SH2- and SH3-mediated Interactions between Focal Adhesion Kinase and Src

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

1988 • 6,107 citations

SH2 domains recognize specific phosphopeptide sequences

1993 • 2,685 citations

Integrins: Emerging Paradigms of Signal Transduction

1995 • 1,591 citations

Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase

1994 • 1,590 citations

pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions.

1992 • 1,456 citations

Three-dimensional structure of the tyrosine kinase c-Src

1997 • 1,402 citations

Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly.

1992 • 1,330 citations

Autophosphorylation of the Focal Adhesion Kinase, ppl25^FAK, Directs SH2-Dependent Binding of pp60^src

1994 • 1,168 citations

Crystal structure of the Src family tyrosine kinase Hck

1997 • 1,165 citations

Control of adhesion-dependent cell survival by focal adhesion kinase.

1996 • 1,113 citations

Structural basis for the binding of proline-rich peptides to SH3 domains

1994 • 1,016 citations

Tyrosine Phosphorylation of Focal Adhesion Kinase at Sites in the Catalytic Domain Regulates Kinase Activity: a Role for Src Family Kinases

1995 • 989 citations

Modular binding domains in signal transduction proteins

1995 • 962 citations

Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src.

1994 • 844 citations

Regulation of focal adhesion-associated protein tyrosine kinase by both cellular adhesion and oncogenic transformation

1992 • 831 citations

Two Binding Orientations for Peptides to the Src SH3 Domain: Development of a General Model for SH3-Ligand Interactions

1994 • 800 citations

Cell adhesion or integrin clustering increases phosphorylation of a focal adhesion-associated tyrosine kinase.

1992 • 743 citations

Integrin-dependent phosphorylation and activation of the protein tyrosine kinase pp125FAK in platelets.

1992 • 669 citations

Adaptor plasmids simplify the insertion of foreign DNA into helper-independent retroviral vectors

1987 • 651 citations

Activation of the Sire-family tyrosine kinase Hck by SH3 domain displacement

1997 • 601 citations

Stimulation of cell migration by overexpression of focal adhesion kinase and its association with Src and Fyn

1996 • 595 citations

The when and how of Src regulation

1993 • 543 citations

pp125^FAK-Dependent Tyrosine Phosphorylation of Paxillin Creates a High-Affinity Binding Site for Crk

1995 • 534 citations

A mechanism for regulation of the adhesion-associated protein tyrosine kinase pp125FAK

1996 • 488 citations

Monoclonal antibodies to individual tyrosine-phosphorylated protein substrates of oncogene-encoded tyrosine kinases.

1990 • 480 citations

Fibronectin-Stimulated Signaling from a Focal Adhesion Kinase–c-Src Complex: Involvement of the Grb2, p130^cas, and Nck Adaptor Proteins

1997 • 432 citations

Identification of two juxtamembrane autophosphorylation sites in the PDGF beta-receptor; involvement in the interaction with Src family tyrosine kinases.

1993 • 354 citations

Transformation-specific tyrosine phosphorylation of a novel cellular protein in chicken cells expressing oncogenic variants of the avian cellular src gene.

1989 • 349 citations

Distinct ligand preferences of Src homology 3 domains from Src, Yes, Abl, Cortactin, p53bp2, PLCgamma, Crk, and Grb2.

1996 • 343 citations

Paxillin, a tyrosine phosphorylated focal adhesion-associated protein binds to the carboxyl terminal domain of focal adhesion kinase.

1995 • 341 citations

Direct interaction of v-Src with the focal adhesion kinase mediated by the Src SH2 domain.

1994 • 331 citations

High-resolution crystal structures of tyrosine kinase SH3 domains complexed with proline-rich peptides

1994 • 310 citations

Csk inhibition of c-Src activity requires both the SH2 and SH3 domains of Src.

1993 • 272 citations

A single amino acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV-1 Nef protein.

1995 • 256 citations

Measurement of the binding of tyrosyl phosphopeptides to SH2 domains: a reappraisal.

1995 • 253 citations

Platelet-derived growth factor induces multisite phosphorylation of pp60c-src and increases its protein-tyrosine kinase activity.

1988 • 250 citations

Coordinate activation of c-Src by SH3- and SH2-binding sites on a novel p130Cas-related protein, Sin.

1996 • 235 citations

Direct Binding of C-terminal Region of p130 to SH2 and SH3 Domains of Src Kinase

1996 • 229 citations

Regulation of c-Src tyrosine kinase activity by the Src SH2 domain.

1993 • 208 citations

The product of the protooncogene c-src is modified during the cellular response to platelet-derived growth factor.

1985 • 207 citations

SH2 domain specificity and activity modified by a single residue

1994 • 188 citations

Sequence Requirements for Binding of Src Family Tyrosine Kinases to Activated Growth Factor Receptors

1995 • 186 citations

Identification of Tyr-397 as the Primary Site of Tyrosine Phosphorylation and pp60^src Association in the Focal Adhesion Kinase, pp125^FAK

1995 • 185 citations

Monoclonal antibodies to Rous sarcoma virus pp60src react with enzymatically active cellular pp60src of avian and mammalian origin

1984 • 163 citations

Differential regulation of T cell antigen responsiveness by isoforms of the src-related tyrosine protein kinase p59fyn.

1992 • 151 citations

Suppression of c-Src activity by C-terminal Src kinase involves the c-Src SH2 and SH3 domains: analysis with Saccharomyces cerevisiae.

1993 • 132 citations

Rational Design of Specific High-Affinity Peptide Ligands for the Abl-SH3 Domain

1996 • 129 citations

Kinetics of p56lck and p60src Src homology 2 domain binding to tyrosine-phosphorylated peptides determined by a competition assay or surface plasmon resonance.

1993 • 117 citations

Affinity and specificity requirements for the first Src homology 3 domain of the Crk proteins.

1995 • 100 citations

Correlation of the Phosphorylation States of pp60^c-src with Tyrosine Kinase Activity: The Intramolecular pY530−SH2 Complex Retains Significant Activity If Y419 Is Phosphorylated

1996 • 96 citations

Regulation of the Lck SH2 Domain by Tyrosine Phosphorylation

1996 • 86 citations

Deletion of the SH3 domain of Src interferes with regulation by the phosphorylated carboxyl-terminal tyrosine.

1993 • 85 citations

Immunoaffinity purification of tyrosine-phosphorylated cellular proteins

1989 • 84 citations

Solution Structure of the Human pp60c-src SH2 Domain Complexed with a Phosphorylated Tyrosine Pentapeptide

1995 • 79 citations

The Grb2-mSos1 Complex Binds Phosphopeptides with Higher Affinity than Grb2

1996 • 75 citations

Interaction between the Amino-terminal SH3 Domain of CRK and Its Natural Target Proteins

1996 • 70 citations

Physical and functional interactions between SH2 and SH3 domains of the Src family protein tyrosine kinase p59fyn.

1994 • 64 citations

Thermodynamic Studies of Tyrosyl-Phosphopeptide Binding to the SH2 Domain of p56lck

1994 • 53 citations

Stability and peptide binding affinity of an SH3 domain from the Caenorhabditis elegans signaling protein Sem‐5

1994 • 53 citations

Quantitative analysis of Grb2-Sos1 interaction: the N-terminal SH3 domain of Grb2 mediates affinity.

1995 • 51 citations

Determination of Affinities for lck SH2 Binding Peptides Using a Sensitive Fluorescence Assay: Comparison between the pYEEIP and pYQPQP Consensus Sequences Reveals Context-Dependent Binding Specificity

1996 • 26 citations

Exploration of the Sequence Specificity of pp60c- Tyrosine Kinase

1995 • 21 citations

Catalytic Activity of the SH2 Domain of Human pp60c-src; Evidence from NMR, Mass Spectrometry, Site-Directed Mutagenesis and Kinetic Studies for an Inherent Phosphatase Activity

1995 • 10 citations