What is the real role of CD40 in cancer immunotherapy?

T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions

1998 • 2,615 citations

A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell

1998 • 2,373 citations

Help for cytotoxic-T-cell responses is mediated by CD40 signalling

1998 • 2,106 citations

The CD40 Antigen and its Ligand

1994 • 1,259 citations

Biological and clinical aspects of interleukin 6

1990 • 1,091 citations

Tumor necrosis factors: developments during the last decade.

1996 • 473 citations

Fas ligation induces apoptosis of CD40-activated human B lymphocytes.

1995 • 402 citations

The role of CD40 in the regulation of humoral and cell-mediated immunity

1994 • 376 citations

Cross-linking CD40 on B cells rapidly activates nuclear factor-kappa B.

1994 • 358 citations

A central role of CD40 ligand in the regulation of CD4+ T-cell responses

1996 • 329 citations

CD40 ligation induces Apo-1/Fas expression on human B lymphocytes and facilitates apoptosis through the Apo-1/Fas pathway.

1995 • 285 citations

PROSPECTIVE STUDY OF CANCER IN PATIENTS WITH HYPOGAMMAGLOBULINAEMIA

1985 • 284 citations

The many roles of CD40 in cell-mediated inflammatory responses

1996 • 276 citations

Gene transfer of CD40-ligand induces autologous immune recognition of chronic lymphocytic leukemia B cells.

1998 • 247 citations

A New Mechanism of NK Cell Cytotoxicity Activation: The CD40–CD40 Ligand Interaction

1997 • 244 citations

Follicular lymphomas can be induced to present alloantigen efficiently: a conceptual model to improve their tumor immunogenicity.

1995 • 224 citations

Expression of CD28 and CD40 in human myeloma cells: a comparative study with normal plasma cells

1994 • 220 citations

Expression of functional CD40 antigen on Reed-Sternberg cells and Hodgkin's disease cell lines

1995 • 212 citations

Acquired CD40-ligand deficiency in chronic lymphocytic leukemia

1997 • 206 citations

Activation of the B-cell Surface Receptor CD40 Induces A20, a Novel Zinc Finger Protein That Inhibits Apoptosis

1995 • 205 citations

CD40 ligand triggered interleukin-6 secretion in multiple myeloma

1995 • 198 citations

Pre-B acute lymphoblastic leukemia cells may induce T-cell anergy to alloantigen

1996 • 173 citations

Interleukin 10 induces apoptotic cell death of B-chronic lymphocytic leukemia cells.

1994 • 162 citations

CD40 ligand is constitutively expressed in a subset of T cell lymphomas and on the microenvironmental reactive T cells of follicular lymphomas and Hodgkin's disease.

1995 • 156 citations

Pre-B acute lymphoblastic leukemia cells may induce T-cell anergy to alloantigen

1996 • 149 citations

Molecular Mechanisms Used by Tumors to Escape Immune Recognition

1993 • 120 citations

CD40 expression in malignant plasma cells. Role in stimulation of autocrine IL-6 secretion by a human myeloma cell line.

1994 • 112 citations

Role of the CD40 and CD95 (APO‐1/Fas) antigens in the apoptosis of human B‐cell malignancies

1997 • 111 citations

Autologous Tumor Infiltrating T Cells Cytotoxic for Follicular Lymphoma Cells Can Be Expanded In Vitro

1997 • 102 citations

CD40 signaling-mediated induction of Bcl-XL, Cdk4, and Cdk6. Implication of their cooperation in selective B cell growth.

1995 • 101 citations

Expression and function of CD40 on Hodgkin and Reed-Sternberg cells and the possible relevance for Hodgkin's disease

1994 • 96 citations

Elevated levels of biologically active soluble CD40 ligand in the serum of patients with chronic lymphocytic leukaemia

1998 • 94 citations

B lymphocytes from patients with chronic lymphoproliferative disorders are equipped with different costimulatory molecules.

1997 • 91 citations

Abnormal CD40-mediated activation pathway in B lymphocytes from patients with hyper-IgM syndrome and normal CD40 ligand expression.

1997 • 89 citations

Different CD40-mediated signaling events require distinct CD40 structural features.

1996 • 85 citations

Regulation of CD80/B7-1 and CD86/B7-2 molecule expression in human primary acute myeloid leukemia and their role in allogenic immune recognition

1998 • 83 citations

CD4+ T-cell induction of Fas-mediated apoptosis in Burkitt's lymphoma B cells

1996 • 82 citations

Tumor Necrosis Factor-α Facilitates Induction of CD80 (B7-1) and CD54 on Human B Cells by Activated T Cells: Complex Regulation by IL-4, IL-10, and CD40L

1995 • 79 citations

CD40 expression in Hodgkin's disease.

1994 • 70 citations

Repression of apoptosis in human B-lymphoma cells by CD40-ligand and Bcl-2: relationship to the cell-cycle and role of the retinoblastoma protein.

1996 • 68 citations

Engagement of CD40 antigen with soluble CD40 ligand up-regulates peptide transporter expression and restores endogenous processing function in Burkitt's lymphoma cells.

1997 • 64 citations

HIV-1 induction of CD40 on endothelial cells promotes the outgrowth of AIDS-associated B-cell lymphomas

1997 • 61 citations

CD11a-CD18 and CD102 interactions mediate human myeloma cell growth arrest induced by CD40 stimulation.

1996 • 55 citations

Analysis of expression and function of CD40 on normal and leukemic human B cell precursors.

1990 • 53 citations

Anti-CD40 antibody binding modulates human multiple myeloma clonogenicity in vitro

1994 • 47 citations

CD40/CD40 Ligand Interactions in Normal, Reactive and Malignant Lympho-Hematopoietic Tissues

1997 • 46 citations

CD40 and CD95 induce programmed cell death in the human myeloma cell line XG2

1997 • 45 citations

Differential In Vitro and In Vivo Antitumor Effects Mediated by Anti-CD40 and Anti-CD20 Monoclonal Antibodies Against Human B-Cell Lymphomas

1996 • 44 citations

Identification of distinct domains in CD40 involved in B7-1 induction or growth inhibition.

1996 • 42 citations

Proliferation of B cell malignancies in all stages of differentiation upon stimulation in the 'CD40 system'.

1996 • 41 citations

Functional expression of adhesion receptors and costimulatory molecules by fresh and immortalized B-cell non-Hodgkin's lymphoma cells

1995 • 31 citations

Tumour immunology: false hopes—new horizons?

1998 • 31 citations

In Vivo Efficacy and Toxicity of a Single-Chain Immunotoxin Targeted to CD40

1997 • 25 citations

Immunodeficiency due to a faulty interaction between T cells and B cells

1994 • 16 citations

Epstein-Barr Virus-Induced Human B-Cell Lymphoma Arising in HuPBL-SCID Chimeric Mice: Characterization and the Role of CD40 Stimulation in Their Treatment and Prevention

1995 • 13 citations

Interleukin-8 antitumour effect is associated with a local infiltration but not with a systemic activation of T lymphocytes.

1994 • 12 citations

Effects of CD40 Stimulation in the Prevention of Human EBV-Lymphomagenesis

1997 • 12 citations

New insights into peripheral T-cell lymphomas

1995 • 9 citations

CD20 and CD40 mediated mitogenic responses in B‐lineage acute lymphoblastic leukaemia

1996 • 7 citations

Synergy between anti-CD40 MAb and Epstein-Barr virus in activation and transformation of human B lymphocytes

1997 • 2 citations