Regulating the onset of mitosis

Principles of CDK regulation

1995 • 3,267 citations

Cell Cycle Checkpoints: Preventing an Identity Crisis

1996 • 2,056 citations

Mitotic and G ₂ Checkpoint Control: Regulation of 14-3-3 Protein Binding by Phosphorylation of Cdc25C on Serine-216

1997 • 1,332 citations

Linkage of ATM to Cell Cycle Regulation by the Chk2 Protein Kinase

1998 • 1,314 citations

Conservation of the Chk1 Checkpoint Pathway in Mammals: Linkage of DNA Damage to Cdk Regulation Through Cdc25

1997 • 1,285 citations

Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport.

1991 • 858 citations

Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein

1999 • 580 citations

Purification and Molecular Cloning of Plx1, a Cdc25-Regulatory Kinase from Xenopus Egg Extracts

1996 • 506 citations

The Polo-like kinase Cdc5p and the WD-repeat protein Cdc20p/fizzy are regulators and substrates of the anaphase promoting complex in Saccharomyces cerevisiae

1998 • 488 citations

Human wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated cdc2 kinase

1993 • 456 citations

The roles of Drosophila cyclins A and B in mitotic control

1990 • 429 citations

Polo-like kinases: a team that plays throughout mitosis

1998 • 424 citations

S-phase-specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombe

1998 • 386 citations

The Human Myt1 Kinase Preferentially Phosphorylates Cdc2 on Threonine 14 and Localizes to the Endoplasmic Reticulum and Golgi Complex

1997 • 354 citations

Polo-like kinases: positive regulators of cell division from start to finish

1998 • 346 citations

14-3-3 Protein Homologs Required for the DNA Damage Checkpoint in Fission Yeast

1994 • 344 citations

MPF localization is controlled by nuclear export

1998 • 340 citations

Regulatory roles of cyclin dependent kinase phosphorylation in cell cycle control

1996 • 338 citations

Replication checkpoint requires phosphorylation of the phosphatase Cdc25 by Cds1 or Chk1

1998 • 338 citations

Nuclear export of cyclin B1 and its possible role in the DNA damage-induced G2 checkpoint

1998 • 331 citations

Replication Checkpoint Enforced by Kinases Cds1 and Chk1

1998 • 317 citations

Control of Cyclin B1 localization through regulated binding of the nuclear export factor CRM1

1998 • 316 citations

Nim1-related kinases coordinate cell cycle progression with the organization of the peripheral cytoskeleton in yeast

1999 • 308 citations

A Late Mitotic Regulatory Network Controlling Cyclin Destruction inSaccharomyces cerevisiae

1998 • 305 citations

A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase

1999 • 298 citations

Nuclear Localization of Cyclin B1 Controls Mitotic Entry After DNA Damage

1998 • 298 citations

Cyclin B2-null mice develop normally and are fertile whereas cyclin B1-null mice die in utero

1998 • 285 citations

Cdc2 Kinase Directly Phosphorylates the cis-Golgi Matrix Protein GM130 and Is Required for Golgi Fragmentation in Mitosis

1998 • 283 citations

Relocation and distinct subcellular localization of p34cdc2-cyclin B complex at meiosis reinitiation in starfish oocytes.

1992 • 271 citations

The differential localization of human cyclins A and B is due to a cytoplasmic retention signal in cyclin B.

1994 • 267 citations

Human cyclins B1 and B2 are localized to strikingly different structures: B1 to microtubules, B2 primarily to the Golgi apparatus.

1995 • 261 citations

Role of inhibitory CDC2 phosphorylation in radiation-induced G2 arrest in human cells.

1996 • 256 citations

Cell cycle analysis of the activity, subcellular localization, and subunit composition of human CAK (CDK-activating kinase).

1994 • 254 citations

The Polo-related kinase Cdc5 activates and is destroyed by the mitotic cyclin destruction machinery in S. cerevisiae

1998 • 244 citations

Cytoplasmic accumulation of cdc25B phosphatase in mitosis triggers centrosomal microtubule nucleation in HeLa cells

1996 • 234 citations

Activated Polo-Like Kinase Plx1 Is Required at Multiple Points during Mitosis in Xenopus laevis

1998 • 233 citations

Nuclear localization of cyclin B1 mediates its biological activity and is regulated by phosphorylation

1997 • 231 citations

Regulation of mitosis by cyclic accumulation of p80cdc25 mitotic inducer in fission yeast

1990 • 221 citations

Nuclear Import of Cdk/Cyclin Complexes: Identification of Distinct Mechanisms for Import of Cdk2/Cyclin E and Cdc2/Cyclin B1

1999 • 218 citations

Role of the Yeast Gin4p Protein Kinase in Septin Assembly and the Relationship between Septin Assembly and Septin Function

1998 • 217 citations

14-3-3 Proteins Act as Negative Regulators of the Mitotic Inducer Cdc25 inXenopusEgg Extracts

1998 • 214 citations

Distinct nuclear and spindle pole body populations of cyclin–cdc2 in fission yeast

1990 • 198 citations

The Polo-like kinase Plx1 is a component of the MPF amplification loop at the G2/M-phase transition of the cell cycle in Xenopus eggs

1998 • 190 citations

Drosophila Cyclin B3 is required for female fertility and is dispensable for mitosis like Cyclin B

1998 • 177 citations

Mitotic DNA damage and replication checkpoints in yeast

1998 • 172 citations

The Septins Are Required for the Mitosis-specific Activation of the Gin4 Kinase

1998 • 160 citations

A Morphogenesis Checkpoint Monitors the Actin Cytoskeleton in Yeast

1998 • 154 citations

Cdc28 tyrosine phosphorylation and the morphogenesis checkpoint in budding yeast.

1996 • 146 citations

The role of Cdk7 in CAK function, a retro-retrospective

1998 • 145 citations

Cdc34 and the F-box protein Met30 are required for degradation of the Cdk-inhibitory kinase Swe1

1998 • 140 citations

Control of Swe1p degradation by the morphogenesis checkpoint

1998 • 138 citations

Coupling of Mitosis to the Completion of S Phase Through Cdc34-Mediated Degradation of Wee1

1998 • 138 citations

The fission yeast SPB component Cut12 links bipolar spindle formation to mitotic control

1998 • 131 citations

Identification of a novel vertebrate cyclin: cyclin B3 shares properties with both A- and B-type cyclins.

1994 • 120 citations

Purification and Cloning of a Protein Kinase That Phosphorylates and Activates the Polo-Like Kinase Plx1

1998 • 119 citations

Nuclear RNA export

1998 • 114 citations

The Protein Kinase Cdr2, Related to Nim1/Cdr1 Mitotic Inducer, Regulates the Onset of Mitosis in Fission Yeast

1998 • 106 citations

A Role for NIMA in the Nuclear Localization of Cyclin B in Aspergillus nidulans

1998 • 103 citations

Thecdr2⁺Gene Encodes a Regulator of G₂/M Progression and Cytokinesis inSchizosaccharomyces pombe

1998 • 100 citations

The role of inhibitory phosphorylation of CDC2 following DNA replication block and radiation-induced damage in human cells.

1997 • 90 citations

Subcellular localisation of human wee1 kinase is regulated during the cell cycle

1995 • 79 citations

stf1: non-wee mutations epistatic to cdc25 in the fission yeast Schizosaccharomyces pombe.

1990 • 33 citations

Entry into mitosis without Cdc2 kinase activation

1998 • 25 citations

A phosphorylation site mutant of Schizosaccharomyces pombe cdc2p fails to promote the metaphase to anaphase transition

1998 • 6 citations