Monoclonal Antibody Therapy of B Cell Lymphoma: Signaling Activity on Tumor Cells Appears More Important Than Recruitment of Effectors

Phase I clinical trial using escalating single-dose infusion of chimeric anti-CD20 monoclonal antibody (IDEC-C2B8) in patients with recurrent B-cell lymphoma

1994 • 747 citations

Randomised trial of monoclonal antibody for adjuvant therapy of resected Dukes' C colorectal carcinoma

1994 • 647 citations

The CD19/CR2/TAPA-1 Complex of B Lymphocytes: Linking Natural to Acquired Immunity

1995 • 469 citations

Expansion or Elimination of B Cells In Vivo: Dual Roles for CD40- and Fas (CD95)-Ligands Modulated by the B Cell Antigen Receptor

1996 • 405 citations

Spontaneous murine B-cell leukaemia

1978 • 264 citations

Humanized CD52 monoclonal antibody campath‐1H as first‐line treatment in chronic lymphocytic leukaemia

1996 • 239 citations

Inhibition of human B-cell lymphoma growth by CD40 stimulation

1994 • 232 citations

Monoclonal antibody-based therapies of leukemia and lymphoma

1992 • 213 citations

Induction of DNA fragmentation in chronic B-lymphocytic leukemia cells.

1991 • 189 citations

Activation induces sensitivity toward APO-1 (CD95)-mediated apoptosis in human B cells.

1994 • 182 citations

Suppression of apoptosis in normal and neoplastic human B lymphocytes by CD40 ligand is independent of Bcl‐2 induction

1993 • 180 citations

IDEC-C2B8 (Rituximab) Anti-CD20 Monoclonal Antibody Therapy in Patients With Relapsed Low-Grade Non-Hodgkin's Lymphoma

1997 • 154 citations

Anti-idiotypic mechanisms involved in suppression of a mouse B cell lymphoma, BCL1.

1987 • 142 citations

Rescue from anti-IgM-induced programmed cell death by the B cell surface proteins CD20 and CD40

1992 • 142 citations

Self‐renewal of B‐1 lymphocytes is dependent on CD19

1996 • 132 citations

Importance of antibody isotype in monoclonal anti-idiotype therapy of a murine B cell lymphoma. A study of hybridoma class switch variants.

1986 • 129 citations

Antibodies as cytotoxic therapy.

1994 • 127 citations

Lymphoma regression induced by monoclonal anti-idiotypic antibodies correlates with their ability to induce Ig signal transduction and is not prevented by tumor expression of high levels of bcl-2 protein

1994 • 121 citations

IL-4 induces Fas resistance in B cells.

1996 • 115 citations

Homodimerization of tumor-reactive monoclonal antibodies markedly increases their ability to induce growth arrest or apoptosis of tumor cells

1997 • 112 citations

Influence of antibody isotype on passive serotherapy of lymphoma.

1985 • 112 citations

Properties of mouse CD40: Cellular distribution of CD40 and B cell activation by monoclonal anti‐mouse CD40 antibodies

1994 • 112 citations

Identification and characterization of the murine homologue of CD22, a B lymphocyte-restricted adhesion molecule.

1992 • 99 citations

Mechanism of binding of multivalent immune complexes to Fc receptors. 1. Equilibrium binding

1981 • 98 citations

Initial experience with treatment of human B cell lymphoma with anti-CD19 monoclonal antibody

1991 • 94 citations

Anti-CD19 inhibits the growth of human B-cell tumor lines in vitro and of Daudi cells in SCID mice by inducing cell cycle arrest

1994 • 90 citations

Engineered anti-CD38 monoclonal antibodies for immunotherapy of multiple myeloma.

1995 • 83 citations

Anti-Renal-Cell Carcinoma Chimeric Antibody G250 Facilitates Antibody-Dependent Cellular Cytotoxicity with In Vitro and In Vivo Interleukin-2-Activated Effectors

1996 • 74 citations

Lyn tyrosine kinase signals cell cycle arrest but not apoptosis in B-lineage lymphoma cells.

1994 • 73 citations

APO-1(CD95)-dependent and -independent antigen receptor-induced apoptosis in human T and B cell lines

1995 • 68 citations

Phase I clinical trial using escalating single-dose infusion of chimeric anti-CD20 monoclonal antibody (IDEC-C2B8) in patients with recurrent B-cell lymphoma

1994 • 60 citations

Initial experience in treating human lymphoma with a chimeric univalent derivative of monoclonal anti-idiotype antibody

1987 • 59 citations

Tumor Dormancy and Cell Signaling. V. Regrowth of the BCL1 Tumor After Dormancy Is Established

1997 • 56 citations

Tumor dormancy and cell signaling. II. Antibody as an agonist in inducing dormancy of a B cell lymphoma in SCID mice.

1995 • 55 citations

An in vitro line of the B cell tumor BCL1 can be activated by LPS to secrete IgM1.

1980 • 54 citations

Characterization of fragments of the murine Ia-associated invariant chain.

1991 • 49 citations

Analysis of the interaction of antibodies with immunoglobulin idiotypes on neoplastic B lymphocytes: implications for immunotherapy.

1987 • 47 citations

Emergence of immunoglobulin variants following treatment of a B cell leukemia with an immunotoxin composed of antiidiotypic antibody and saporin.

1987 • 44 citations

Trispecific F(ab')3 derivatives that use cooperative signaling via the TCR/CD3 complex and CD2 to activate and redirect resting cytotoxic T cells.

1991 • 44 citations

Differential In Vitro and In Vivo Antitumor Effects Mediated by Anti-CD40 and Anti-CD20 Monoclonal Antibodies Against Human B-Cell Lymphomas

1996 • 44 citations

Monoclonal Antibodies Raised Against the Idiotype of the Murine B Cell Lymphoma, BCL₁Act Primarily with Heavy Chain Determinants

1991 • 25 citations

Characterisation of a new murine B cell lymphoma

1986 • 17 citations

Differential response of malignant human B-cells to anti-IgM immunoglobulin (anti-mu) and B-cell growth factor: unique direct cytotoxicity of anti-mu on prolymphocytic leukemia cells

1990 • 15 citations

Monoclonal antibody-based therapies of leukemia and lymphoma

1992 • 14 citations

Activation and preferential expansion of rat cytotoxic (CD8) T cells in vitro and in vivo with a bispecific (anti-TCR alpha/beta x anti-CD2) F(ab')2 antibody.

1995 • 11 citations

Lymphoma regression induced by monoclonal anti-idiotypic antibodies correlates with their ability to induce Ig signal transduction and is not prevented by tumor expression of high levels of bcl-2 protein

1994 • 5 citations

Differential response of malignant human B-cells to anti-IgM immunoglobulin (anti-mu) and B-cell growth factor: unique direct cytotoxicity of anti-mu on prolymphocytic leukemia cells

1990 • 2 citations

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