Highly efficient gene transfer in naive human T cells with a murine leukemia virus-based vector

HIV-1 entry into quiescent primary lymphocytes: Molecular analysis reveals a labile, latent viral structure

1990 • 1,560 citations

Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection.

1990 • 1,465 citations

T Lymphocyte-Directed Gene Therapy for ADA ⁻ SCID: Initial Trial Results After 4 Years

1995 • 1,464 citations

Integration of murine leukemia virus DNA depends on mitosis.

1993 • 931 citations

Turnover of naive- and memory-phenotype T cells.

1994 • 900 citations

Gene Therapy in Peripheral Blood Lymphocytes and Bone Marrow for ADA ⁻ Immunodeficient Patients

1995 • 846 citations

HIV-1 replication is controlled at the level of T cell activation and proviral integration.

1990 • 800 citations

Passage through mitosis is required for oncoretroviruses but not for the human immunodeficiency virus

1994 • 798 citations

Human T-cell receptor variable gene segment families

1995 • 663 citations

Lifespan of human lymphocyte subsets defined by CD45 isoforms

1992 • 642 citations

Engraftment of gene–modified umbilical cord blood cells in neonates with adenosine deaminase deficiency

1995 • 622 citations

Allogeneic sibling umbilical-cord-blood transplantation in children with malignant and non-malignant disease

1995 • 607 citations

Colocalization of retrovirus and target cells on specific fibronectin fragments increases genetic transduction of mammalian cells

1996 • 565 citations

T-cell repertoire diversity and clonal expansions in normal and clinical samples

1995 • 562 citations

Retrovirally marked CD34-enriched peripheral blood and bone marrow cells contribute to long-term engraftment after autologous transplantation

1995 • 496 citations

Preferential infection of CD4+ memory T cells by human immunodeficiency virus type 1: evidence for a role in the selective T-cell functional defects observed in infected individuals.

1990 • 443 citations

Isolation and properties of Moloney murine leukemia virus mutants: use of a rapid assay for release of virion reverse transcriptase

1981 • 439 citations

Optimized Codon Usage and Chromophore Mutations Provide Enhanced Sensitivity with the Green Fluorescent Protein

1996 • 435 citations

Cytokine Signals Are Sufficient for HIV-1 Infection of Resting Human T Lymphocytes

1999 • 428 citations

Stored placental blood for unrelated bone marrow reconstitution

1993 • 400 citations

An Enhanced Green Fluorescent Protein Allows Sensitive Detection of Gene Transfer in Mammalian Cells

1996 • 387 citations

Synthesis and Biological Activity of Novel Nonnucleoside Inhibitors of HIV-1 Reverse Transcriptase. 2-Aryl-Substituted Benzimidazoles

1997 • 370 citations

T lymphocytes with a normal ADA gene accumulate after transplantation of transduced autologous umbilical cord blood CD34+ cells in ADA-deficient SCID neonates

1998 • 334 citations

T-cell function in newborn mice and humans

1999 • 326 citations

Progression to the G₁b Phase of the Cell Cycle Is Required for Completion of Human Immunodeficiency Virus Type 1 Reverse Transcription in T Cells

1998 • 312 citations

Cellular and molecular mechanisms for reduced interleukin 4 and interferon-gamma production by neonatal T cells.

1991 • 261 citations

Peripheral blood lymphocytes as target cells of retroviral vector- mediated gene transfer

1994 • 246 citations

Lysis of ovarian cancer cells by human lymphocytes redirected with a chimeric gene composed of an antibody variable region and the Fc receptor gamma chain.

1993 • 242 citations

IL-7-Dependent Extrathymic Expansion of CD45RA+ T Cells Enables Preservation of a Naive Repertoire

1998 • 230 citations

Bone marrow extracellular matrix molecules improve gene transfer into human hematopoietic cells via retroviral vectors.

1994 • 228 citations

Intracellular Cytokine Profile of Cord and Adult Blood Lymphocytes

1998 • 223 citations

Optimization of Fibronectin-Assisted Retroviral Gene Transfer into Human CD34⁺Hematopoietic Cells

1997 • 215 citations

CD4+ T-cell memory, CD45R subsets and the persistence of antigen—a unifying concept

1998 • 212 citations

Preferential replication of HIV-1 in the CD45RO memory cell subset of primary CD4 lymphocytes in vitro.

1997 • 187 citations

Use of green fluorescent protein variants to monitor gene transfer and expression in mammalian cells

1996 • 171 citations

Undetectable CD40 ligand expression on T cells and low B cell responses to CD40 binding agonists in human newborns.

1995 • 159 citations

CD28 ligands CD80 (B7-1) and CD86 (B7-2) induce long-term autocrine growth of CD4⁺ T cells and induce similar patterns of cytokine secretion in vitro

1995 • 152 citations

A possible role for bcl-2 in regulating T-cell memory - a ‘balancing act’ between cell death and survival

1993 • 131 citations

Alloantigen priming induces a state of unresponsiveness in human umbilical cord blood T cells.

1995 • 125 citations

HIV does not replicate in naive CD4 T cells stimulated with CD3/CD28.

1997 • 125 citations

High-Efficiency Gene Transfer into Normal and Adenosine Deaminase-Deficient T Lymphocytes Is Mediated by Transduction on Recombinant Fibronectin Fragments

1998 • 124 citations

Ontogeny of expression of UCHL1 antigen on TcR‐1⁺ (CD4/8) and TcRδ⁺ T cells

1989 • 112 citations

Ineffective expression of CD40 ligand on cord blood T cells may contribute to poor immunoglobulin production in the newborn

1994 • 106 citations

Evidence for immunologic immaturity of cord blood T cells. Cord blood T cells are susceptible to tolerance induction to in vitro stimulation with a superantigen.

1995 • 90 citations

Retrovirus-Mediated Gene Transfer in Primary T Lymphocytes: Influence of the Transduction/Selection Process and ofex VivoExpansion on the T Cell Receptor β Chain Hypervariable Region Repertoire

2000 • 88 citations

Highly purified quiescent human peripheral blood CD4+ T cells are infectible by human immunodeficiency virus but do not release virus after activation

1995 • 87 citations

Memory T cell development in the absence of specific antigen priming.

1996 • 83 citations

High transdominant RevM10 protein levels are required to inhibit HIV-1 replication in cell lines and primary T cells: implication for gene therapy of AIDS

1997 • 78 citations

Production and Characterization of Functional Domains of Human Fibronectin Expressed in Escherichia coli

1991 • 73 citations

Naı̈ve and Memory CD4 T Cells Differ in Their Susceptibilities to Human Immunodeficiency Virus Type 1 Infection following CD28 Costimulation: Implications for Transmission and Pathogenesis

1998 • 73 citations

Green Fluorescent Protein as a Selectable Marker of Fibronectin-Facilitated Retroviral Gene Transfer in Primary Human T Lymphocytes

1999 • 71 citations

Interleukin 2 induces the expression of CD45RO and the memory phenotype by CD45RA+ peripheral blood lymphocytes.

1994 • 61 citations

Blocking of retroviral infection at a step prior to reverse transcription in cells transformed to constitutively express interferon beta.

1994 • 51 citations

Rapid identification of viable retrovirus-transduced cells using the green fluorescent protein as a marker

1997 • 50 citations

Aberrant CD3- and CD28-Mediated Signaling Events in Cord Blood T Cells Are Associated with Dysfunctional Regulation of Fas Ligand-Mediated Cytotoxicity

1999 • 50 citations

HIV infection of CD45RA+ and CD45RO+ CD4+ T cells

1997 • 46 citations

Restriction of the T-cell repertoire in tumor-infiltrating lymphocytes from nine patients with renal-cell carcinoma relevance of the CDR3 length analysis for the identification ofin situ clonal T-cell expansions

1996 • 46 citations

Preclinical Studies of Lymphocyte Gene Therapy for Mild Hunter Syndrome (Mucopolysaccharidosis Type II)

1996 • 41 citations

Expression of the interleukin-2 receptor gamma chain on cord blood mononuclear cells

1996 • 38 citations

Highly‐efficient gene transfer with retroviral vectors into human T lymphocytes on fibronectin

1998 • 37 citations

Cord blood as an alternative source for stem and progenitor cell transplantation

1995 • 34 citations

Protection of Primary Human T Cells from HIV Infection by Trev: A Transdominant Fusion Gene

1997 • 30 citations

Retrovirus-mediated transduction of primary ZAP-70-deficient human T cells results in the selective growth advantage of gene-corrected cells: implications for gene therapy

2000 • 25 citations

CD45 Isoform expression: Implications for recirculation of naive and memory cells

1991 • 14 citations