Biogenesis of the Sorting Endosome: The Role of Rab5

SNAP receptors implicated in vesicle targeting and fusion

1993 • 3,220 citations

SNAREpins: Minimal Machinery for Membrane Fusion

1998 • 2,456 citations

Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 Å resolution

1998 • 2,377 citations

Mechanisms of intracellular protein transport

1994 • 2,280 citations

A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusion

1993 • 1,893 citations

Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin

1992 • 1,792 citations

ENDOCYTOSIS AND MOLECULAR SORTING

1996 • 1,537 citations

Signalling through the lipid products of phosphoinositide-3-OH kinase

1997 • 1,314 citations

EEA1 links PI(3)K function to Rab5 regulation of endosome fusion

1998 • 1,101 citations

rab5 controls early endosome fusion in vitro

1991 • 1,090 citations

Conserved structural features of the synaptic fusion complex: SNARE proteins reclassified as Q- and R-SNAREs

1998 • 1,032 citations

Inhibition of rab5 GTPase activity stimulates membrane fusion in endocytosis.

1994 • 948 citations

Phosphatidylinositol 3-Kinase Encoded by Yeast VPS 34 Gene Essential for Protein Sorting

1993 • 909 citations

The Rab5 effector EEA1 is a core component of endosome docking

1999 • 850 citations

Brefeldin A's effects on endosomes, lysosomes, and the TGN suggest a general mechanism for regulating organelle structure and membrane traffic

1991 • 832 citations

Structure and Conformational Changes in NSF and Its Membrane Receptor Complexes Visualized by Quick-Freeze/Deep-Etch Electron Microscopy

1997 • 788 citations

Three-dimensional structure of the neuronal-Sec1–syntaxin 1a complex

2000 • 783 citations

The diversity of Rab proteins in vesicle transport

1997 • 762 citations

A conformational switch in syntaxin during exocytosis: role of munc18

1999 • 742 citations

Membrane transport in the endocytic pathway

1995 • 644 citations

Phosphatidylinositol-3-OH kinases are Rab5 effectors

1999 • 625 citations

A Novel Rab5 GDP/GTP Exchange Factor Complexed to Rabaptin-5 Links Nucleotide Exchange to Effector Recruitment and Function

1997 • 586 citations

Multivesicular endosomes containing internalized EGF-EGF receptor complexes mature and then fuse directly with lysosomes.

1996 • 531 citations

Oligomeric Complexes Link Rab5 Effectors with NSF and Drive Membrane Fusion via Interactions between EEA1 and Syntaxin 13

1999 • 523 citations

Rab5 regulates motility of early endosomes on microtubules

1999 • 504 citations

Phosphatidylinositol(3)-Phosphate Signaling Mediated by Specific Binding to RING FYVE Domains

1998 • 497 citations

Rabaptin-5 is a direct effector of the small GTPase Rab5 in endocytic membrane fusion

1995 • 476 citations

Transport-vesicle targeting: tethers before SNAREs

1999 • 451 citations

Rab GTPases coordinate endocytosis

2000 • 447 citations

The Phagosome: Compartment with a License to Kill

2007 • 433 citations

Coiled Coils in Both Intracellular Vesicle and Viral Membrane Fusion

1998 • 412 citations

Ca2+/calmodulin signals the completion of docking and triggers a late step of vacuole fusion

1998 • 390 citations

GTPase activity of Rab5 acts as a timer for endocytic membrane fusion

1996 • 322 citations

SNARE Interactions Are Not Selective

1999 • 322 citations

Mixed and Non-cognate SNARE Complexes

1999 • 319 citations

Membrane association of Rab5 mediated by GDP-dissociation inhibitor and accompanied by GDP/GTP exchange

1994 • 313 citations

Syntaxin 13 Mediates Cycling of Plasma Membrane Proteins via Tubulovesicular Recycling Endosomes

1998 • 294 citations

Lysosome-endosome fusion and lysosome biogenesis

2000 • 292 citations

Mannose 6–Phosphate Receptors Are Sorted from Immature Secretory Granules via Adaptor Protein AP-1, Clathrin, and Syntaxin 6–positive Vesicles

1998 • 290 citations

Syntaxin 6 functions in trans-Golgi network vesicle trafficking.

1997 • 286 citations

Assembly and disassembly of a ternary complex of synaptobrevin, syntaxin, and SNAP-25 in the membrane of synaptic vesicles

1997 • 275 citations

A novel role for Rab5–GDI in ligand sequestration into clathrin-coated pits

1998 • 273 citations

Folding intermediates of SNARE complex assembly.

1999 • 272 citations

Mutant Rab7 Causes the Accumulation of Cathepsin D and Cation-independent Mannose 6–Phosphate Receptor in an Early Endocytic Compartment

1998 • 265 citations

Rapid and efficient fusion of phospholipid vesicles by the α-helical core of a SNARE complex in the absence of an N-terminal regulatory domain

1999 • 259 citations

The Rab5 Effector EEA1 Interacts Directly with Syntaxin-6

1999 • 247 citations

Role of Membrane Organization and Membrane Domains in Endocytic Lipid Trafficking

2000 • 245 citations

Phosphoinositide 3-Kinases and Their FYVE Domain-containing Effectors as Regulators of Vacuolar/Lysosomal Membrane Trafficking Pathways

1999 • 237 citations

Involvement of the endosomal autoantigen EEA1 in homotypic fusion of early endosomes

1998 • 223 citations

The FYVE Domain of Early Endosome Antigen 1 Is Required for Both Phosphatidylinositol 3-Phosphate and Rab5 Binding

2000 • 220 citations

Distinct Rab-binding domains mediate the interaction of Rabaptin-5 with GTP-bound rab4 and rab5

1998 • 218 citations

Fusion of Lysosomes with Late Endosomes Produces a Hybrid Organelle of Intermediate Density and Is NSF Dependent

1998 • 216 citations

The N-Ethylmaleimide-sensitive Fusion Protein and α-SNAP Induce a Conformational Change in Syntaxin

1995 • 210 citations

Vamp-7 Mediates Vesicular Transport from Endosomes to Lysosomes

1999 • 202 citations

FYVE-finger proteins – effectors of an inositol lipid

1999 • 199 citations

Vac1p coordinates Rab and phosphatidylinositol 3-kinase signaling in Vps45p-dependent vesicle docking/fusion at the endosome

1999 • 186 citations

Selective Membrane Recruitment of EEA1 Suggests a Role in Directional Transport of Clathrin-coated Vesicles to Early Endosomes

2000 • 178 citations

The Phosphatidylinositol 3-Phosphate Binding Protein Vac1p Interacts with a Rab GTPase and a Sec1p Homologue to Facilitate Vesicle-mediated Vacuolar Protein Sorting

1999 • 159 citations

Differential Roles of Syntaxin 7 and Syntaxin 8 in Endosomal Trafficking

1999 • 157 citations

A novel Sec18p/NSF-dependent complex required for Golgi-to-endosome transport in yeast.

1997 • 153 citations

The endosome fusion regulator early-endosomal autoantigen 1 (EEA1) is a dimer

1999 • 127 citations

VPS21Controls Entry of Endocytosed and Biosynthetic Proteins into the Yeast Prevacuolar Compartment

2000 • 106 citations

Microtubule-based membrane movement

1998 • 105 citations

Syntaxin 7 Mediates Endocytic Trafficking to Late Endosomes

2000 • 100 citations

A new beat for the SNARE drum

1998 • 95 citations

A role for microtubules in sorting endocytic vesicles in rat hepatocytes.

1992 • 88 citations

The endosome fusion regulator early-endosomal autoantigen 1 (EEA1) is a dimer

1999 • 83 citations

Promiscuity in Rab–SNARE Interactions

1999 • 58 citations

Formation and Turnover of NSF- and SNAP-containing “Fusion” Complexes Occur on Undocked, Clathrin-coated Vesicle–derived Membranes

1998 • 18 citations