Retrovirus-Mediated Gene Transfer in Primary T Lymphocytes: Influence of the Transduction/Selection Process and ofex VivoExpansion on the T Cell Receptor β Chain Hypervariable Region Repertoire

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

HSV-TK Gene Transfer into Donor Lymphocytes for Control of Allogeneic Graft-Versus-Leukemia

1997 • 1,180 citations

T-cell depletion of HLA-identical transplants in leukemia

1991 • 771 citations

The sizes of the CDR3 hypervariable regions of the murine T-cell receptor beta chains vary as a function of the recombined germ-line segments.

1993 • 664 citations

Human T-cell receptor variable gene segment families

1995 • 663 citations

T-cell repertoire diversity and clonal expansions in normal and clinical samples

1995 • 562 citations

Following the fate of individual T cells throughout activation and clonal expansion. Signals from T cell receptor and CD28 differentially regulate the induction and duration of a proliferative response.

1997 • 489 citations

Perturbation of CD4+ and CD8+ T-cell repertoires during progression to AIDS and regulation of the CD4+ repertoire during antiviral therapy

1998 • 434 citations

Circulating T cell repertoire complexity in normal individuals and bone marrow recipients analyzed by CDR3 size spectratyping: correlation with immune status

1995 • 400 citations

Circulating T cell repertoire complexity in normal individuals and bone marrow recipients analyzed by CDR3 size spectratyping. Correlation with immune status.

1994 • 345 citations

An experimentally validated panel of subfamily‐specific oligonucleotide primers (V_α1‐w29/V_β1‐w24) for the study of human T cell receptor variable V gene segment usage by polymerase chain reaction

1992 • 302 citations

Oligoclonality of tumor-infiltrating lymphocytes from human melanomas.

1994 • 232 citations

Ganciclovir treatment of herpes simplex thymidine kinase-transduced primary T lymphocytes: an approach for specific in vivo donor T-cell depletion after bone marrow transplantation?

1994 • 220 citations

A Natural Immunological Adjuvant Enhances T Cell Clonal Expansion through a CD28-dependent, Interleukin (IL)-2–independent Mechanism

1998 • 220 citations

Structure and biological activity of human homologs of the raf/mil oncogene.

1985 • 203 citations

Public and private V beta T cell receptor repertoires against hen egg white lysozyme (HEL) in nontransgenic versus HEL transgenic mice.

1994 • 194 citations

The Umbilical Cord Blood αβ T-Cell Repertoire: Characteristics of a Polyclonal and Naive but Completely Formed Repertoire

1998 • 164 citations

Oligoclonal Expansions of CD8+ T Cells in Chronic HIV Infection Are Antigen Specific

1998 • 150 citations

T Cell Growth Cytokines Cause the Superinduction of Molecules Mediating Antigen-Induced T Lymphocyte Death

1998 • 141 citations

Infection efficiency of T lymphocytes with amphotropic retroviral vectors is cell cycle dependent

1989 • 129 citations

T-cell repertoires in healthy and diseased human tissues analysed by T-cell receptor β-chain CDR3 size determination: evidence for oligoclonal expansions in tumours and inflammatory diseases

1995 • 117 citations

Use of suicide genes in gene therapy

1994 • 87 citations

Use of Donor T-Lymphocytes Expressing Herpes-Simplex Thymidine Kinase in Allogeneic Bone Marrow Transplantation: A Phase I–II Study. Laboratorie d'Histocompatibilité et Thérapeutique Immuno-Moléculaire, Besançon, France

1997 • 83 citations

Distinctive properties of thymidine kinase isozymes induced by human and avian herpesviruses

1974 • 71 citations

IN VIVO ALLOREACTIVE POTENTIAL OF EX VIVO-EXPANDED PRIMARY T LYMPHOCYTES1

1998 • 64 citations

Ex Vivo Anti-CD3 Antibody-Activated Donor T Cells Have a Reduced Ability to Cause Lethal Murine Graft-Versus-Host Disease but Retain Their Ability to Facilitate Alloengraftment

1998 • 54 citations

Restriction of the T-cell repertoire in tumor-infiltrating lymphocytes from nine patients with renal-cell carcinoma relevance of the CDR3 length analysis for the identification ofin situ clonal T-cell expansions

1996 • 46 citations

A Closed Culture System for the Ex Vivo Transduction and Expansion of Human T Lymphocytes

1998 • 41 citations

Activation conditions determine susceptibility of murine primary T-lymphocytes to retroviral infection

1999 • 39 citations

Retrovirus-Mediated Transfer of the Herpes Simplex Type I Thymidine Kinase Gene in Alloreactive T Lymphocytes

1998 • 29 citations

“Suicide” gene for the control of graft-versus-host disease

1998 • 24 citations

Development of a Competitive PCR Method for In Vitro and In Vivo Quantification of Herpes Simplex Virus Thymidine Kinase and Neomycin Resistance-Expressing Cells Used in a Clinical Trial

2000 • 16 citations

Intrafamily fragment analysis of the T cell receptor β chain CDR3 region

1995 • 12 citations

Activation conditions determine susceptibility of murine primary T‐lymphocytes to retroviral infection

1999 • 5 citations