An Alternative Processing of Integrin αv Subunit in Tumor Cells by Membrane Type-1 Matrix Metalloproteinase

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

Matrix Metalloproteinases

1999 • 3,774 citations

Integrin Signaling

1999 • 3,705 citations

A matrix metalloproteinase expressed on the surface of invasive tumour cells

1994 • 2,561 citations

Mechanism Of Cell Surface Activation Of 72-kDa Type IV Collagenase

1995 • 1,576 citations

Localization of Matrix Metalloproteinase MMP-2 to the Surface of Invasive Cells by Interaction with Integrin αvβ3

1996 • 1,555 citations

Bidirectional signaling between the cytoskeleton and integrins

1999 • 765 citations

Cellular Mechanisms for Human Procollagenase-3 (MMP-13) Activation

1996 • 741 citations

Membrane-Type 1 Matrix Metalloproteinase Cleaves Cd44 and Promotes Cell Migration

2001 • 732 citations

Disruption of Angiogenesis by PEX, a Noncatalytic Metalloproteinase Fragment with Integrin Binding Activity

1998 • 618 citations

Regulation of Cell Invasion and Morphogenesis in a Three-Dimensional Type I Collagen Matrix by Membrane-Type Matrix Metalloproteinases 1, 2, and 3

2000 • 588 citations

Integrins and cancer

1996 • 520 citations

MT1-MMP Initiates Activation of pro-MMP-2 and Integrin αvβ3 Promotes Maturation of MMP-2 in Breast Carcinoma Cells

2001 • 373 citations

Fibronectin and integrins in invasion and metastasis

1995 • 315 citations

Integrin α2β1 Is a Positive Regulator of Collagenase (MMP-1) and Collagen α1(I) Gene Expression

1995 • 281 citations

The α3β1 integrin is associated with mammary carcinoma cell metastasis, invasion, and gelatinase B (mmp-9) activity

2000 • 265 citations

Matrix-dependent Proteolysis of Surface Transglutaminase by Membrane-type Metalloproteinase Regulates Cancer Cell Adhesion and Locomotion

2001 • 235 citations

cDNA and amino acid sequences of the cell adhesion protein receptor recognizing vitronectin reveal a transmembrane domain and homologies with other adhesion protein receptors.

1986 • 231 citations

Integrin activation: the link between ligand binding and signal transduction

1996 • 227 citations

The extracellular matrix ligands fibronectin and tenascin collaborate in regulating collagenase gene expression in fibroblasts.

1994 • 222 citations

Processing of Integrin αv Subunit by Membrane Type 1 Matrix Metalloproteinase Stimulates Migration of Breast Carcinoma Cells on Vitronectin and Enhances Tyrosine Phosphorylation of Focal Adhesion Kinase

2002 • 212 citations

Role of integrins in angiogenesis

1996 • 191 citations

Control of Integrin Expression by Extracellular Matrix

1995 • 190 citations

Mutation Analysis of Membrane Type-1 Matrix Metalloproteinase (MT1-MMP)

2001 • 158 citations

Multiple Roles of Integrins in Cell Motility

2000 • 158 citations

Functional activation of integrin ?v?3 in tumor cells expressing membrane-type 1 matrix metalloproteinase

2000 • 156 citations

Expression of integrin αvβ3 correlates with activation of membrane-type matrix metalloproteinase-1 (MT1-MMP) and matrix metalloproteinase-2 (MMP-2) in human melanoma cellsin vitro andin vivo

2000 • 136 citations

Intact Vitronectin Induces Matrix Metalloproteinase-2 and Tissue Inhibitor of Metalloproteinases-2 Expression and Enhanced Cellular Invasion by Melanoma Cells

1998 • 123 citations

Cell Migration in the Immune System: the Evolving Inter-Related Roles of Adhesion Molecules and Proteinases

2000 • 119 citations

Endoproteolytic processing of integrin pro-α subunits involves the redundant function of furin and proprotein convertase (PC) 5A, but not paired basic amino acid converting enzyme (PACE) 4, PC5B or PC7

2000 • 104 citations

A Second Mutant Allele of Furin in the Processing-incompetent Cell Line, LoVo

1995 • 101 citations

High-affinity self-reactive human antibodies by design and selection: targeting the integrin ligand binding site.

1993 • 90 citations

Marked antiangiogenic and antitumor efficacy of AG3340 in chemoresistant human non-small cell lung cancer tumors: single agent and combination chemotherapy studies.

1999 • 88 citations

The ?v?6 integrin induces gelatinase B secretion in colon cancer cells

1999 • 78 citations

Differential Induction of Gelatinase B (MMP-9) and Gelatinase A (MMP-2) in T Lymphocytes upon α4β1-Mediated Adhesion to VCAM-1 and the CS-1 Peptide of Fibronectin

2000 • 77 citations

Determination of Matrix Metalloproteinase Activity Using Biotinylated Gelatin

2000 • 76 citations

Cleavage of the α6A Subunit Is Essential for Activation of the α6Aβ1 Integrin by Phorbol 12-Myristate 13-Acetate

1996 • 61 citations

Lack of integrin α-chain endoproteolytic cleavage in furin-deficient human colon adenocarcinoma cells LoVo

1996 • 60 citations

Anti-α3 integrin antibody induces the activated form of matrix metalloprotease-2 (MMP-2) with concomitant stimulation of invasion through matrigel by human rhabdomyosarcoma cells

1997 • 59 citations

Building synthetic antibodies as adhesive ligands for integrins

1994 • 49 citations

Identification of Substrate Sequences for Membrane Type-1 Matrix Metalloproteinase Using Bacteriophage Peptide Display Library

1999 • 48 citations

Role of Endoproteolytic Processing in the Adhesive and Signaling Functions of αvβ5 Integrin

2000 • 44 citations

Cell Density Regulates Tyrosine Phosphorylation and Localization of Focal Adhesion Kinase

2001 • 16 citations