Integrins in Mammary Gland Development and Differentiation of Mammary Epithelium

Integrins

2002 • 8,127 citations

Epithelial–mesenchymal transitions in tumour progression

2002 • 6,431 citations

Cellular survival: a play in three Akts

1999 • 4,229 citations

Integrin Signaling

1999 • 3,705 citations

Reversion of the Malignant Phenotype of Human Breast Cells in Three-Dimensional Culture and In Vivo by Integrin Blocking Antibodies

1997 • 1,444 citations

Suppression of ICE and Apoptosis in Mammary Epithelial Cells by Extracellular Matrix

1995 • 1,184 citations

Stromal Effects on Mammary Gland Development and Breast Cancer

2002 • 902 citations

Sensing the environment: a historical perspective on integrin signal transduction

2002 • 855 citations

β4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium

2002 • 772 citations

Role of Cell Surface Metalloprotease Mt1-Mmp in Epithelial Cell Migration over Laminin-5

2000 • 650 citations

Reciprocal interactions between β1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: A different perspective in epithelial biology

1998 • 625 citations

Integrin activation controls metastasis in human breast cancer

2001 • 566 citations

Fibronectin requirement in branching morphogenesis

2003 • 537 citations

Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis

2003 • 531 citations

Integrins and cell proliferation

2001 • 509 citations

Normal and tumor-derived myoepithelial cells differ in their ability to interact with luminal breast epithelial cells for polarity and basement membrane deposition

2002 • 486 citations

Postnatal mammary gland development requires macrophages and eosinophils

2000 • 429 citations

Overexpression of AKT2/protein kinase Bbeta leads to up-regulation of beta1 integrins, increased invasion, and metastasis of human breast and ovarian cancer cells.

2003 • 416 citations

Laminin mediates tissue-specific gene expression in mammary epithelia.

1995 • 397 citations

Signaling Pathways in Mammary Gland Development

2001 • 396 citations

Integrin β1 Signaling Is Necessary for Transforming Growth Factor-β Activation of p38MAPK and Epithelial Plasticity

2001 • 381 citations

Positional Control of Cell Fate Through Joint Integrin/Receptor Protein Kinase Signaling

2003 • 374 citations

MT1-MMP Initiates Activation of pro-MMP-2 and Integrin αvβ3 Promotes Maturation of MMP-2 in Breast Carcinoma Cells

2001 • 373 citations

Activated integrin αvβ3 cooperates with metalloproteinase MMP-9 in regulating migration of metastatic breast cancer cells

2003 • 312 citations

Site-specific inductive and inhibitory activities of MMP-2 and MMP-3 orchestrate mammary gland branching morphogenesis

2003 • 293 citations

Integrin-Mediated Survival Signals Regulate the Apoptotic Function of Bax through Its Conformation and Subcellular Localization

2000 • 293 citations

The α2 Integrin Subunit-Deficient Mouse

2002 • 272 citations

Phenotypic Reversion or Death of Cancer Cells by Altering Signaling Pathways in Three-Dimensional Contexts

2002 • 268 citations

The α3β1 integrin is associated with mammary carcinoma cell metastasis, invasion, and gelatinase B (mmp-9) activity

2000 • 265 citations

Deletion of Integrin α1 by Homologous Recombination Permits Normal Murine Development but Gives Rise to a Specific Deficit in Cell Adhesion

1996 • 263 citations

Involvement of estrogen receptor β in terminal differentiation of mammary gland epithelium

2002 • 247 citations

Urokinase Receptors Promote β1 Integrin Function through Interactions with Integrin α3β1

2001 • 231 citations

Integrin αvβ3 expression confers on tumor cells a greater propensity to metastasize to bone

2002 • 220 citations

Processing of Integrin αv Subunit by Membrane Type 1 Matrix Metalloproteinase Stimulates Migration of Breast Carcinoma Cells on Vitronectin and Enhances Tyrosine Phosphorylation of Focal Adhesion Kinase

2002 • 212 citations

Extracellular Matrix Regulates Apoptosis in Mammary Epithelium through a Control on Insulin Signaling

1999 • 197 citations

High expression level of alpha 6 integrin in human breast carcinoma is correlated with reduced survival.

1995 • 194 citations

Control of Integrin Expression by Extracellular Matrix

1995 • 190 citations

Function of α3β1–Tetraspanin Protein Complexes in Tumor Cell Invasion. Evidence for the Role of the Complexes in Production of Matrix Metalloproteinase 2 (Mmp-2)

1999 • 182 citations

Branching morphogenesis of human mammary epithelial cells in collagen gels

1994 • 163 citations

Stat5 as a Target for Regulation by Extracellular Matrix

1995 • 154 citations

An Alternative Processing of Integrin αv Subunit in Tumor Cells by Membrane Type-1 Matrix Metalloproteinase

2002 • 152 citations

Protein Kinase A Regulates Rac and Is Required for the Growth Factor-stimulated Migration of Carcinoma Cells

2001 • 143 citations

Laminin and β1 Integrins Are Crucial for Normal Mammary Gland Development in the Mouse

1999 • 136 citations

Perturbation of beta 1-integrin function alters the development of murine mammary gland

1998 • 120 citations

Division of Labor among the α6β4 Integrin, β1 Integrins, and an E3 Laminin Receptor to Signal Morphogenesis and β-Casein Expression in Mammary Epithelial Cells

1999 • 118 citations

The spatial and temporal expression of the α2β1 integrin and its ligands, collagen I, collagen IV, and laminin, suggest important roles in mouse mammary morphogenesis

1995 • 111 citations

The role of laminin-5 and its receptors in mammary epithelial cell branching morphogenesis

1997 • 109 citations

Distinct ligand binding sites in integrin α3β1 regulate matrix adhesion and cell–cell contact

2003 • 107 citations

Regulation of Mammary Differentiation by Extracellular Matrix Involves Protein-tyrosine Phosphatases

1998 • 97 citations

α1 and α2 Integrins Mediate Invasive Activity of Mouse Mammary Carcinoma Cells through Regulation of Stromelysin-1 Expression

1999 • 94 citations

Collagen-IV and laminin-1 regulate estrogen receptor α expression and function in mouse mammary epithelial cells

2003 • 90 citations

The integrin alpha 6 beta 1 promotes the survival of metastatic human breast carcinoma cells in mice.

1997 • 90 citations

Cell–matrix interactions during development and apoptosis of the mouse mammary gland in vivo

2002 • 83 citations

Fibronectin and the α5β1 Integrin Are Under Developmental and Ovarian Steroid Regulation in the Normal Mouse Mammary Gland

2001 • 82 citations

Extracellular Matrix Selectively Modulates the Response of Mammary Epithelial Cells to Different Soluble Signaling Ligands

1999 • 81 citations

ECM-induced gap junctional communication enhances mammary epithelial cell differentiation

2003 • 79 citations

Myoepithelial cell diffeentiation in the developing mammary gland: Progressive acquisition of smooth muscle phenotype

1995 • 78 citations

Activation of NF‐κB p50/p65 is regulated in the developing mammary gland and inhibits STAT5‐mediated β‐casein gene expression

2000 • 76 citations

Activation of p53 Function in Carcinoma Cells by the α6β4 Integrin

1999 • 74 citations

Integrin laminin receptors and breast carcinoma progression.

2001 • 73 citations

Traction Forces Mediated by α6β4 Integrin: Implications for Basement Membrane Organization and Tumor Invasion

2001 • 73 citations

Migration of breast epithelial cells on Laminin-5: differential role of integrins in normal and transformed cell types

1998 • 73 citations

Epithelial Development and Differentiation in the Mammary Gland Is Not Dependent on α3 or α6 Integrin Subunits

2001 • 68 citations

Integrin α3β1 Engagement Disrupts Intercellular Adhesion

2001 • 67 citations

Growth defects induced by perturbation of β1‐integrin function in the mammary gland epithelium result from a lack of MAPK activation via the Shc and Akt pathways

2001 • 66 citations

Integrin function in breast carcinoma progression.

1999 • 57 citations

Early Events in the Anoikis Program Occur in the Absence of Caspase Activation

2003 • 55 citations

Tumour-stromal interactions Reciprocal regulation of extracellular matrix proteins and ovarian steroid activity in the mammary gland

2001 • 50 citations

EGF controls the in vivo developmental potential of a mammary epithelial cell line possessing progenitor properties

2002 • 50 citations

Control of Type II Transforming Growth Factor-β Receptor Expression by Integrin Ligation

1999 • 47 citations

Perturbation of β1-Integrin Function in Involuting Mammary Gland Results in Premature Dedifferentiation of Secretory Epithelial Cells

2002 • 41 citations

Cell-extracellular matrix interactions and EGF are important regulators of the basal mammary epithelial cell phenotype

1999 • 41 citations

Proliferation and differentiation in the human breast during pregnancy

2000 • 38 citations

Suppression of p53 function in normal human mammary epithelial cells increases sensitivity to extracellular matrix–induced apoptosis

2001 • 33 citations

Antibody-Induced Activation of β1 Integrin Receptors Stimulates cAMP-Dependent Migration of Breast Cells on Laminin-5

2000 • 15 citations

Modulation of α2β1 integrin changes during mammary gland development by β-oestradiol

2001 • 15 citations

Differential expression of integrin mRNAs and proteins during normal rat mammary gland development and in carcinogenesis

2001 • 13 citations

THE EXPRESSION PATTERNS OF INTEGRIN SUBUNITS ON HUMAN BREAST TISSUES OBTAINED DURING PREGNANCY

2002 • 5 citations