The Grb2-mSos1 Complex Binds Phosphopeptides with Higher Affinity than Grb2

SH2 domains recognize specific phosphopeptide sequences

1993 • 2,685 citations

Backbone Dynamics of a Free and a Phosphopeptide-Complexed Src Homology 2 Domain Studied by 15N NMR Relaxation

1994 • 2,051 citations

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

1993 • 1,236 citations

Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor

1993 • 1,077 citations

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

1993 • 1,026 citations

Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

1992 • 998 citations

Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

1993 • 972 citations

The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling.

1993 • 705 citations

Determination of Rate and Equilibrium Binding Constants for Macromolecular Interactions Using Surface Plasmon Resonance: Use of Nonlinear Least Squares Analysis Methods

1993 • 540 citations

Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor.

1994 • 450 citations

Crystal Structure of the Conserved Core of HIV-1 Nef Complexed with a Src Family SH3 Domain

1996 • 433 citations

Function of Ras as a molecular switch in signal transduction.

1992 • 425 citations

Measurement of protein concentration with interferences optics

1969 • 398 citations

The solution structure of HIV-1 Nef reveals an unexpected fold and permits delineation of the binding surface for the SH3 domain of Hck tyrosine protein kinase

1996 • 336 citations

Identification of murine homologues of the Drosophila son of sevenless gene: potential activators of ras.

1992 • 286 citations

A single amino acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV-1 Nef protein.

1995 • 256 citations

Activators and effectors of ras p21 proteins

1994 • 228 citations

Crystal Structure of the Mammalian Grb2 Adaptor

1995 • 202 citations

SH2 domains exhibit high-affinity binding to tyrosine-phosphorylated peptides yet also exhibit rapid dissociation and exchange.

1993 • 177 citations

A conserved amino-terminal Shc domain binds to phosphotyrosine motifs in activated receptors and phosphopeptides

1995 • 174 citations

Involvement of She in Insulin- and Epidermal Growth Factor-Induced Activation of p21^ras

1994 • 174 citations

Interaction of Shc with Grb2 Regulates Association of Grb2 with mSOS

1995 • 174 citations

Hemoglobin tertiary structural change on ligand binding its role in the co-operative mechanism

1983 • 173 citations

Binding of the Grb2 SH2 domain to phosphotyrosine motifs does not change the affinity of its SH3 domains for Sos proline-rich motifs.

1994 • 126 citations

The signaling pathway coupling epidermal growth factor receptors to activation of p21ras.

1994 • 121 citations

Downregulation of the Ras activation pathway by MAP kinase phosphorylation of Sos.

1995 • 106 citations

Regulation of Epidermal Growth Factor Receptor Signaling by Phosphorylation of the Ras Exchange Factor hSOS1

1996 • 106 citations

NMR structure of the N-terminal SH3 domain of GRB2 and its complex with a proline-rich peptide from Sos

1994 • 104 citations

Structure of the N-terminal SH3 domain of GRB2 complexed with a peptide from the guanine nucleotide releasing factor Sos

1994 • 97 citations

Phosphorylation of the Ras nucleotide exchange factor son of sevenless by mitogen-activated protein kinase.

1994 • 89 citations

MAP kinase phosphorylation of mSos1 promotes dissociation of mSos1-Shc and mSos1-EGF receptor complexes.

1995 • 85 citations

Orientation of Peptide Fragments from Sos Proteins Bound to the N-Terminal SH3 Domain of Grb2 Determined by NMR Spectroscopy

1994 • 80 citations

Role of Shc in the activation of Ras in response to epidermal growth factor and nerve growth factor.

1994 • 80 citations

In Vivo Functional Analysis of the Ras Exchange Factor Son of Sevenless

1995 • 76 citations

Independent binding of peptide ligands to the SH2 and SH3 domains of Grb2.

1994 • 75 citations

Insulin and Epidermal Growth Factor Receptors Regulate Distinct Pools of Grb2-SOS in the Control of Ras Activation

1996 • 68 citations

Functional Roles for the Pleckstrin and Dbl Homology Regions in the Ras Exchange Factor Son-of-sevenless

1995 • 65 citations

The Grb2 binding domain of mSos1 is not required for downstream signal transduction

1995 • 58 citations