytoplasmic concentration of free calcium in platelets is controlled by stimulators of cyclic AMP production (PGD2, PGE1, forskolin)

1983 • 217 citations

Tautomycin from the bacterium Streptomyces verticillatus

1990 • 191 citations

Ca2+ influx following receptor activation

1991 • 187 citations

Receptor-activated Ca2+ influx. Two independently regulated mechanisms of influx stimulation coexist in neurosecretory PC12 cells.

1992 • 166 citations

[40] Use of okadaic acid to inhibit protein phosphatases in intact cells

1991 • 162 citations

Receptor-activated Ca2+ influx. Two independently regulated mechanisms of influx stimulation coexist in neurosecretory PC12 cells.

1992 • 132 citations

Receptor‐mediated calcium entry

1990 • 127 citations

Evidence for the regulation of exocytic transport by protein phosphorylation.

1992 • 126 citations

Cytochrome P450 may regulate plasma membrane Ca ²⁺ permeability according to the filling state of the intracellular Ca ²⁺ stores

1992 • 116 citations

Separation of Two Phosphorylase Kinase Phosphatases from Rabbit Skeletal Muscle

1976 • 115 citations

Plasma membrane potential modulates chemotactic peptide-stimulated cytosolic free Ca2+ changes in human neutrophils.

1987 • 112 citations

Kinetic differences between thrombin-induced and ADP-induced calcium influx and release from internal stores in fura-2-loaded human platelets

1986 • 107 citations

Platelets and parotid acinar cells have different mechanisms for agonist-stimulated divalent cation entry.

1988 • 102 citations

Receptor-activated single channels in intact human platelets.

1990 • 96 citations

A novel protein phosphatase inhibitor, tautomycin Effect on smooth muscle

1991 • 71 citations

Two thrombin-activated Ca2+ channels in human platelets.

1992 • 55 citations

Control of plasma-membrane Ca2+ entry by the intracellular Ca2+ stores. Kinetic evidence for a short-lived mediator

1992 • 48 citations

Monitoring of the activation of receptor-operated calcium channels in human platelets

1989 • 44 citations

Inhibitory effect of 8-bromo cyclic GMP on an extracellular Ca2+-dependent arachidonic acid liberation in collagen-stimulated rabbit platelets

1989 • 38 citations

Cyclic nucleotides and intracellular‐calcium homeostasis in human platelets

1992 • 37 citations

Agonist-sensitive and -insensitive intracellular Ca2+ pools. Separate Ca2+-releasing mechanisms revealed by manoalide and benzohydroquinone

1991 • 36 citations

The inhibitory effects of okadaic acid on platelet function

1992 • 33 citations

Okadaic acid uncouples calcium entry from depletion of intracellular stores

1993 • 32 citations

Evaluation of platelet calcium ion mobilization by the use of various divalent ions

1992 • 30 citations

The possible involvement of protein phosphatase 1 in thrombin‐induced Ca²⁺ influx of human platelets

1993 • 17 citations

The effects of okadaic acid and calyculin A on thrombin induced platelet reaction.

1992 • 12 citations

Platelet protein phosphatases and their endogenous substrates.

1990 • 7 citations

Low concentrations of sodium fluoride inhibit Ca2+ influx induced by receptor-mediated platelet activation

1993 • 5 citations

Role of sodium ion gradient in facilitating extracellular calcium influx

1991 • 5 citations