Expression of functional c-kit receptors rescues the genetic defect of W mutant mast cells.

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Improved retroviral vectors for gene transfer and expression.

1989 • 1,997 citations

Stem cell factor is encoded at the SI locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor

1990 • 1,448 citations

The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus

1988 • 1,390 citations

The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene

1988 • 1,336 citations

The hematopoietic growth factor KL is encoded by the SI locus and is the ligand of the c-kit receptor, the gene product of the W locus

1990 • 1,208 citations

Hereditary Anemias of the Mouse: A Review for Geneticists

1979 • 1,141 citations

A safe packaging line for gene transfer: separating viral genes on two different plasmids

1988 • 1,118 citations

Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors

1988 • 1,086 citations

Identification of a ligand for the c-kit proto-oncogene

1990 • 970 citations

Molecular cloning of mast cell growth factor, a hematopoietin that is active in both membrane bound and soluble forms

1990 • 870 citations

Decrease of mast cells in W/Wv mice and their increase by bone marrow transplantation

1978 • 846 citations

Identification, purification, and biological characterization of hematopoietic stem cell factor from buffalo rat liver-conditioned medium

1990 • 837 citations

Primary structure and functional expression of rat and human stem cell factor DNAs

1990 • 779 citations

Transmembrane form of the kit ligand growth factor is determined by alternative splicing and is missing in the SId mutant

1991 • 740 citations

Mast cell growth factor maps near the steel locus on mouse chromosome 10 and is deleted in a number of steel alleles

1990 • 632 citations

Molecular bases of dominant negative and loss of function mutations at the murine c-kit/white spotting locus: W37, Wv, W41 and W.

1990 • 599 citations

Gene‐induced embryological modifications of primordial germ cells in the mouse

1957 • 556 citations

Fate of bone marrow-derived cultured mast cells after intracutaneous, intraperitoneal, and intravenous transfer into genetically mast cell-deficient W/Wv mice. Evidence that cultured mast cells can give rise to both connective tissue type and mucosal mast cells.

1985 • 503 citations

Expression of c-kit gene products in known cellular targets of W mutations in normal and W mutant mice--evidence for an impaired c-kit kinase in mutant mice.

1989 • 495 citations

Cloning and sequencing of a deoxyribonucleic acid copy of glyceraldehyde 3-phosphate dehydrogenase messenger ribonucleic acid isolated from chicken muscle

1983 • 486 citations

Gonadal expression of c-kit encoded at the W locus of the mouse

1990 • 479 citations

Genes with promoters in retrovirus vectors can be independently suppressed by an epigenetic mechanism

1984 • 440 citations

Developmental expression of c-kit, a proto-oncogene encoded by the W locus

1990 • 349 citations

W mutant mice with mild or severe developmental defects contain distinct point mutations in the kinase domain of the c-kit receptor.

1990 • 349 citations

Spleen-Colony Formation in Anemic Mice of Genotype WW ^V

1964 • 331 citations

Candidate ligand for the c-kit transmembrane kinase receptor: KL, a fibroblast derived growth factor stimulates mast cells and erythroid progenitors.

1990 • 304 citations

Steel-Dickie mutation encodes a c-kit ligand lacking transmembrane and cytoplasmic domains.

1991 • 300 citations

The Dominant W ⁴² Spotting Phenotype Results from a Missense Mutation in the c- kit Receptor Kinase

1990 • 287 citations

Three stages of erythropoietic progenitor cell differentiation distinguished by a number of physical and biologic properties

1978 • 269 citations

The Steel/W transduction pathway: kit autophosphorylation and its association with a unique subset of cytoplasmic signaling proteins is induced by the Steel factor.

1991 • 264 citations

Embryonic lethalities and endothelial tumors in chimeric mice expressing polyoma virus middle T oncogene

1988 • 255 citations

Signal Transduction Through the EGF Receptor Transfected in IL-3-Dependent Hematopoietic Cells

1988 • 238 citations

Expression of the c-kit proto-oncogene in the murine male germ cells.

1991 • 186 citations

Preferential expression of c-kit protooncogene transcripts in small cell lung cancer

1992 • 182 citations

Expression of the hst-1 and c-kit protooncogenes in human testicular germ cell tumors.

1991 • 180 citations

Production of human factor IX in animals by genetically modified skin fibroblasts: potential therapy for hemophilia B

1989 • 177 citations

Receptor tyrosine kinases: genetic evidence for their role in Drosophila and mouse development

1990 • 161 citations

The expression of the proto-oncogene C-kit in the blast cells of acute myeloblastic leukemia.

1989 • 157 citations

An experimental analysis of the pigment defect caused by mutations at the W and Sl loci in mice

1968 • 139 citations

Expression of human adenosine deaminase from various strong promoters after gene transfer into human hematopoietic cell lines

1989 • 114 citations

Expression of the M-CSF receptor is controlled posttranscriptionally by the dominant actions of GM-CSF or multi-CSF

1990 • 109 citations

Influence of murine mast cell growth factor (c-kit ligand) on colony formation by mouse marrow hematopoietic progenitor cells.

1991 • 106 citations

Induction of macrophage colony-stimulating factor-dependent growth and differentiation after introduction of the murine c-fms gene into FDC-P1 cells.

1989 • 88 citations

Fibroblast‐dependent growth of mouse mast cells in vitro: Duplication of mast cell depletion in mutant mice of w/w^v genotype

1988 • 81 citations

The c-fms gene complements the mitogenic defect in mast cells derived from mutant W mice but not mi (microphthalmia) mice.

1991 • 69 citations

Expression of the c-myc oncogene under control of an immunoglobulin enhancer in E mu-myc transgenic mice.

1987 • 69 citations

Expression of functional human EGF receptor on murine bone marrow cells.

1988 • 60 citations

Migration and proliferation of cultured neural crest cells in W mutant neural crest chimeras

1991 • 59 citations

Design of vectors for efficient expression of human purine nucleoside phosphorylase in skin fibroblasts from enzyme-deficient humans.

1988 • 54 citations

Modulation of c-kit mRNA and protein by hemopoietic growth factors.

1991 • 53 citations

The Steel/W Transduction Pathway: Kit Autophosphorylation and Its Association with a Unique Subset of Cytoplasmic Signaling Proteins Is Induced by the Steel Factor

1991 • 48 citations

Human colony-stimulating factor 1 (CSF-1) receptor confers CSF-1 responsiveness to interleukin-3-dependent 32DC13 mouse myeloid cells and abrogates differentiation in response to granulocyte CSF

1990 • 38 citations

Expression of functional c-kit receptors rescues the genetic defect of W mutant mast cells.

1991 • 36 citations

Receptor functions and ligand-dependent transforming potential of a chimeric kit proto-oncogene.

1990 • 33 citations

Expression of v-src induces a myeloproliferative disease in bone-marrow-reconstituted mice.

1989 • 25 citations

Expression of human CSF-1 receptor induces CSF-1-dependent proliferation in murine myeloid but not in T-lymphoid cells.

1991 • 17 citations

Induction of Macrophage Colony-Stimulating Factor-Dependent Growth and Differentiation after Introduction of the Murine c-fms Gene into FDC-P1 Cells

1989 • 16 citations

Expression of the c-myc Oncogene under Control of an Immunoglobulin Enhancer in Eµ-myc Transgenic Mice

1987 • 15 citations

Receptor Functions and Ligand-Dependent Transforming Potential of a Chimeric kit Proto-Oncogene

1990 • 12 citations

Modulation of c-kit mRNA and Protein by Hemopoietic Growth Factors

1991 • 8 citations